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company name :
Tocris Bioscience
product type :
chemical
product name :
0105/10
catalog :
0105/10
quantity :
10 mg (also 50 mg)
price :
104 USD
more info or order :
citations: 97
Reference
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Wang P, Petralia R, Wang Y, Wenthold R, Brenowitz S. Functional NMDA receptors at axonal growth cones of young hippocampal neurons. J Neurosci. 2011;31:9289-97 pubmed publisher
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Zhong L, Kaleka K, Gerges N. Neurogranin phosphorylation fine-tunes long-term potentiation. Eur J Neurosci. 2011;33:244-50 pubmed publisher
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Zheng C, Petralia R, Wang Y, Kachar B, Wenthold R. SAP102 is a highly mobile MAGUK in spines. J Neurosci. 2010;30:4757-66 pubmed publisher
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product information
master code :
105
SKU :
0105/10
product name :
DL-AP5
unit size :
10 mg (also 50 mg)
description :
Potent and selective NMDA antagonist
target :
NMDA Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
197.13
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
DL-AP5 is a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons. . D-isomer, L-isomer and sodium salt also available.
top caption :
Potent and selective NMDA antagonist
extended description :
Potent and selective NMDA antagonist
chemical name text :
DL-2-Amino-5-phosphonopentanoic acid
formula :
C5H12NO5P
formula text :
C5H12NO5P
cas num :
76326-31-3
USD :
104 USD
product details :
Potent and selective NMDA antagonist
alt names :
DL -APV
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK