product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
RIM 1/2
catalog :
140 203
quantity :
50 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
human, mouse, rat, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, other
more info or order :
citations: 20
Published Application/Species/Sample/DilutionReference
  • other; mouse; 1:2000; fig 3
Lenkey N, Kirizs T, Holderith N, Máté Z, Szabó G, Vizi E, et al. Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals. Nat Commun. 2015;6:6557 pubmed publisher
Crosby K, Gookin S, Garcia J, Hahm K, Dell Acqua M, Smith K. Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse. Cell Rep. 2019;26:3284-3297.e3 pubmed publisher
Lazarevic V, Yang Y, Ivanova D, Fejtova A, Svenningsson P. Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool. Neuropharmacology. 2018;143:38-48 pubmed publisher
Emperador Melero J, Huson V, Van Weering J, Bollmann C, Fischer von Mollard G, Toonen R, et al. Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Nat Commun. 2018;9:3421 pubmed publisher
Funahashi J, Tanaka H, Hirano T. Visualization of Synchronous or Asynchronous Release of Single Synaptic Vesicle in Active-Zone-Like Membrane Formed on Neuroligin-Coated Glass Surface. Front Cell Neurosci. 2018;12:140 pubmed publisher
Szoboszlay M, Kirizs T, Nusser Z. Objective quantification of nanoscale protein distributions. Sci Rep. 2017;7:15240 pubmed publisher
Glebov O, Jackson R, Winterflood C, Owen D, Barker E, Doherty P, et al. Nanoscale Structural Plasticity of the Active Zone Matrix Modulates Presynaptic Function. Cell Rep. 2017;18:2715-2728 pubmed publisher
Quinn D, Kolar A, Wigerius M, Gomm Kolisko R, Atwi H, Fawcett J, et al. Pan-neurexin perturbation results in compromised synapse stability and a reduction in readily releasable synaptic vesicle pool size. Sci Rep. 2017;7:42920 pubmed publisher
Grauel M, Maglione M, Reddy Alla S, Willmes C, Brockmann M, Trimbuch T, et al. RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proc Natl Acad Sci U S A. 2016;113:11615-11620 pubmed
Tang A, Chen H, Li T, Metzbower S, MacGillavry H, Blanpied T. A trans-synaptic nanocolumn aligns neurotransmitter release to receptors. Nature. 2016;536:210-4 pubmed
Althof D, Baehrens D, Watanabe M, Suzuki N, Fakler B, Kulik A. Inhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca(2+) channels. Front Cell Neurosci. 2015;9:315 pubmed publisher
Gardezi S, Li Q, Stanley E. Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain. Biol Open. 2013;2:492-8 pubmed publisher
Spangler S, Schmitz S, Kevenaar J, de Graaff E, de Wit H, Demmers J, et al. Liprin-?2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. J Cell Biol. 2013;201:915-28 pubmed publisher
Tom Dieck S, Specht D, Strenzke N, Hida Y, Krishnamoorthy V, Schmidt K, et al. Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing. J Neurosci. 2012;32:12192-203 pubmed
Holderith N, Lorincz A, Katona G, Rózsa B, Kulik A, Watanabe M, et al. Release probability of hippocampal glutamatergic terminals scales with the size of the active zone. Nat Neurosci. 2012;15:988-97 pubmed publisher
Bello O, Zanetti M, Mayorga L, Michaut M. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis. Exp Cell Res. 2012;318:478-88 pubmed publisher
Lazarevic V, Sch ne C, Heine M, Gundelfinger E, Fejtova A. Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. J Neurosci. 2011;31:10189-200 pubmed publisher
Hua Y, Sinha R, Thiel C, Schmidt R, Hüve J, Martens H, et al. A readily retrievable pool of synaptic vesicles. Nat Neurosci. 2011;14:833-9 pubmed publisher
Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, et al. Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. J Biol Chem. 2010;285:21750-67 pubmed publisher
Wong F, Stanley E. Rab3a interacting molecule (RIM) and the tethering of pre-synaptic transmitter release site-associated CaV2.2 calcium channels. J Neurochem. 2010;112:463-73 pubmed publisher
product information
Company Name :
Synaptic Systems
Cat. Nr. :
140 203
Antigen :
RIM 1/2
Synonyms :
Rim2, Active Zone, CAZ
Host Species :
rabbit
Tpye :
polyclonal
Form :
affinity purified 2
add. Info :
Zn-finger domain
Immunogen :
Recombinant protein corresponding to AA 1 to 466 from rat Rim2 (UniProt Id: Q9JIS1)
Reactivity :
human, rat, mouse, zebrafish
WB :
y
IP :
y
ICC :
y
IHC :
y
IHC P :
y
EM :
y
Quantity :
50 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany