product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
(-)-Bicuculline methobromide
catalog :
0109
quantity :
10 mg (also 50 mg)
price :
109 USD
more info or order :
citations: 15
Reference
Nam M, Han K, Lee J, Won W, Koh W, Bae J, et al. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Rep. 2019;28:1154-1166.e5 pubmed publisher
Woo J, Han Y, Koh W, Won J, Park M, An H, et al. Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol. 2019;28:30-42 pubmed publisher
Chen G, Zhang Y, Li X, Zhao X, Ye Q, Lin Y, et al. Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations. Neuron. 2017;96:1403-1418.e6 pubmed publisher
Andrade Talavera Y, Duque Feria P, Paulsen O, Rodríguez Moreno A. Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus. Cereb Cortex. 2016;26:3637-3654 pubmed publisher
Galván E, Pérez Rosello T, Gómez Lira G, Lara E, Gutiérrez R, Barrionuevo G. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons. Neuroscience. 2015;290:332-45 pubmed publisher
Maccione A, Hennig M, Gandolfo M, Muthmann O, van Coppenhagen J, Eglen S, et al. Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse. J Physiol. 2014;592:1545-63 pubmed publisher
Maguire E, Mitchell E, Greig S, Corteen N, Balfour D, Swinny J, et al. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol. Neuropsychopharmacology. 2014;39:1232-44 pubmed publisher
Johnson K, Niswender C, Conn P, Xiang Z. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata. Neurosci Lett. 2011;504:102-106 pubmed publisher
Peng Y, Zeng S, Song H, Li M, Yamada M, Yu X. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling. J Neurosci. 2010;30:16220-31 pubmed publisher
Galvan E, Cosgrove K, Mauna J, Card J, Thiels E, Meriney S, et al. Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons. J Neurosci. 2010;30:2844-55 pubmed publisher
Sipilä S, Huttu K, Yamada J, Afzalov R, Voipio J, Blaesse P, et al. Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci. 2009;29:6982-8 pubmed publisher
Huang Y, Hessler N. Social modulation during songbird courtship potentiates midbrain dopaminergic neurons. PLoS ONE. 2008;3:e3281 pubmed publisher
Krook Magnuson E, Li P, Paluszkiewicz S, Huntsman M. Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. J Neurophysiol. 2008;100:932-44 pubmed publisher
Miyazato M, Sasatomi K, Hiragata S, Sugaya K, Chancellor M, de Groat W, et al. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol. 2008;179:1178-83 pubmed publisher
Gascon E, Dayer A, Sauvain M, Potter G, Jenny B, De Roo M, et al. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci. 2006;26:12956-66 pubmed
product information
brand :
Tocris
master code :
0109
SKU :
0109/10
product name :
(-)-Bicuculline methobromide
description :
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
target :
GABA-A Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
462.3
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Methobromide salt of (+)-bicuculline . Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported. . Methoiodide Salt and Methochloride Salt also available.
catalog number base :
109
product keywords :
Water-soluble GABAA antagonists Receptors GABAA Receptors 0109,
extended description :
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
chemical name text :
[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
formula :
C 21 H 20 BrNO 6
formula text :
C21H20BrNO6
cas num :
66016-70-4
2020 USD :
103
2021 USD :
109 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK