product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Oligo-Abeta-pE3
catalog :
218 511
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9D5
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 7
Reference
Porcellotti S, Fanelli F, Fracassi A, Sepe S, Cecconi F, Bernardi C, et al. Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease. Oxid Med Cell Longev. 2015;2015:967203 pubmed publisher
Sieczkowski E, Milenkovic I, Venkataramani V, Giera R, Ströbel T, Höftberger R, et al. I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies. J Alzheimers Dis. 2015;44:103-14 pubmed publisher
Bayer T, Wirths O. Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease. Acta Neuropathol. 2014;127:787-801 pubmed publisher
Wirths O, Hillmann A, Pradier L, Hartig W, Bayer T. Oligomeric pyroglutamate amyloid-? is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy. J Alzheimers Dis. 2013;35:741-9 pubmed publisher
Venkataramani V, Wirths O, Budka H, Hartig W, Kovacs G, Bayer T. Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-? in a fraction of amyloid-? deposits in Alzheimer's disease without cross-reactivity with other protein aggregates. J Alzheimers Dis. 2012;29:361-71 pubmed publisher
Bayer T, Wirths O. Intraneuronal A? as a trigger for neuron loss: can this be translated into human pathology?. Biochem Soc Trans. 2011;39:857-61 pubmed publisher
Wirths O, Erck C, Martens H, Harmeier A, Geumann C, Jawhar S, et al. Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. J Biol Chem. 2010;285:41517-24 pubmed publisher
product information
Cat. Nr. :
218 511
Antigen :
Oligo-Abeta-pE3
Synonyms :
pE3-Abeta, Abeta(3(pE)-40/42), pGlu-Abeta, Abeta(3(pE)-40/42) pyro-Glu-Abeta, pyro-Glu-Abeta
Host Species :
mouse
Tpye :
monoclonal
Form :
purified IgG
Cell Line :
9D5
Subtype :
IgG2b
Immunogen :
Synthetic peptide corresponding to AA 3 to 38 from human Oligo-Abeta-pE3 (UniProt Id: P05067)
Reactivity :
human, mouse
WB :
WB
IHC :
IHC
IHC P :
IHC-P
ELISA :
ELISA
Quantity :
100 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany