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company name :
Synaptic Systems
product type :
antibody
product name :
Abeta-pE3
catalog :
218 011
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Feb 48
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 20
Reference
Nie R, Wu Z, Ni J, Zeng F, Yu W, Zhang Y, et al. Porphyromonas gingivalis Infection Induces Amyloid-β Accumulation in Monocytes/Macrophages. J Alzheimers Dis. 2019;72:479-494 pubmed publisher
Wang X, Wang L, Yu X, Li Y, Liu Z, Zou Y, et al. Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice. Int Immunopharmacol. 2019;75:105770 pubmed publisher
Murray C, Gami Patel P, Gkanatsiou E, Brinkmalm G, Portelius E, Wirths O, et al. The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease. Acta Neuropathol Commun. 2018;6:62 pubmed publisher
Schmidt F, Boltze J, Jäger C, Hofmann S, Willems N, Seeger J, et al. Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines. J Neuropathol Exp Neurol. 2015;74:912-23 pubmed publisher
Hartlage Rübsamen M, Waniek A, Meissner J, Morawski M, Schilling S, Jäger C, et al. Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease. Acta Neuropathol. 2015;129:565-83 pubmed publisher
Waniek A, Hartlage Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth H, et al. Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes. Biochim Biophys Acta. 2015;1852:146-55 pubmed publisher
Sieczkowski E, Milenkovic I, Venkataramani V, Giera R, Ströbel T, Höftberger R, et al. I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies. J Alzheimers Dis. 2015;44:103-14 pubmed publisher
Bayer T, Wirths O. Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease. Acta Neuropathol. 2014;127:787-801 pubmed publisher
Kalimo H, Lalowski M, Bogdanovic N, Philipson O, Bird T, Nochlin D, et al. The Arctic A?PP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated A?. Acta Neuropathol Commun. 2013;1:60 pubmed publisher
Morawski M, Schilling S, Kreuzberger M, Waniek A, Jäger C, Koch B, et al. Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease. J Alzheimers Dis. 2014;39:385-400 pubmed publisher
Becker A, Kohlmann S, Alexandru A, Jagla W, Canneva F, B uscher C, et al. Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration. BMC Neurosci. 2013;14:108 pubmed publisher
Wirths O, Hillmann A, Pradier L, Hartig W, Bayer T. Oligomeric pyroglutamate amyloid-? is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy. J Alzheimers Dis. 2013;35:741-9 pubmed publisher
Wittnam J, Portelius E, Zetterberg H, Gustavsson M, Schilling S, Koch B, et al. Pyroglutamate amyloid ? (A?) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease. J Biol Chem. 2012;287:8154-62 pubmed publisher
Morawski M, Brückner G, Jäger C, Seeger G, Matthews R, Arendt T. Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology. Brain Pathol. 2012;22:547-61 pubmed publisher
Hartlage Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, et al. Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-A? deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol. 2011;121:705-19 pubmed publisher
Jawhar S, Trawicka A, Jenneckens C, Bayer T, Wirths O. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal A? aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2012;33:196.e29-40 pubmed publisher
Morawski M, Hartlage Rübsamen M, Jäger C, Waniek A, Schilling S, Schwab C, et al. Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathol. 2010;120:195-207 pubmed publisher
Hartig W, Goldhammer S, Bauer U, Wegner F, Wirths O, Bayer T, et al. Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice. J Chem Neuroanat. 2010;40:82-92 pubmed publisher
Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen P, et al. Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm (Vienna). 2010;117:85-96 pubmed publisher
Wirths O, Breyhan H, Cynis H, Schilling S, Demuth H, Bayer T. Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol. 2009;118:487-96 pubmed publisher
product information
Cat. Nr. :
218 011
Antigen :
Abeta-pE3
Synonyms :
pE3-Abeta, Abeta(3(pE)-40/42), pGlu-Abeta, Abeta(3(pE)-40/42) pyro-Glu-Abeta, pyro-Glu-Abeta
Host Species :
mouse
Tpye :
monoclonal
Form :
purified IgG
Cell Line :
Feb 48
Subtype :
IgG1
Immunogen :
Synthetic peptide corresponding to AA 3 to 7 from human Abeta-pE3 (UniProt Id: P05067)
Reactivity :
human, rat, mouse, monkey
WB :
WB
IHC :
IHC
IHC P :
IHC-P
ELISA :
ELISA
Quantity :
100 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany