product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0131/10
catalog :
0131/10
quantity :
10 mg (also 50 mg)
price :
165 USD
more info or order :
citations: 25
Reference
Pati S, Saba K, Salvi S, Tiwari P, Chaudhari P, Verma V, et al. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior. elife. 2020;9: pubmed publisher
Wagner W, Lippmann K, Heisler F, Gromova K, Lombino F, Roesler M, et al. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell Rep. 2019;28:11-20.e9 pubmed publisher
Dong W, Radulović T, Goral R, Thomas C, Suarez Montesinos M, Guerrero Given D, et al. CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep. 2018;24:284-293.e6 pubmed publisher
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman E. Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments. Neuron. 2018;98:495-511.e6 pubmed publisher
Lai Y, Choi U, Leitz J, Rhee H, Lee C, Altas B, et al. Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. Neuron. 2017;95:591-607.e10 pubmed publisher
Sigler A, Oh W, Imig C, Altas B, Kawabe H, Cooper B, et al. Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. Neuron. 2017;94:304-311.e4 pubmed publisher
Hildebrand M, Xu J, Dedek A, Li Y, Sengar A, Beggs S, et al. Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing. Cell Rep. 2016;17:2753-2765 pubmed publisher
Di Angelantonio S, Bertollini C, Piccinin S, Rosito M, Trettel F, Pagani F, et al. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Front Cell Neurosci. 2015;9:409 pubmed publisher
Jaiswal M, Keros S, Zhao M, Inan M, Schwartz T, Anderson S, et al. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Front Cell Neurosci. 2015;9:127 pubmed publisher
Dilger E, Krahe T, Morhardt D, Seabrook T, Shin H, Guido W. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci. 2015;35:3652-62 pubmed publisher
Choe K, Han S, Gaub P, Shell B, Voisin D, Knapp B, et al. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron. 2015;85:549-60 pubmed publisher
Erkens M, Tanaka Yamamoto K, Cheron G, Márquez Ruiz J, Prigogine C, Schepens J, et al. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression. Mol Brain. 2015;8:1 pubmed publisher
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Rojas A, Wetherington J, Shaw R, Serrano G, Swanger S, Dingledine R. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 2013;83:106-21 pubmed publisher
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product information
master code :
131
SKU :
0131/10
product name :
(-)-Bicuculline methochloride
unit size :
10 mg (also 50 mg)
description :
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
target :
GABA-A Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
417.85
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
(-)-Bicuculline methochloride is a methochloride salt of (+)-bicuculline . Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported. . Methoiodide Salt and Methobromide Salt also available.
top caption :
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
extended description :
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
chemical name text :
[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
formula :
C21H20ClNO6
formula text :
C21H20ClNO6
cas num :
38641-83-7
USD :
165 USD
product details :
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK