product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0169/10
catalog :
0169/10
quantity :
10 mg (also 50 mg)
price :
277 USD
more info or order :
citations: 18
Reference
Ye L, Ko C, Huang Y, Zheng C, Zheng Y, Chou D. Ketamine metabolite (2R,6R)-hydroxynorketamine enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology. 2019;157:107667 pubmed publisher
Chou D, Peng H, Lin T, Lai C, Hsieh M, Wen Y, et al. (2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology. 2018;139:1-12 pubmed publisher
Suyama S, Ralevski A, Liu Z, Dietrich M, Yada T, Simonds S, et al. Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. elife. 2017;6: pubmed publisher
Guntupalli S, Jang S, Zhu T, Huganir R, Widagdo J, Anggono V. GluA1 subunit ubiquitination mediates amyloid-?-induced loss of surface ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem. 2017;292:8186-8194 pubmed publisher
Di Angelantonio S, Bertollini C, Piccinin S, Rosito M, Trettel F, Pagani F, et al. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Front Cell Neurosci. 2015;9:409 pubmed publisher
Falgairolle M, O Donovan M. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS ONE. 2015;10:e0131430 pubmed publisher
Netzahualcoyotzi C, Tapia R. Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates. Acta Neuropathol Commun. 2015;3:27 pubmed publisher
Nygaard V, Prasmickaite L, Vasiliauskaite K, Clancy T, Hovig E. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Oncoscience. 2014;1:82-94 pubmed
Chanda S, Ang C, Davila J, Pak C, Mall M, Lee Q, et al. Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports. 2014;3:282-96 pubmed publisher
Rojas A, Wetherington J, Shaw R, Serrano G, Swanger S, Dingledine R. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 2013;83:106-21 pubmed publisher
Fakira A, Gaspers L, Thomas A, Li H, Jain M, Elkabes S. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. Mol Cell Neurosci. 2012;51:22-31 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Mahajan S, Thai K, Chen K, Ziff E. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience. 2011;189:305-15 pubmed publisher
Gangadharan V, Wang R, Ulzhöfer B, Luo C, Bardoni R, Bali K, et al. Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest. 2011;121:1608-23 pubmed publisher
Maier P, Marin I, Grampp T, Sommer A, Benke D. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem. 2010;285:35606-14 pubmed publisher
Biou V, Bhattacharyya S, Malenka R. Endocytosis and recycling of AMPA receptors lacking GluR2/3. Proc Natl Acad Sci U S A. 2008;105:1038-43 pubmed publisher
Schenk U, Verderio C, Benfenati F, Matteoli M. Regulated delivery of AMPA receptor subunits to the presynaptic membrane. EMBO J. 2003;22:558-68 pubmed
Chen W, Sulcove J, Frank I, Jaffer S, Ozdener H, Kolson D. Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptos. J Virol. 2002;76:9407-19 pubmed
product information
master code :
169
SKU :
0169/10
product name :
(RS)-AMPA
unit size :
10 mg (also 50 mg)
description :
Selective AMPA agonist
target :
AMPA Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
186.17
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( RS )-AMPA is a prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors. . Active Enantiomer, Inactive Enantiomer and Hydrobromide Salt also available.
top caption :
Selective AMPA agonist
extended description :
Selective AMPA agonist
chemical name text :
(RS)- -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
formula :
C7H10N2O4
formula text :
C7H10N2O4
cas num :
77521-29-0
USD :
277 USD
product details :
Selective AMPA agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK