product summary
company name :
TRANS GENIC
product type :
antibody
product name :
Anti Human Klotho Monoclonal Antibody
catalog :
KO603
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
KM2076
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, western blot knockout validation
more info or order :
citations: 7
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:500; fig 4
  • immunohistochemistry; mouse; 1:100; fig 5
Sato S, Kawamata Y, Takahashi A, Imai Y, Hanyu A, Okuma A, et al. Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice. Nat Commun. 2015;6:7035 pubmed publisher
  • western blot knockout validation; mouse; fig 1
  • immunohistochemistry - paraffin section; mouse
  • immunocytochemistry; mouse
Lindberg K, Amin R, Moe O, Hu M, Erben R, Östman Wernerson A, et al. The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol. 2014;25:2169-75 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4f
Yamamoto K, Sato K, Yukita M, Yasuda M, Omodaka K, Ryu M, et al. The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection. J Neurochem. 2017;140:495-508 pubmed publisher
Fernández A, Sebti S, Wei Y, Zou Z, Shi M, McMillan K, et al. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 2018;558:136-140 pubmed publisher
Takeshita A, Kawakami K, Furushima K, Miyajima M, Sakaguchi K. Central role of the proximal tubular ?Klotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism. Sci Rep. 2018;8:6917 pubmed publisher
Bon N, Frangi G, Sourice S, Guicheux J, Beck Cormier S, Beck L. Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2. Mol Metab. 2018;11:197-204 pubmed publisher
Dalton G, An S, Al Juboori S, Nischan N, Yoon J, Dobrinskikh E, et al. Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling. Proc Natl Acad Sci U S A. 2017;114:752-757 pubmed publisher
company information
TRANS GENIC
infostaff@transgenic.co.jp
http://www.transgenic.co.jp
96-375-7660
headquarters: japan