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company name :
Tocris Bioscience
product type :
chemical
product name :
0114/50
catalog :
0114/50
quantity :
50 mg (also 500 mg)
price :
128 USD
more info or order :
citations: 93
Reference
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Rodríguez Muñoz M, Onetti Y, Cortés Montero E, Garzón J, Sánchez Blázquez P. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 2018;11:51 pubmed publisher
Rodríguez Muñoz M, Sánchez Blázquez P, Garzón J. Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. 2018;9:23373-23389 pubmed publisher
Lozovaya N, Eftekhari S, Cloarec R, Gouty Colomer L, Dufour A, Riffault B, et al. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun. 2018;9:1422 pubmed publisher
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Personius K, Slusher B, Udin S. Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination. J Neurosci. 2016;36:8783-9 pubmed publisher
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Bertrand T, Lesept F, Chevilley A, Lenoir S, Aimable M, Briens A, et al. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR. Cell Death Dis. 2015;6:e1924 pubmed publisher
Rodríguez Muñoz M, Cortés Montero E, Pozo Rodrigálvarez A, Sánchez Blázquez P, Garzón Niño J. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Oncotarget. 2015;6:35458-77 pubmed publisher
Bell K, Al Mubarak B, Martel M, McKay S, Wheelan N, Hasel P, et al. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nat Commun. 2015;6:7066 pubmed publisher
El Iskandrani K, Oosterhof C, El Mansari M, Blier P. Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. J Psychopharmacol. 2015;29:792-801 pubmed publisher
Curcio M, Salazar I, Inácio A, Duarte E, Canzoniero L, Duarte C. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis. 2015;6:e1645 pubmed publisher
An K, Jung J, Jeong A, Kim H, Jung S, Lee K, et al. Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis. 2014;5:e1523 pubmed publisher
Chen J, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, et al. Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction. Nat Commun. 2014;5:5331 pubmed publisher
Garthwaite G, Hampden Smith K, Wilson G, Goodwin D, Garthwaite J. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Glia. 2015;63:383-99 pubmed publisher
Eckel R, Szulc B, Walker M, Kittler J. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity. Neuropharmacology. 2015;88:82-90 pubmed publisher
Aligny C, Roux C, Dourmap N, Ramdani Y, do Rego J, Jegou S, et al. Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice. Cell Death Dis. 2014;5:e1311 pubmed publisher
Thein S, Pham A, Bayer K, Tao Cheng J, Dosemeci A. IKK regulates the deubiquitinase CYLD at the postsynaptic density. Biochem Biophys Res Commun. 2014;450:550-4 pubmed publisher
Antoniou A, Baptista M, Carney N, Hanley J. PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity. EMBO Rep. 2014;15:548-56 pubmed publisher
Thein S, Tao Cheng J, Li Y, Bayer K, Reese T, Dosemeci A. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. PLoS ONE. 2014;9:e91312 pubmed publisher
Sánchez Blázquez P, Rodríguez Muñoz M, Herrero Labrador R, Burgueno J, Zamanillo D, Garzón J. The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol. 2014;17:1943-55 pubmed publisher
Fan X, Jin W, Lu J, Wang J, Wang Y. Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation. Nat Neurosci. 2014;17:471-80 pubmed publisher
Lee H, Lee E, Song Y, Kim E. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130158 pubmed publisher
Vicente Sánchez A, Sánchez Blázquez P, Rodríguez Muñoz M, Garzón J. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain. 2013;6:42 pubmed publisher
Hsu W, Ma Y, Hsieh D, Liu Y, Lee E. STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of A?. Neuropsychopharmacology. 2014;39:746-58 pubmed publisher
Tupone D, Madden C, Morrison S. Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat. J Neurosci. 2013;33:14512-25 pubmed publisher
Yang Y, Tao Cheng J, Bayer K, Reese T, Dosemeci A. Camkii-mediated phosphorylation regulates distributions of Syngap-?1 and -?2 at the postsynaptic density. PLoS ONE. 2013;8:e71795 pubmed publisher
Kung L, Gong K, Adedoyin M, Ng J, Bhargava A, Ohara P, et al. Evidence for glutamate as a neuroglial transmitter within sensory ganglia. PLoS ONE. 2013;8:e68312 pubmed publisher
Siddoway B, Altimimi H, Hou H, Petralia R, Xu B, Stellwagen D, et al. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci. 2013;33:11206-11 pubmed publisher
Fairless R, Beck A, Kravchenko M, Williams S, Wissenbach U, Diem R, et al. Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS ONE. 2013;8:e58260 pubmed publisher
Pooler A, Phillips E, Lau D, Noble W, Hanger D. Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep. 2013;14:389-94 pubmed publisher
Selvakumar B, Jenkins M, Hussain N, Huganir R, Traynelis S, Snyder S. S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis. Proc Natl Acad Sci U S A. 2013;110:1077-82 pubmed publisher
Pigott B, Bartus K, Garthwaite J. On the selectivity of neuronal NOS inhibitors. Br J Pharmacol. 2013;168:1255-65 pubmed publisher
Rojas A, Wetherington J, Shaw R, Serrano G, Swanger S, Dingledine R. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 2013;83:106-21 pubmed publisher
Pedrazzi M, Averna M, Sparatore B, Patrone M, Salamino F, Marcoli M, et al. Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. PLoS ONE. 2012;7:e44518 pubmed publisher
Owaisat S, Raffa R, Rawls S. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett. 2012;525:12-6 pubmed publisher
Wang H, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah S, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012;32:9773-84 pubmed publisher
Bahia P, Pugh V, Hoyland K, Hensley V, Rattray M, Williams R. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J Neurochem. 2012;123:182-91 pubmed publisher
Udagawa T, Swanger S, Takeuchi K, Kim J, Nalavadi V, Shin J, et al. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell. 2012;47:253-66 pubmed publisher
Cunningham M, Roopun A, Schofield I, Whittaker R, Duncan R, Russell A, et al. Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance. Epilepsia. 2012;53:1205-14 pubmed publisher
Niwa F, Bannai H, Arizono M, Fukatsu K, Triller A, Mikoshiba K. Gephyrin-independent GABA(A)R mobility and clustering during plasticity. PLoS ONE. 2012;7:e36148 pubmed publisher
Cassé F, Bardou I, Danglot L, Briens A, Montagne A, Parcq J, et al. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci. 2012;32:5186-99 pubmed publisher
Huang Y, Grant J, Roper S. Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. PLoS ONE. 2012;7:e30662 pubmed publisher
Beard R, Reynolds J, Bearden S. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of ?-catenin in response to homocysteine. Vascul Pharmacol. 2012;56:159-67 pubmed publisher
Hedegaard M, Hansen K, Andersen K, Brauner Osborne H, Traynelis S. Molecular pharmacology of human NMDA receptors. Neurochem Int. 2012;61:601-9 pubmed publisher
He P, Liu Q, Wu J, Shen Y. Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons. FASEB J. 2012;26:334-45 pubmed publisher
Tallarida C, Song K, Raffa R, Rawls S. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids. 2012;42:2521-4 pubmed publisher
Rodríguez Muñoz M, Sánchez Blázquez P, Vicente Sánchez A, Berrocoso E, Garzón J. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control. Neuropsychopharmacology. 2012;37:338-49 pubmed publisher
Meissirel C, Ruiz de Almodovar C, Knevels E, Coulon C, Chounlamountri N, Segura I, et al. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation. Proc Natl Acad Sci U S A. 2011;108:13782-7 pubmed publisher
Yang Y, Tao Cheng J, Reese T, Dosemeci A. SynGAP moves out of the core of the postsynaptic density upon depolarization. Neuroscience. 2011;192:132-9 pubmed publisher
Chen M, Wan Y, ADE K, Ting J, Feng G, Calakos N. Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. J Neurosci. 2011;31:9563-73 pubmed publisher
Mahajan S, Thai K, Chen K, Ziff E. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience. 2011;189:305-15 pubmed publisher
Wang Q, Green S. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro. J Neurosci. 2011;31:7938-49 pubmed publisher
Lussier M, Nasu Nishimura Y, Roche K. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. J Neurosci. 2011;31:3077-81 pubmed publisher
Li J, Ye L, Cook D, Wang X, Liu J, Kolson D, et al. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages. J Neuroinflammation. 2011;8:15 pubmed publisher
Fontainhas A, Wang M, Liang K, Chen S, Mettu P, Damani M, et al. Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission. PLoS ONE. 2011;6:e15973 pubmed publisher
Citri A, Bhattacharyya S, Ma C, Morishita W, Fang S, Rizo J, et al. Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci. 2010;30:16437-52 pubmed publisher
Ali A. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol. 2011;105:1051-62 pubmed publisher
Maier P, Marin I, Grampp T, Sommer A, Benke D. Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem. 2010;285:35606-14 pubmed publisher
Marignier R, Nicolle A, Watrin C, Touret M, Cavagna S, Varrin Doyer M, et al. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury. Brain. 2010;133:2578-91 pubmed publisher
Pansiot J, Loron G, Olivier P, Fontaine R, Charriaut Marlangue C, Mercier J, et al. Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat. PLoS ONE. 2010;5:e10916 pubmed publisher
Baron A, Montagne A, Casse F, Launay S, Maubert E, Ali C, et al. NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity. Cell Death Differ. 2010;17:860-71 pubmed publisher
Citri A, Soler Llavina G, Bhattacharyya S, Malenka R. N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system. Eur J Neurosci. 2009;30:1443-50 pubmed publisher
Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida O. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS ONE. 2009;4:e6011 pubmed publisher
Furness D, Dehnes Y, Akhtar A, Rossi D, Hamann M, Grutle N, et al. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2). Neuroscience. 2008;157:80-94 pubmed publisher
Wayman G, Davare M, Ando H, Fortin D, Varlamova O, Cheng H, et al. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A. 2008;105:9093-8 pubmed publisher
Iwasato T, Inan M, Kanki H, Erzurumlu R, Itohara S, Crair M. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development. J Neurosci. 2008;28:5931-43 pubmed publisher
Marsden K, Beattie J, Friedenthal J, Carroll R. NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. J Neurosci. 2007;27:14326-37 pubmed
Davidkova G, Carroll R. Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus. J Neurosci. 2007;27:13273-8 pubmed
Sossa K, Beattie J, Carroll R. AMPAR exocytosis through NO modulation of PICK1. Neuropharmacology. 2007;53:92-100 pubmed
Iida J, Ishizaki H, Okamoto Tanaka M, Kawata A, Sumita K, Ohgake S, et al. Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites. Mol Cell Biol. 2007;27:4388-405 pubmed
Ziskin J, Nishiyama A, Rubio M, Fukaya M, Bergles D. Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci. 2007;10:321-30 pubmed
Proudfoot C, Garry E, Cottrell D, Rosie R, Anderson H, Robertson D, et al. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol. 2006;16:1591-605 pubmed
Holman D, Feligioni M, Henley J. Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices. Neuropharmacology. 2007;52:92-9 pubmed
Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006;26:4318-28 pubmed
Smith K, Gibson E, Dell Acqua M. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. J Neurosci. 2006;26:2391-402 pubmed
Lenz G, Avruch J. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem. 2005;280:38121-4 pubmed
Yang C, Huang C, Hsu K. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci. 2005;25:4288-93 pubmed
Nakayama K, Kiyosue K, Taguchi T. Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses. J Neurosci. 2005;25:4040-51 pubmed
Lea P, Movsesyan V, Faden A. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. Br J Pharmacol. 2005;145:527-34 pubmed
Lesne S, Gabriel C, Nelson D, White E, Mackenzie E, Vivien D, et al. Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity. J Biol Chem. 2005;280:24941-7 pubmed
Srinivasan D, Yen J, Joseph D, Friedman W. Cell type-specific interleukin-1beta signaling in the CNS. J Neurosci. 2004;24:6482-8 pubmed
Kurata K, Takebayashi M, Morinobu S, Yamawaki S. beta-estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-methyl-D-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms. J Pharmacol Exp Ther. 2004;311:237-45 pubmed
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Rundfeldt C, Netzer R. Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung. 2000;50:1063-70 pubmed
O Leary D, Movsesyan V, Vicini S, Faden A. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol. 2000;131:1429-37 pubmed
Casado M, Dieudonne S, Ascher P. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Proc Natl Acad Sci U S A. 2000;97:11593-7 pubmed
product information
master code :
114
SKU :
0114/50
product name :
NMDA
unit size :
50 mg (also 500 mg)
description :
Selective NMDA agonist
target :
NMDA Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
147.13
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NMDA is a prototypic NMDA receptor agonist. . Caged version also available (Cat. No 2224).
top caption :
Selective NMDA agonist
extended description :
Selective NMDA agonist
chemical name text :
N-Methyl-D-aspartic acid
formula :
C5H9NO4
formula text :
C5H9NO4
cas num :
6384-92-5
USD :
128 USD
product details :
Selective NMDA agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK