product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
MAP2
catalog :
188 004
quantity :
100 µl
clonality :
polyclonal
host :
guinea-pigs
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 84
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig s7h
Azarnia Tehran D, Kochlamazashvili G, Pampaloni N, Sposini S, Shergill J, Lehmann M, et al. Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity. Sci Adv. 2022;8:eabl5032 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s4k
Swarnkar S, Avchalumov Y, Espadas I, Grinman E, Liu X, Raveendra B, et al. Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation. Cell Rep. 2021;36:109369 pubmed publisher
  • immunohistochemistry; human; 1:100
Inak G, Rybak Wolf A, Lisowski P, Pentimalli T, Jüttner R, Glažar P, et al. Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome. Nat Commun. 2021;12:1929 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 5d
Courtland J, Bradshaw T, Waitt G, Soderblom E, Ho T, Rajab A, et al. Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s1b
Schiweck J, Murk K, Ledderose J, Münster Wandowski A, Ornaghi M, Vida I, et al. Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking. Nat Commun. 2021;12:1490 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:5000; fig 2b
Gordon A, Yoon S, Tran S, Makinson C, Park J, Andersen J, et al. Long-term maturation of human cortical organoids matches key early postnatal transitions. Nat Neurosci. 2021;24:331-342 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 3b
van Woerden G, Bos M, de Konink C, Distel B, Trezza R, Shur N, et al. TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development. Hum Mutat. 2021;: pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 6a
Jansch C, Ziegler G, Forero A, Gredy S, W xe4 ldchen S, Vitale M, et al. Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly. J Neural Transm (Vienna). 2021;128:225-241 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3h
Xiao L, Sharma V, Toulabi L, Yang X, Lee C, Abebe D, et al. Neurotrophic factor-α1, a novel tropin is critical for the prevention of stress-induced hippocampal CA3 cell death and cognitive dysfunction in mice: comparison to BDNF. Transl Psychiatry. 2021;11:24 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 4b
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht M, et al. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron. 2021;109:299-313.e9 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:10,000; loading ...; fig s1d
Trevino A, Sinnott Armstrong N, Andersen J, Yoon S, Huber N, Pritchard J, et al. Chromatin accessibility dynamics in a model of human forebrain development. Science. 2020;367: pubmed publisher
  • immunocytochemistry; human; 1:1000; fig s1d
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer N, Ma R, et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019;137:961-980 pubmed publisher
  • immunocytochemistry; rat; 1:500; loading ...; fig 3c
Rademacher N, Kuropka B, Kunde S, Wahl M, Freund C, Shoichet S. Intramolecular domain dynamics regulate synaptic MAGUK protein interactions. elife. 2019;8: pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 1c
Rangaraju V, Lauterbach M, Schuman E. Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity. Cell. 2019;176:73-84.e15 pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 2a
Wigerius M, Quinn D, Diab A, Clattenburg L, Kolar A, Qi J, et al. The polarity protein Angiomotin p130 controls dendritic spine maturation. J Cell Biol. 2018;217:715-730 pubmed publisher
  • immunohistochemistry; human; 1:1000; fig 1c
Birey F, Andersen J, Makinson C, Islam S, Wei W, Huber N, et al. Assembly of functionally integrated human forebrain spheroids. Nature. 2017;545:54-59 pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 1b
Rademacher N, Schmerl B, Lardong J, Wahl M, Shoichet S. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Sci Rep. 2016;6:35283 pubmed publisher
  • immunocytochemistry; human; 1:250; fig 3a,3b
Sun Y, Paşca S, Portmann T, Goold C, Worringer K, Guan W, et al. A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. elife. 2016;5: pubmed publisher
  • immunocytochemistry; mouse; fig s5
Brahic M, Bousset L, Bieri G, Melki R, Gitler A. Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1. Acta Neuropathol. 2016;131:539-48 pubmed publisher
Basak I, Harfoot R, Palmer J, Kumar A, Qui xf1 ones Mateu M, Schweitzer L, et al. Neuroproteomic Analysis after SARS-CoV-2 Infection Reveals Overrepresented Neurodegeneration Pathways and Disrupted Metabolic Pathways. Biomolecules. 2023;13: pubmed publisher
Longfield S, Mollazade M, Wallis T, Gormal R, Joensuu M, Wark J, et al. Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nat Commun. 2023;14:7277 pubmed publisher
Kim G, Nakayama L, Blum J, Akiyama T, Boeynaems S, Chakraborty M, et al. Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2. Cell Rep. 2022;41:111508 pubmed publisher
Oliveira A, Martins S, Cammarata G, Martins M, Cardoso A, Almeida M, et al. Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations. Biomedicines. 2022;10: pubmed publisher
Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, et al. Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease. Brain Neurosci Adv. 2022;6:23982128221086464 pubmed publisher
Schmerl B, Gimber N, Kuropka B, Stumpf A, Rentsch J, Kunde S, et al. The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses. PLoS Biol. 2022;20:e3001503 pubmed publisher
Sun C, Nold A, Fusco C, Rangaraju V, Tchumatchenko T, Heilemann M, et al. The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity. Sci Adv. 2021;7:eabj0790 pubmed publisher
Kour S, Rajan D, Fortuna T, Anderson E, Ward C, Lee Y, et al. Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder. Nat Commun. 2021;12:2558 pubmed publisher
Agoglia R, Sun D, Birey F, Yoon S, Miura Y, Sabatini K, et al. Primate cell fusion disentangles gene regulatory divergence in neurodevelopment. Nature. 2021;592:421-427 pubmed publisher
Bikbaev A, Ciuraszkiewicz Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, et al. Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development. J Neurosci. 2020;40:4824-4841 pubmed publisher
Tonazzini I, van Woerden G, Masciullo C, Mientjes E, Elgersma Y, Cecchini M. The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons. Mol Autism. 2019;10:41 pubmed publisher
Lu X, Yang M, Yang Y, Wang X. Atlastin-1 modulates seizure activity and neuronal excitability. CNS Neurosci Ther. 2019;: pubmed publisher
Lu C, Sanjana N. Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A). Stem Cell Res. 2019;41:101643 pubmed publisher
Urban I, Kerimoglu C, Sakib M, Wang H, Benito E, Thaller C, et al. TIP60/KAT5 is required for neuronal viability in hippocampal CA1. Sci Rep. 2019;9:16173 pubmed publisher
Frega M, Linda K, Keller J, Gümüş Akay G, Mossink B, Van Rhijn J, et al. Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling. Nat Commun. 2019;10:4928 pubmed publisher
Böger C, Hafner A, Schlichthärle T, Strauss M, Malkusch S, Endesfelder U, et al. Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography. Neurophotonics. 2019;6:035008 pubmed publisher
Yang Q, Huang Z, Luo Y, Zheng F, Hu Y, Liu H, et al. Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus. EBioMedicine. 2019;47:470-483 pubmed publisher
Fonkeu Y, Kraynyukova N, Hafner A, Kochen L, Sartori F, Schuman E, et al. How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics. Neuron. 2019;103:1109-1122.e7 pubmed publisher
Heumüller M, Glock C, Rangaraju V, Biever A, Schuman E. A genetically encodable cell-type-specific protein synthesis inhibitor. Nat Methods. 2019;16:699-702 pubmed publisher
Deshpande D, Higelin J, Schoen M, Vomhof T, Boeckers T, Demestre M, et al. Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses. Front Cell Neurosci. 2019;13:256 pubmed publisher
Vullhorst D, Buonanno A. NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release. Mol Neurobiol. 2019;: pubmed publisher
Avagliano Trezza R, Sonzogni M, Bossuyt S, Zampeta F, Punt A, van den Berg M, et al. Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome. Nat Neurosci. 2019;: pubmed publisher
Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera F, Willems E, et al. A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons. Sci Rep. 2019;9:9000 pubmed publisher
Ivankovic D, Drew J, Lesept F, White I, López Doménech G, Tooze S, et al. Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome. Autophagy. 2019;:1-17 pubmed publisher
Moore S, Alsop E, Lorenzini I, Starr A, Rabichow B, Mendez E, et al. ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathol. 2019;138:49-65 pubmed publisher
Mockett B, Guevremont D, Elder M, Parfitt K, Peppercorn K, Morrissey J, et al. Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha. J Neurosci. 2019;39:3188-3203 pubmed publisher
Bieri G, Lucin K, O Brien C, Zhang H, Villeda S, Wyss Coray T. Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Mol Neurodegener. 2018;13:68 pubmed publisher
Swarnkar S, Avchalumov Y, Raveendra B, Grinman E, Puthanveettil S. Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms. Sci Rep. 2018;8:17419 pubmed publisher
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck S, et al. The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Acta Neuropathol. 2019;137:239-257 pubmed publisher
Yang Y, Tian X, Xu D, Zheng F, Lu X, Zhang Y, et al. GPR40 modulates epileptic seizure and NMDA receptor function. Sci Adv. 2018;4:eaau2357 pubmed publisher
Elamri I, Heumüller M, Herzig L, Stirnal E, Wachtveitl J, Schuman E, et al. A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons. Chembiochem. 2018;19:2458-2464 pubmed publisher
Schmidt T, Ghaffarian N, Philippot C, Seifert G, Steinhäuser C, Pape H, et al. Differential regulation of chloride homeostasis and GABAergic transmission in the thalamus. Sci Rep. 2018;8:13929 pubmed publisher
Proietti Onori M, Koopal B, Everman D, Worthington J, Jones J, Ploeg M, et al. The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function. Hum Mutat. 2018;39:2008-2024 pubmed publisher
Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, et al. Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron. 2018;99:1155-1169.e9 pubmed publisher
Yang Q, Zheng F, Hu Y, Yang Y, Li Y, Chen G, et al. ZDHHC8 critically regulates seizure susceptibility in epilepsy. Cell Death Dis. 2018;9:795 pubmed publisher
Lieb A, Qiu Y, Dixon C, Heller J, Walker M, Schorge S, et al. Biochemical autoregulatory gene therapy for focal epilepsy. Nat Med. 2018;24:1324-1329 pubmed publisher
Lee S, Lee E, Kim R, Kim J, Lee S, Park H, et al. Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice. Front Mol Neurosci. 2018;11:209 pubmed publisher
Dörrbaum A, Kochen L, Langer J, Schuman E. Local and global influences on protein turnover in neurons and glia. elife. 2018;7: pubmed publisher
Murao N, Matsubara S, Matsuda T, Noguchi H, Mutoh T, Mutoh M, et al. Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain. Neurosci Res. 2019;143:31-43 pubmed publisher
Chia P, Zhong F, Niwa S, Bonnard C, Utami K, Zeng R, et al. A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability. elife. 2018;7: pubmed publisher
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, et al. Canonical TGF-? Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression. J Neurosci. 2018;38:4791-4810 pubmed publisher
Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman E. Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments. Neuron. 2018;98:495-511.e6 pubmed publisher
Zhang K, Daigle J, Cunningham K, Coyne A, Ruan K, Grima J, et al. Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell. 2018;173:958-971.e17 pubmed publisher
Amin H, Dipalo M, De Angelis F, Berdondini L. Biofunctionalized 3D Nanopillar Arrays Fostering Cell Guidance and Promoting Synapse Stability and Neuronal Activity in Networks. ACS Appl Mater Interfaces. 2018;10:15207-15215 pubmed publisher
Kankowski S, Förstera B, Winkelmann A, Knauff P, Wanker E, You X, et al. A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy. Front Mol Neurosci. 2017;10:439 pubmed publisher
Stamou M, Grodzki A, van Oostrum M, Wollscheid B, Lein P. Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. J Neuroinflammation. 2018;15:7 pubmed publisher
Krencik R, Seo K, van Asperen J, Basu N, Cvetkovic C, Barlas S, et al. Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes. Stem Cell Reports. 2017;9:1745-1753 pubmed publisher
Höfflin F, Jack A, Riedel C, Mack Bucher J, Roos J, Corcelli C, et al. Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex. Front Cell Neurosci. 2017;11:332 pubmed publisher
Riemann D, Wallrafen R, Dresbach T. The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein. Sci Rep. 2017;7:15791 pubmed publisher
Amin H, Marinaro F, De Pietri Tonelli D, Berdondini L. Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. Sci Rep. 2017;7:15752 pubmed publisher
Kury S, van Woerden G, Besnard T, Proietti Onori M, Latypova X, Towne M, et al. De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am J Hum Genet. 2017;101:768-788 pubmed publisher
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, et al. RNA localization is a key determinant of neurite-enriched proteome. Nat Commun. 2017;8:583 pubmed publisher
Han B, Zhou R, Xia C, Zhuang X. Structural organization of the actin-spectrin-based membrane skeleton in dendrites and soma of neurons. Proc Natl Acad Sci U S A. 2017;114:E6678-E6685 pubmed publisher
Amin H, Nieus T, Lonardoni D, Maccione A, Berdondini L. High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies. Sci Rep. 2017;7:2460 pubmed publisher
Gumy L, Katrukha E, Grigoriev I, Jaarsma D, Kapitein L, Akhmanova A, et al. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Neuron. 2017;94:347-362.e7 pubmed publisher
Grima J, Daigle J, Arbez N, Cunningham K, Zhang K, Ochaba J, et al. Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron. 2017;94:93-107.e6 pubmed publisher
Altmüller F, Pothula S, Annamneedi A, Nakhaei Rad S, Montenegro Venegas C, Pina Fernández E, et al. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genet. 2017;13:e1006684 pubmed publisher
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, et al. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron. 2017;93:854-866.e4 pubmed publisher
Quinn D, Kolar A, Wigerius M, Gomm Kolisko R, Atwi H, Fawcett J, et al. Pan-neurexin perturbation results in compromised synapse stability and a reduction in readily releasable synaptic vesicle pool size. Sci Rep. 2017;7:42920 pubmed publisher
Lam R, Töpfer F, Wood P, Busskamp V, Bamberg E. Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures. PLoS ONE. 2017;12:e0169506 pubmed publisher
Sun Q, Weinger J, Mao F, Liu G. Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration. Neuropharmacology. 2016;108:426-39 pubmed publisher
Amin H, Maccione A, Marinaro F, Zordan S, Nieus T, Berdondini L. Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays. Front Neurosci. 2016;10:121 pubmed publisher
Knackstedt L, Schwendt M. mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits. Neural Plast. 2016;2016:9312508 pubmed publisher
Deverman B, Pravdo P, Simpson B, Kumar S, Chan K, Banerjee A, et al. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nat Biotechnol. 2016;34:204-9 pubmed publisher
Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi C, Kubota K, et al. Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission. Physiol Rep. 2016;4: pubmed publisher
product information
Cat. Nr. :
188 004
Antigen :
MAP2
Synonyms :
MAP 2, MAPT
Host Species :
Guinea pig
Tpye :
polyclonal
Form :
antiserum
Immunogen :
Recombinant protein corresponding to AA 2 to 314 from human MAP2-4 hu (UniProt Id: P11137-4)
Reactivity :
human, rat, mouse
WB :
WB
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
Quantity :
100 µl
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany