product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Arc
catalog :
156 003
quantity :
50 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunocytochemistry knockout validation
more info or order :
citations: 42
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; mouse; fig s4c
Pastuzyn E, Day C, Kearns R, Kyrke Smith M, Taibi A, McCormick J, et al. The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell. 2018;172:275-288.e18 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 2
  • western blot; mouse; 1:6000; loading ...; fig 2, 5
Gulmez Karaca K, Kupke J, Brito D, Zeuch B, Thome C, Weichenhan D, et al. Neuronal ensemble-specific DNA methylation strengthens engram stability. Nat Commun. 2020;11:639 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3a
Song J, Shao D, Guo X, Zhao Y, Cui D, Ma Q, et al. Crucial role of feedback signals from prelimbic cortex to basolateral amygdala in the retrieval of morphine withdrawal memory. Sci Adv. 2019;5:eaat3210 pubmed publisher
  • western blot; mouse; fig 7
Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig s1
Nakayama D, Hashikawa Yamasaki Y, Ikegaya Y, Matsuki N, Nomura H. Late Arc/Arg3.1 expression in the basolateral amygdala is essential for persistence of newly-acquired and reactivated contextual fear memories. Sci Rep. 2016;6:21007 pubmed publisher
  • western blot; rat; 1:500; fig 4
Vincent K, Cornea V, Jong Y, Laferriere A, Kumar N, Mickeviciute A, et al. Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun. 2016;7:10604 pubmed publisher
Ishizuka Y, Mergiya T, Baldinotti R, Xu J, Hallin E, Markússon S, et al. Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function. Neurochem Res. 2022;: pubmed publisher
Paul M, Choi M, Schlaudraff J, Deller T, Del Turco D. Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior. Cereb Cortex. 2019;: pubmed publisher
Klein M, Younts T, Cobo C, Buxbaum A, Aow J, Erdjument Bromage H, et al. Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons. Cell Rep. 2019;29:1789-1799.e6 pubmed publisher
Yu Taeger L, Ott T, Bonsi P, Tomczak C, Wassouf Z, Martella G, et al. Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia. Neurobiol Dis. 2019;134:104634 pubmed publisher
Bessières B, Jia M, Travaglia A, Alberini C. Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat basolateral amygdala. Learn Mem. 2019;26:436-448 pubmed publisher
Gao X, Grendel J, Muhia M, Castro Gomez S, Süsens U, Isbrandt D, et al. Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice. J Neurosci. 2019;: pubmed publisher
Descalzi G, Gao V, Steinman M, Suzuki A, Alberini C. Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons. Commun Biol. 2019;2:247 pubmed publisher
González Franco D, Bello Medina P, Serafin N, Prado Alcalá R, Quirarte G. Effects of anisomycin infusions into the dorsal striatum on memory consolidation of intense training and neurotransmitter activity. Brain Res Bull. 2019;150:250-260 pubmed publisher
Turner J, Will R, Harvey E, Hattori T, Tobiansky D, Nutsch V, et al. Copulation induces expression of the immediate early gene Arc in mating-relevant brain regions of the male rat. Behav Brain Res. 2019;:112006 pubmed publisher
Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R. Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors. Sci Rep. 2019;9:8251 pubmed publisher
Terreros Roncal J, Flor García M, Moreno Jiménez E, Pallas Bazarra N, Rabano A, Sah N, et al. Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia. J Neurosci. 2019;: pubmed publisher
Holter M, Hewitt L, Koebele S, Judd J, Xing L, Bimonte Nelson H, et al. The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning. PLoS Genet. 2019;15:e1008108 pubmed publisher
Gobin C, Shallcross J, Schwendt M. Neurobiological substrates of persistent working memory deficits and cocaine-seeking in the prelimbic cortex of rats with a history of extended access to cocaine self-administration. Neurobiol Learn Mem. 2019;161:92-105 pubmed publisher
Ryu H, Seo J, Jung Y, Kim S, Kim E, Jang S, et al. Upf1 regulates neurite outgrowth and branching by transcriptional and post-transcriptional modulation of Arc. J Cell Sci. 2019;132: pubmed publisher
Jia M, Travaglia A, Pollonini G, Fedele G, Alberini C. Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat medial prefrontal cortex. Learn Mem. 2018;25:533-543 pubmed publisher
Jacobs C, Badiee R, Lin M. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat Methods. 2018;15:523-526 pubmed publisher
Wall M, Collins D, Chery S, Allen Z, Pastuzyn E, George A, et al. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility. Neuron. 2018;98:1124-1132.e7 pubmed publisher
Tyssowski K, DeStefino N, Cho J, Dunn C, Poston R, Carty C, et al. Different Neuronal Activity Patterns Induce Different Gene Expression Programs. Neuron. 2018;98:530-546.e11 pubmed publisher
Brockett A, Kane G, Monari P, Briones B, Vigneron P, Barber G, et al. Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca2+ binding protein S100?. PLoS ONE. 2018;13:e0195726 pubmed publisher
Carmichael R, Wilkinson K, Craig T, Ashby M, Henley J. MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1. Sci Rep. 2018;8:5263 pubmed publisher
Steward O, Matsudaira Yee K, Farris S, Pirbhoy P, Worley P, Okamura K, et al. Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice. Front Mol Neurosci. 2017;10:435 pubmed publisher
Dunn C, Sarkar P, Bailey E, Farris S, Zhao M, Ward J, et al. Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes. Eneuro. 2017;4: pubmed publisher
Kim C, Ye L, Jennings J, Pichamoorthy N, Tang D, Yoo A, et al. Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking. Cell. 2017;170:1013-1027.e14 pubmed publisher
Jenks K, Kim T, Pastuzyn E, Okuno H, Taibi A, Bito H, et al. Arc restores juvenile plasticity in adult mouse visual cortex. Proc Natl Acad Sci U S A. 2017;114:9182-9187 pubmed publisher
Cansler H, Maksimova M, Meeks J. Experience-Dependent Plasticity in Accessory Olfactory Bulb Interneurons following Male-Male Social Interaction. J Neurosci. 2017;37:7240-7252 pubmed publisher
Bernier B, Lacagnina A, Ayoub A, Shue F, Zemelman B, Krasne F, et al. Dentate Gyrus Contributes to Retrieval as well as Encoding: Evidence from Context Fear Conditioning, Recall, and Extinction. J Neurosci. 2017;37:6359-6371 pubmed publisher
Pernía M, Estevez S, Poveda C, Plaza I, Carro J, Juiz J, et al. c-Fos and Arc/Arg3.1 expression in auditory and visual cortices after hearing loss: Evidence of sensory crossmodal reorganization in adult rats. J Comp Neurol. 2017;525:2677-2689 pubmed publisher
Frank R, Zhu F, Komiyama N, Grant S. Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes. J Neurochem. 2017;142:504-511 pubmed publisher
Del Cid Pellitero E, Plavski A, Mainville L, Jones B. Homeostatic Changes in GABA and Glutamate Receptors on Excitatory Cortical Neurons during Sleep Deprivation and Recovery. Front Syst Neurosci. 2017;11:17 pubmed publisher
Jaitner C, Reddy C, Abentung A, Whittle N, Rieder D, Delekate A, et al. Satb2 determines miRNA expression and long-term memory in the adult central nervous system. elife. 2016;5: pubmed publisher
Lempel A, Coll L, Schinder A, Uchitel O, Piriz J. Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells. J Neurochem. 2017;140:257-267 pubmed publisher
daSilva L, Wall M, P de Almeida L, Wauters S, Januário Y, Muller J, et al. Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2. Eneuro. 2016;3: pubmed publisher
Sethna F, Zhang M, Kaphzan H, Klann E, Autio D, Cox C, et al. Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res. 2016;94:401-8 pubmed publisher
Chumak T, Rüttiger L, Lee S, Campanelli D, Zuccotti A, Singer W, et al. BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury. Mol Neurobiol. 2016;53:5607-27 pubmed publisher
Gröger N, Bock J, Goehler D, Blume N, Lisson N, Poeggel G, et al. Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner. Brain Struct Funct. 2016;221:679-85 pubmed publisher
Liu J, Supnet C, Sun S, Zhang H, Good L, Popugaeva E, et al. The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease. Channels (Austin). 2014;8:230-42 pubmed
product information
Cat. Nr. :
156 003
Antigen :
Arc
Synonyms :
Arg 3.1
Host Species :
rabbit
Tpye :
polyclonal
Form :
affinity purified
Immunogen :
Recombinant protein corresponding to AA 1 to 396 from mouse Arc (UniProt Id: Q9WV31)
Reactivity :
rat, mouse
WB :
WB
IP :
IP
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
ELISA :
ELISA
KO :
yes
KD :
yes
Quantity :
50 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany