product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0188/1
catalog :
0188/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
133 USD
more info or order :
citations: 11
Reference
Shin S, Jeong B, Wall B, Li J, Shan N, Wen Y, et al. Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis. 2018;7:86 pubmed publisher
Scholler P, Moreno Delgado D, Lecat Guillet N, Doumazane E, Monnier C, Charrier Savournin F, et al. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 2017;13:372-380 pubmed publisher
Hu Z, Tu J. The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia. Biomed Res Int. 2015;2015:831490 pubmed publisher
El Mansari M, Lecours M, Blier P. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology (Berl). 2015;232:2343-52 pubmed publisher
El Mansari M, Manta S, Oosterhof C, El Iskandrani K, Chenu F, Shim S, et al. Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Wall B, Wangari Talbot J, Shin S, Schiff D, Sierra J, Yu L, et al. Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res. 2014;27:263-74 pubmed publisher
Ayoub M, Angelicheva D, Vile D, Chandler D, Morar B, Cavanaugh J, et al. Deleterious GRM1 mutations in schizophrenia. PLoS ONE. 2012;7:e32849 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Porter R, Jaeschke G, Spooren W, Ballard T, Büttelmann B, Kolczewski S, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005;315:711-21 pubmed
Calo L, Bruno V, Spinsanti P, Molinari G, Korkhov V, Esposito Z, et al. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci. 2005;25:2245-54 pubmed
Ferre S, Karcz Kubicha M, Hope B, Popoli P, Burgueno J, Gutiérrez M, et al. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proc Natl Acad Sci U S A. 2002;99:11940-5 pubmed
product information
master code :
188
SKU :
0188/1
product name :
L-Quisqualic acid
unit size :
1 mg (also 10 mg, 50 mg)
description :
AMPA agonist; also group I mGlu agonist
target :
AMPA Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
189.13
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called quis effect).
top caption :
AMPA agonist; also group I mGlu agonist
extended description :
AMPA agonist; also group I mGlu agonist
chemical name text :
(L)-(+)- -Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
formula :
C5H7N3O5
formula text :
C5H7N3O5
cas num :
52809-07-1
USD :
133 USD
product details :
AMPA agonist; also group I mGlu agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK