product summary
Loading...
company name :
Synaptic Systems
product type :
antibody
product name :
Abeta-pE3
catalog :
218 003
quantity :
50 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 6
Reference
Morawski M, Schilling S, Kreuzberger M, Waniek A, Jäger C, Koch B, et al. Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease. J Alzheimers Dis. 2014;39:385-400 pubmed publisher
Becker A, Kohlmann S, Alexandru A, Jagla W, Canneva F, B uscher C, et al. Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration. BMC Neurosci. 2013;14:108 pubmed publisher
Nussbaum J, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, et al. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-?. Nature. 2012;485:651-5 pubmed publisher
Morawski M, Brückner G, Jäger C, Seeger G, Matthews R, Arendt T. Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology. Brain Pathol. 2012;22:547-61 pubmed publisher
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, et al. Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated A? is induced by pyroglutamate-A? formation. J Neurosci. 2011;31:12790-801 pubmed publisher
Hartlage Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, et al. Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-A? deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol. 2011;121:705-19 pubmed publisher
product information
Cat. Nr. :
218 003
Antigen :
Abeta-pE3
Synonyms :
pE3-Abeta, Abeta(3(pE)-40/42), pGlu-Abeta, Abeta(3(pE)-40/42) pyro-Glu-Abeta, pyro-Glu-Abeta
Host Species :
rabbit
Tpye :
polyclonal
Form :
affinity purified
Immunogen :
Synthetic peptide corresponding to AA 3 to 7 from human Abeta-pE3 (UniProt Id: P05067)
Reactivity :
human, rat, mouse
WB :
WB
IHC :
IHC
IHC P :
IHC-P
Quantity :
50 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany