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product summary
company name :
Tocris Bioscience
product type :
chemical
product name :
Kainic acid
catalog :
0222/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
96 USD
citations: 35
Reference
Limon A, Delbruck E, Yassine A, Pandya D, Myers R, Barchas J, et al. Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors. Transl Psychiatry. 2019;9:218 pubmed publisher
Spitzer S, Sitnikov S, Kamen Y, Evans K, Kronenberg Versteeg D, Dietmann S, et al. Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age. Neuron. 2019;101:459-471.e5 pubmed publisher
Balleza Tapia H, Crux S, Andrade Talavera Y, Dolz Gaiton P, Papadia D, Chen G, et al. TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro. elife. 2018;7: pubmed publisher
Morel C, Sherrin T, Kennedy N, Forest K, Avcioglu Barutcu S, Robles M, et al. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018;38:3708-3728 pubmed publisher
Evans A, Gurung S, Wilkinson K, Stephens D, Henley J. Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity. Cell Rep. 2017;19:2613-2626 pubmed publisher
Fletcher E, Simon C, Pagiazitis J, Chalif J, Vukojicic A, Drobac E, et al. Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. Nat Neurosci. 2017;20:905-916 pubmed publisher
Zhao Y, Zhang M, Liu H, Wang J. Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration. Neurosci Lett. 2017;651:36-42 pubmed publisher
Smith G, White J, Lugo J. Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior. Sci Rep. 2016;6:36559 pubmed publisher
Park Y, Broyles H, He S, McGrady N, Li L, Yorio T. Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation. Invest Ophthalmol Vis Sci. 2016;57:508-26 pubmed publisher
Xiao F, Xu J, Jiang X. CX3 chemokine receptor 1 deficiency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus. Neural Regen Res. 2015;10:772-7 pubmed publisher
Parrish R, Buckingham S, Mascia K, Johnson J, Matyjasik M, Lockhart R, et al. Methionine increases BDNF DNA methylation and improves memory in epilepsy. Ann Clin Transl Neurol. 2015;2:401-16 pubmed publisher
Szokol K, Heuser K, Tang W, Jensen V, Enger R, Bedner P, et al. Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Front Cell Neurosci. 2015;9:49 pubmed publisher
Spampinato S, Merlo S, Chisari M, Nicoletti F, Sortino M. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. Front Cell Neurosci. 2014;8:462 pubmed publisher
Ferando I, Mody I. In vitro gamma oscillations following partial and complete ablation of δ subunit-containing GABAA receptors from parvalbumin interneurons. Neuropharmacology. 2015;88:91-8 pubmed publisher
Domin H, Gołembiowska K, Jantas D, Kaminska K, Zieba B, Śmiałowska M. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014;26:99-113 pubmed publisher
Chang P, Walker M, Williams R. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis. 2014;62:296-306 pubmed publisher
Ferando I, Mody I. Altered gamma oscillations during pregnancy through loss of ? subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits. 2013;7:144 pubmed publisher
Bernard P, Castano A, O Leary H, Simpson K, Browning M, Benke T. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis. 2013;59:1-17 pubmed publisher
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Krook Magnuson E, Armstrong C, Oijala M, Soltesz I. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. Nat Commun. 2013;4:1376 pubmed publisher
Hou Z, Yu X. Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4. J Biol Chem. 2013;288:2501-9 pubmed publisher
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Horita H, Kobayashi M, Liu W, Oka K, Jarvis E, Wada K. Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds. PLoS ONE. 2012;7:e42173 pubmed publisher
Chuang Y, Lin T, Huang H, Chang W, Liou C, Chen S, et al. Peroxisome proliferator-activated receptors ?/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus. J Neuroinflammation. 2012;9:184 pubmed
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Peng Y, Zeng S, Song H, Li M, Yamada M, Yu X. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling. J Neurosci. 2010;30:16220-31 pubmed publisher
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product information
brand :
Tocris
master code :
222
SKU :
0222/1
product name :
Kainic acid
description :
Kainate agonist; excitant and neurotoxin
target :
Kainate Receptor Agonists
category :
Small Molecules
unit sizes :
1 mg (also 10 mg, 50 mg)
purity :
98%
observed molecular weight :
213.23
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 - 7.4 M) and a partial agonist at AMPA receptors (EC50 = 31 M - 170 M). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and A peptides in Alzheimer s disease. . Related compounds include synthetic Kainic acid (Cat. No. 7065), the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).
extended description :
Kainate agonist; excitant and neurotoxin
chemical name text :
(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
formula :
C 10 H 15 NO 4
formula text :
C10H15NO4
cas num :
487-79-6
USD :
96 USD
product details :
Kainate agonist; excitant and neurotoxin
storage :
Store at RT
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK