product summary
Loading...
company name :
Synaptic Systems
product type :
antibody
product name :
U1-70k
catalog :
203 011
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H111
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS, immunohistochemistry - paraffin section
more info or order :
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 2b
Behm M, Wahlstedt H, Widmark A, Eriksson M, Ohman M. Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development. J Cell Sci. 2017;130:745-753 pubmed publisher
  • western blot; mouse; fig 7
Llorian M, Gooding C, Bellora N, Hallegger M, Buckroyd A, Wang X, et al. The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators. Nucleic Acids Res. 2016;44:8933-8950 pubmed
  • western blot; human; loading ...; fig 1a
So B, Wan L, Zhang Z, Li P, Babiash E, Duan J, et al. A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange. Nat Struct Mol Biol. 2016;23:225-30 pubmed publisher
Matsueda Y, Arinuma Y, Nagai T, Hirohata S. Synergistic enhancement of production of proinflammatory cytokines of human peripheral blood monocytes by anti-Sm and anti-RNP antibodies. PLoS ONE. 2018;13:e0209282 pubmed publisher
Braun J, Friedman L, Gelles J, Moore M. Synergistic assembly of human pre-spliceosomes across introns and exons. elife. 2018;7: pubmed publisher
Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey J, et al. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. 2017;171:1545-1558.e18 pubmed publisher
Haudek K, Voss P, Wang J, Patterson R. A 10S galectin-3-U1 snRNP complex assembles into active spliceosomes. Nucleic Acids Res. 2016;44:6391-7 pubmed publisher
Merry C, Forrest M, Sabers J, Beard L, Gao X, Hatzoglou M, et al. DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer. Hum Mol Genet. 2015;24:6240-53 pubmed publisher
Rahman M, Azuma Y, Nasrin F, Takeda J, Nazim M, Bin Ahsan K, et al. SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome. Sci Rep. 2015;5:13208 pubmed publisher
Rösel Hillgärtner T, Hung L, Khrameeva E, Le Querrec P, Gelfand M, Bindereif A. A novel intra-U1 snRNP cross-regulation mechanism: alternative splicing switch links U1C and U1-70K expression. PLoS Genet. 2013;9:e1003856 pubmed publisher
Ellis J, Llères D, Denegri M, Lamond A, Cáceres J. Spatial mapping of splicing factor complexes involved in exon and intron definition. J Cell Biol. 2008;181:921-34 pubmed publisher
Howell V, Jones J, Bergren S, Li L, Billi A, Avenarius M, et al. Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum Mol Genet. 2007;16:2506-16 pubmed
Boehringer D, Makarov E, Sander B, Makarova O, Kastner B, Luhrmann R, et al. Three-dimensional structure of a pre-catalytic human spliceosomal complex B. Nat Struct Mol Biol. 2004;11:463-8 pubmed
Kameoka S, Duque P, Konarska M. p54(nrb) associates with the 5' splice site within large transcription/splicing complexes. EMBO J. 2004;23:1782-91 pubmed
Dodon M, Hamaia S, Martin J, Gazzolo L. Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element. J Biol Chem. 2002;277:18744-52 pubmed
Kues T, Dickmanns A, Luhrmann R, Peters R, Kubitscheck U. High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking. Proc Natl Acad Sci U S A. 2001;98:12021-6 pubmed
Urlaub H, Hartmuth K, Kostka S, Grelle G, Luhrmann R. A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs. J Biol Chem. 2000;275:41458-68 pubmed
product information
Cat. Nr. :
203 011
Antigen :
U1-70k
Synonyms :
snRNP70
Host Species :
mouse
Tpye :
monoclonal
Form :
purified IgG
Cell Line :
H111
Subtype :
IgG1
Immunogen :
Recombinant protein corresponding to AA 1 to 437 from human U1-70k (UniProt Id: P08621)
Reactivity :
human, rat, mouse, mammals
WB :
WB
IP :
IP
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
FACS :
FACS
Quantity :
100 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany