product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Homer 1
catalog :
160 003
quantity :
50 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, fruit fly
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 56
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:2000; loading ...; fig 1s1b
Sando R, Sudhof T. Latrophilin GPCR signaling mediates synapse formation. elife. 2021;10: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2s1
Griffin P, Sheehan P, Dimitry J, Guo C, Kanan M, Lee J, et al. REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 6a
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer N, Ma R, et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019;137:961-980 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
  • immunohistochemistry; fruit fly ; loading ...; fig 2i
Gao R, Asano S, Upadhyayula S, Pisarev I, Milkie D, Liu T, et al. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science. 2019;363: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3e
Ciolli Mattioli C, Rom A, Franke V, Imami K, Arrey G, Terne M, et al. Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments. Nucleic Acids Res. 2019;47:2560-2573 pubmed publisher
  • immunohistochemistry; mouse; 1:800; loading ...; fig 1b
Becker L, Schnee M, Niwa M, Sun W, Maxeiner S, Talaei S, et al. The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse. elife. 2018;7: pubmed publisher
  • immunohistochemistry - frozen section; human; 1:700; loading ...; fig st1
Quadrato G, Nguyen T, Macosko E, Sherwood J, Min Yang S, Berger D, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545:48-53 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s4c
Tillberg P, Chen F, Piatkevich K, Zhao Y, Yu C, English B, et al. Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies. Nat Biotechnol. 2016;34:987-92 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig s3
Vasek M, Garber C, Dorsey D, Durrant D, Bollman B, Soung A, et al. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016;534:538-43 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Emanuele M, Esposito A, Camerini S, Antonucci F, Ferrara S, Seghezza S, et al. Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts. EBioMedicine. 2016;7:191-204 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig s3
Heise C, Schroeder J, Schoen M, Halbedl S, Reim D, Woelfle S, et al. Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus. Front Cell Neurosci. 2016;10:106 pubmed publisher
  • immunocytochemistry; mouse; fig 3
Chozinski T, Halpern A, Okawa H, Kim H, Tremel G, Wong R, et al. Expansion microscopy with conventional antibodies and fluorescent proteins. Nat Methods. 2016;13:485-8 pubmed publisher
Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, et al. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls. elife. 2019;8: pubmed publisher
Schmidl L, Schmidl G, Gawlik A, Dellith J, Hubner U, Tympel V, et al. Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology. Sci Rep. 2019;9:16110 pubmed publisher
Chakraborty T, Driscoll M, Jeffery E, Murphy M, Roudot P, Chang B, et al. Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution. Nat Methods. 2019;16:1109-1113 pubmed publisher
Kommaddi R, Tomar D, Karunakaran S, Bapat D, Nanguneri S, Ray A, et al. Glutaredoxin1 Diminishes Amyloid Beta-Mediated Oxidation of F-Actin and Reverses Cognitive Deficits in an Alzheimer's Disease Mouse Model. Antioxid Redox Signal. 2019;31:1321-1338 pubmed publisher
Dong J, Lee Y, Kirmiz M, Palacio S, Dumitras C, Moreno C, et al. A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in brain neurons. elife. 2019;8: pubmed publisher
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, et al. SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring. Neuron. 2019;: pubmed publisher
Walter A, van der Spek L, Hardy E, Bemelmans A, Rouach N, Rancillac A. Structural and functional connections between the median and the ventrolateral preoptic nucleus. Brain Struct Funct. 2019;: pubmed publisher
Lazarevic V, Mantas I, Flais I, Svenningsson P. Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex. Int J Mol Sci. 2019;20: pubmed publisher
Pennucci R, Gucciardi I, de Curtis I. Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons. PLoS ONE. 2019;14:e0220496 pubmed publisher
Trotter J, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, et al. Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters. J Cell Biol. 2019;218:2677-2698 pubmed publisher
Sanford L, Carpenter M, Palmer A. Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons. Sci Rep. 2019;9:9411 pubmed publisher
Liang H, Zhao H, GLEICHMAN A, Machnicki M, Telang S, Tang S, et al. Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Heller J, Odii T, Zheng K, Rusakov D. Imaging tripartite synapses using super-resolution microscopy. Methods. 2019;: pubmed publisher
Lee J, Lee S, Ryu Y, Lee D, Kim S, Seo J, et al. Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment. Glia. 2019;: pubmed publisher
Das M, Godoy M, Chen S, Moser V, Avalos P, Roxas K, et al. Young bone marrow transplantation preserves learning and memory in old mice. Commun Biol. 2019;2:73 pubmed publisher
Larsson M, Broman J. Synaptic Organization of VGLUT3 Expressing Low-Threshold Mechanosensitive C Fiber Terminals in the Rodent Spinal Cord. Eneuro. 2019;6: pubmed publisher
Truckenbrodt S, Sommer C, Rizzoli S, Danzl J. A practical guide to optimization in X10 expansion microscopy. Nat Protoc. 2019;14:832-863 pubmed publisher
Cromberg L, Saez T, Otero M, Tomasella E, Alloatti M, Damianich A, et al. Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors. J Neurochem. 2019;149:362-380 pubmed publisher
Lee K, Vandemark K, Mezey D, Shultz N, Fitzpatrick D. Functional Synaptic Architecture of Callosal Inputs in Mouse Primary Visual Cortex. Neuron. 2019;101:421-428.e5 pubmed publisher
Heller J, Rusakov D. A Method to Visualize the Nanoscopic Morphology of Astrocytes In Vitro and In Situ. Methods Mol Biol. 2019;1938:69-84 pubmed publisher
Ha H, Leal Ortiz S, Lalwani K, Kiyonaka S, Hamachi I, Mysore S, et al. Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. Front Mol Neurosci. 2018;11:405 pubmed publisher
Cijsouw T, Ramsey A, Lam T, Carbone B, Blanpied T, Biederer T. Mapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins. Proteomes. 2018;6: pubmed publisher
Lehrman E, Wilton D, Litvina E, Welsh C, Chang S, Frouin A, et al. CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron. 2018;100:120-134.e6 pubmed publisher
Aguayo F, Tejos Bravo M, Díaz Véliz G, Pacheco A, García Rojo G, Corrales W, et al. Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study. Front Mol Neurosci. 2018;11:283 pubmed publisher
Wang F, Yang Y, Yang N, Chen X, Huang N, Zhang J, et al. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia. Neuron. 2018;99:689-701.e5 pubmed publisher
Rosenzweig E, Brock J, Lu P, Kumamaru H, Salegio E, Kadoya K, et al. Restorative effects of human neural stem cell grafts on the primate spinal cord. Nat Med. 2018;24:484-490 pubmed publisher
Lagache T, Grassart A, Dallongeville S, Faklaris O, Sauvonnet N, Dufour A, et al. Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics. Nat Commun. 2018;9:698 pubmed publisher
Cserép C, Pósfai B, Schwarcz A, Denes A. Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites. Eneuro. 2018;5: pubmed publisher
Kommaddi R, Das D, Karunakaran S, Nanguneri S, Bapat D, Ray A, et al. Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease. J Neurosci. 2018;38:1085-1099 pubmed publisher
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, et al. RNA localization is a key determinant of neurite-enriched proteome. Nat Commun. 2017;8:583 pubmed publisher
Fiuza M, Rostosky C, Parkinson G, Bygrave A, Halemani N, Baptista M, et al. PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. J Cell Biol. 2017;216:3323-3338 pubmed publisher
Ouwenga R, Lake A, O BRIEN D, Mogha A, Dani A, Dougherty J. Transcriptomic Analysis of Ribosome-Bound mRNA in Cortical Neurites In Vivo. J Neurosci. 2017;37:8688-8705 pubmed publisher
Chang J, Chen F, Yoon Y, Jung E, Babcock H, Kang J, et al. Iterative expansion microscopy. Nat Methods. 2017;14:593-599 pubmed publisher
Altmüller F, Pothula S, Annamneedi A, Nakhaei Rad S, Montenegro Venegas C, Pina Fernández E, et al. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genet. 2017;13:e1006684 pubmed publisher
Espuny Camacho I, Arranz A, Fiers M, Snellinx A, Ando K, Munck S, et al. Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron. 2017;93:1066-1081.e8 pubmed publisher
Okerlund N, Schneider K, Leal Ortiz S, Montenegro Venegas C, Kim S, Garner L, et al. Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 2017;93:897-913.e7 pubmed publisher
Diering G, Nirujogi R, Roth R, Worley P, Pandey A, Huganir R. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 2017;355:511-515 pubmed publisher
Abraira V, Kuehn E, Chirila A, Springel M, Toliver A, Zimmerman A, et al. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017;168:295-310.e19 pubmed publisher
Acuna C, Liu X, Sudhof T. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 2016;91:792-807 pubmed publisher
Chailangkarn T, Trujillo C, Freitas B, Hrvoj Mihic B, Herai R, Yu D, et al. A human neurodevelopmental model for Williams syndrome. Nature. 2016;536:338-43 pubmed
Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P. Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure. Sci Rep. 2016;6:27400 pubmed publisher
Sidenstein S, D Este E, Böhm M, Danzl J, Belov V, Hell S. Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses. Sci Rep. 2016;6:26725 pubmed publisher
Gutierrez Mecinas M, Kuehn E, Abraira V, Polgár E, Watanabe M, Todd A. Immunostaining for Homer reveals the majority of excitatory synapses in laminae I-III of the mouse spinal dorsal horn. Neuroscience. 2016;329:171-81 pubmed publisher
Glebov O, Cox S, Humphreys L, Burrone J. Neuronal activity controls transsynaptic geometry. Sci Rep. 2016;6:22703 pubmed publisher
product information
Cat. Nr. :
160 003
Antigen :
Homer 1
Synonyms :
VesL 1, Syn47, Homer 1, Homer 1a, Homer1
Host Species :
rabbit
Tpye :
polyclonal
Form :
affinity purified
Immunogen :
Recombinant protein corresponding to AA 1 to 196 from human Homer1 (UniProt Id: Q86YM7)
Reactivity :
human, rat, mouse
WB :
WB
IP :
IP
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
ELISA :
ELISA
Quantity :
50 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany