0223/1G | Tocris Bioscience 0223/1G product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0223/1G

catalog :

0223/1G

quantity :

1 g

price :

113 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Styr B, Gonen N, Zarhin D, Ruggiero A, Atsmon R, Gazit N, et al. Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron. 2019;102:1009-1024.e8 pubmed publisher
Rojewska E, Ciapała K, Mika J. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model. Pharmacol Rep. 2019;71:139-148 pubmed publisher
Patel B, Bright D, Mortensen M, FrÃ¸lund B, Smart T. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci. 2016;36:607-21 pubmed publisher
Carver C, Wu X, Gangisetty O, Reddy D. Perimenstrual-like hormonal regulation of extrasynaptic Î´-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity. J Neurosci. 2014;34:14181-97 pubmed publisher
Weston M, Chen H, Swann J. Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. Front Mol Neurosci. 2014;7:1 pubmed publisher
Wu X, Gangisetty O, Carver C, Reddy D. Estrous cycle regulation of extrasynaptic ?-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis. J Pharmacol Exp Ther. 2013;346:146-60 pubmed publisher
Chen Z, Cooper B, Kalla S, Varoqueaux F, Young S. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci. 2013;33:8336-51 pubmed publisher
Thanawala M, Regehr W. Presynaptic calcium influx controls neurotransmitter release in part by regulating the effective size of the readily releasable pool. J Neurosci. 2013;33:4625-33 pubmed publisher
Gouet C, Aburto B, Vergara C, Sanhueza M. On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII. PLoS ONE. 2012;7:e49293 pubmed publisher
Weston M, Chen H, Swann J. Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. J Neurosci. 2012;32:11441-52 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Zhu P, Huang W, Kalikulov D, Yoo J, Placzek A, Stoica L, et al. Suppression of PKR promotes network excitability and enhanced cognition by interferon-?-mediated disinhibition. Cell. 2011;147:1384-96 pubmed publisher
Jones D, Howard M, Stanco A, Rubenstein J, Baraban S. Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. J Neurophysiol. 2011;105:1984-91 pubmed publisher
Shinoda Y, Sadakata T, Nakao K, Katoh Semba R, Kinameri E, Furuya A, et al. Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. Proc Natl Acad Sci U S A. 2011;108:373-8 pubmed publisher
Young S, Neher E. Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron. 2009;63:482-96 pubmed publisher
Mancilla J, Manis P. Two distinct types of inhibition mediated by cartwheel cells in the dorsal cochlear nucleus. J Neurophysiol. 2009;102:1287-95 pubmed publisher
Pérez León J, Warren E, Allen C, Robinson D, Brown R. Synaptic inputs to retinal ganglion cells that set the circadian clock. Eur J Neurosci. 2006;24:1117-23 pubmed
Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006;281:22021-8 pubmed

product information

master code :

223

SKU :

0223/1G

product name :

Kynurenic acid

unit size :

1 g

description :

Broad spectrum glutamatergic antagonist

target :

iGluR Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

189.17

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Kynurenic acid is a broad spectrum EAA antagonist. Putative GPR35 ligand. Kynurenic acid protects tissues in cardiac, cerebral, renal, and retinal ischemia models via activation of GPR35 and induction of ATP synthase dimerization in an ATPIF1-dependent and pertussis toxin (Cat. No. 3097) sensitive manner. . Sodium Salt also available.

top caption :

Broad spectrum glutamatergic antagonist

extended description :

Broad spectrum glutamatergic antagonist

chemical name text :

4-Hydroxyquinoline-2-carboxylic acid

formula :

C10H7NO3

formula text :

C10H7NO3

cas num :

492-27-3

USD :

113 USD

product details :

Broad spectrum glutamatergic antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage