product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
VGAT
catalog :
131 004
quantity :
100 µl
clonality :
polyclonal
host :
guinea-pigs
conjugate :
nonconjugated
reactivity :
African green monkey, human, mouse, rat, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 78
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; African green monkey; 1:400; loading ...; fig 7f
Tsolias A, Medalla M. Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey. Front Neural Circuits. 2021;15:795325 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 6b
Tate K, Kirk B, Tseng A, Ulffers A, LITWA K. Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex. Int J Mol Sci. 2021;22: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4a
Komorowska Müller J, Ravichandran K, Zimmer A, Schürmann B. Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus. Sci Rep. 2021;11:16828 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1a
Guo C, Rudolph S, Neuwirth M, Regehr W. Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex. elife. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4i
Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, et al. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021;36:109362 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 1f
Magno L, Asgarian Z, Pendolino V, Velona T, Mackintosh A, Lee F, et al. Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior. Cell Rep. 2021;35:109249 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1b
Turecek J, Regehr W. Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6a
Wu Z, Parry M, Hou X, Liu M, Wang H, Cain R, et al. Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease. Nat Commun. 2020;11:1105 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 1b
Pelkey K, Calvigioni D, Fang C, Vargish G, Ekins T, Auville K, et al. Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons. elife. 2020;9: pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 1e
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5j
Katona L, Hartwich K, Tomioka R, Somogyi J, Roberts J, Wagner K, et al. Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum. Brain Struct Funct. 2020;225:705-734 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 4b
Burrus C, McKinstry S, Kim N, Ozlu M, Santoki A, Fang F, et al. Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival. Cell Rep. 2020;30:642-657.e6 pubmed publisher
  • immunocytochemistry; mouse; 1:1500; loading ...; fig 3a
Duan J, Pandey S, Li T, Castellano D, Gu X, Li J, et al. Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development. Front Cell Neurosci. 2019;13:217 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1c
Szonyi A, Sos K, Nyilas R, Schlingloff D, Domonkos A, Takács V, et al. Brainstem nucleus incertus controls contextual memory formation. Science. 2019;364: pubmed publisher
  • immunocytochemistry; mouse; 1:300; loading ...; fig 3c
Upadhyay A, Hosseinibarkooie S, Schneider S, Kaczmarek A, Torres Benito L, Mendoza Ferreira N, et al. Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological. Front Mol Neurosci. 2019;12:19 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig s2a
Turecek J, Jackman S, Regehr W. Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses. Nature. 2017;551:503-506 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4b
Martenson J, Yamasaki T, Chaudhury N, Albrecht D, Tomita S. Assembly rules for GABAA receptor complexes in the brain. elife. 2017;6: pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig 2a
Bouhours B, Gjoni E, Kochubey O, Schneggenburger R. Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons. J Neurosci. 2017;37:4604-4617 pubmed publisher
  • immunohistochemistry; mouse; 1 ug/ml; loading ...; fig 4c
Sohn J, Okamoto S, Kataoka N, Kaneko T, Nakamura K, Hioki H. Differential Inputs to the Perisomatic and Distal-Dendritic Compartments of VIP-Positive Neurons in Layer 2/3 of the Mouse Barrel Cortex. Front Neuroanat. 2016;10:124 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig s5a
Redmond S, Mei F, Eshed Eisenbach Y, Osso L, Leshkowitz D, Shen Y, et al. Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination. Neuron. 2016;91:824-836 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; fig 4
Rossi M, Li H, Lu D, Kim I, Bartholomew R, Gaidis E, et al. A GABAergic nigrotectal pathway for coordination of drinking behavior. Nat Neurosci. 2016;19:742-748 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 6
Gao Y, Heldt S. Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences. Front Cell Neurosci. 2016;10:39 pubmed publisher
  • immunocytochemistry; mouse; 1:700; tbl 1
Hirata H, Umemori J, Yoshioka H, Koide T, Watanabe K, Shimoda Y. Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages. J Neurosci Res. 2016;94:74-89 pubmed publisher
Gil Miravet I, Melchor Eixea I, Arias Sandoval E, Vásquez Celaya L, Guarque Chabrera J, Olucha Bordonau F, et al. From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine-related cues. Addict Biol. 2019;:e12834 pubmed publisher
Vukojicic A, Delestrée N, Fletcher E, Pagiazitis J, Sankaranarayanan S, Yednock T, et al. The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA. Cell Rep. 2019;29:3087-3100.e7 pubmed publisher
Shimell J, Shah B, Cain S, Thouta S, Kuhlmann N, Tatarnikov I, et al. The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation. Cell Rep. 2019;29:2422-2437.e8 pubmed publisher
Handara G, Kroger S. Alternative Splicing and the Intracellular Domain Mediate TM-agrin's Ability to Differentially Regulate the Density of Excitatory and Inhibitory Synapse-like Specializations in Developing CNS Neurons. Neuroscience. 2019;419:60-71 pubmed publisher
Zhang X, François U, Silm K, Angelo M, Fernandez Busch M, Maged M, et al. A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency. elife. 2019;8: pubmed publisher
Miralles C, Taylor M, Bear J, Fekete C, George S, Li Y, et al. Expression of protocadherin-γC4 protein in the rat brain. J Comp Neurol. 2019;: pubmed publisher
Gottschling C, Wegrzyn D, Denecke B, Faissner A. Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses. Sci Rep. 2019;9:13939 pubmed publisher
Nathanson A, Zhang Y, Smalley J, Ollerhead T, Rodriguez Santos M, Andrews P, et al. Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures. Cell Rep. 2019;28:670-681.e8 pubmed publisher
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, et al. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep. 2019;28:625-639.e6 pubmed publisher
Gao Y, Hisey E, Bradshaw T, Erata E, Brown W, Courtland J, et al. Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering. Neuron. 2019;: pubmed publisher
Meijer M, Rehbach K, Brunner J, Classen J, Lammertse H, van Linge L, et al. A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons. Cell Rep. 2019;27:2199-2211.e6 pubmed publisher
Duan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, et al. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice. Aging (Albany NY). 2019;11:2457-2476 pubmed publisher
Salib M, Joshi A, Katona L, Howarth M, Micklem B, Somogyi P, et al. GABAergic Medial Septal Neurons with Low-Rhythmic Firing Innervating the Dentate Gyrus and Hippocampal Area CA3. J Neurosci. 2019;39:4527-4549 pubmed publisher
Kroon T, van Hugte E, van Linge L, Mansvelder H, Meredith R. Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex. Sci Rep. 2019;9:5037 pubmed publisher
Tai Y, Gallo N, Wang M, Yu J, Van Aelst L. Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM. Neuron. 2019;102:358-372.e9 pubmed publisher
Boccalaro I, Cristiá Lara L, Schwerdel C, Fritschy J, Rubi L. Cell type-specific distribution of GABAA receptor subtypes in the mouse dorsal striatum. J Comp Neurol. 2019;527:2030-2046 pubmed publisher
Brown A, Arancillo M, Lin T, Catt D, Zhou J, Lackey E, et al. Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells. Sci Rep. 2019;9:1742 pubmed publisher
Turecek J, Regehr W. Neuronal Regulation of Fast Synaptotagmin Isoforms Controls the Relative Contributions of Synchronous and Asynchronous Release. Neuron. 2019;101:938-949.e4 pubmed publisher
Bragado Alonso S, Reinert J, Marichal N, Massalini S, Berninger B, Kuner T, et al. An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants. EMBO J. 2019;38: pubmed publisher
Sprenger H, Wani G, Hesseling A, König T, Patron M, MacVicar T, et al. Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019;11: pubmed publisher
Hammond J, Qiu W, Marker D, Chamberlain J, Greaves Tunnell W, Bellizzi M, et al. HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q. Glia. 2018;66:2563-2574 pubmed publisher
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, et al. A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation. Nat Commun. 2018;9:3979 pubmed publisher
Bragina L, Conti F. Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses. Front Neuroanat. 2018;12:74 pubmed publisher
Edamatsu M, Miyano R, Fujikawa A, Fujii F, Hori T, Sakaba T, et al. Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons. J Neurochem. 2018;147:748-763 pubmed publisher
Hartzell A, Martyniuk K, Brigidi G, Heinz D, Djaja N, Payne A, et al. NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus. elife. 2018;7: pubmed publisher
Gjoni E, Zenke F, Bouhours B, Schneggenburger R. Specific synaptic input strengths determine the computational properties of excitation-inhibition integration in a sound localization circuit. J Physiol. 2018;596:4945-4967 pubmed publisher
Rhomberg T, Rovira Esteban L, Vikór A, Paradiso E, Kremser C, Nagy Pál P, et al. Vasoactive Intestinal Polypeptide-Immunoreactive Interneurons within Circuits of the Mouse Basolateral Amygdala. J Neurosci. 2018;38:6983-7003 pubmed publisher
Jaarsma D, Blot F, Wu B, Venkatesan S, Voogd J, Meijer D, et al. The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer. J Comp Neurol. 2018;526:2231-2256 pubmed publisher
Jiang D, Wu Z, Forsyth C, Hu Y, Yee S, Chen G. GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation. Mol Brain. 2018;11:31 pubmed publisher
Hioki H, Sohn J, Nakamura H, Okamoto S, Hwang J, Ishida Y, et al. Preferential inputs from cholecystokinin-positive neurons to the somatic compartment of parvalbumin-expressing neurons in the mouse primary somatosensory cortex. Brain Res. 2018;1695:18-30 pubmed publisher
Cerveró C, Blasco A, Tarabal O, Casanovas A, Piedrafita L, Navarro X, et al. Glial Activation and Central Synapse Loss, but Not Motoneuron Degeneration, Are Prevented by the Sigma-1 Receptor Agonist PRE-084 in the Smn2B/- Mouse Model of Spinal Muscular Atrophy. J Neuropathol Exp Neurol. 2018;77:577-597 pubmed publisher
Lozovaya N, Eftekhari S, Cloarec R, Gouty Colomer L, Dufour A, Riffault B, et al. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun. 2018;9:1422 pubmed publisher
Viney T, Salib M, Joshi A, Unal G, Berry N, Somogyi P. Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum. elife. 2018;7: pubmed publisher
de Jong A, Roggero C, Ho M, Wong M, Brautigam C, Rizo J, et al. RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes. Neuron. 2018;98:335-349.e7 pubmed publisher
Simões A, Silva C, Marques J, Pochmann D, Porciúncula L, Ferreira S, et al. Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation. Cell Death Dis. 2018;9:297 pubmed publisher
Ge Y, Kang Y, Cassidy R, Moon K, Lewis R, Wong R, et al. Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength. Neuron. 2018;97:596-610.e8 pubmed publisher
Cserép C, Pósfai B, Schwarcz A, Denes A. Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites. Eneuro. 2018;5: pubmed publisher
Koch S, Del Barrio M, Dalet A, Gatto G, Gunther T, Zhang J, et al. RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait. Neuron. 2017;96:1419-1431.e5 pubmed publisher
Joshi A, Salib M, Viney T, Dupret D, Somogyi P. Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area. Neuron. 2017;96:1342-1357.e5 pubmed publisher
Li J, Han W, Pelkey K, Duan J, Mao X, Wang Y, et al. Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development. Neuron. 2017;96:808-826.e8 pubmed publisher
Anderson G, Maxeiner S, Sando R, Tsetsenis T, Malenka R, Südhof T. Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. J Cell Biol. 2017;216:3831-3846 pubmed publisher
Dzyubenko E, Juckel G, Faissner A. The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro. Sci Rep. 2017;7:11609 pubmed publisher
Barrows C, McCabe M, Chen H, Swann J, Weston M. PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network. J Neurosci. 2017;37:8595-8611 pubmed publisher
Laperchia C, Imperatore R, Azeez I, Del Gallo F, Bertini G, Grassi Zucconi G, et al. The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization. Brain Struct Funct. 2017;222:3847-3859 pubmed publisher
Birey F, Andersen J, Makinson C, Islam S, Wei W, Huber N, et al. Assembly of functionally integrated human forebrain spheroids. Nature. 2017;545:54-59 pubmed publisher
Medalla M, Gilman J, Wang J, Luebke J. Strength and Diversity of Inhibitory Signaling Differentiates Primate Anterior Cingulate from Lateral Prefrontal Cortex. J Neurosci. 2017;37:4717-4734 pubmed publisher
Nakahata Y, Eto K, Murakoshi H, Watanabe M, Kuriu T, Hirata H, et al. Activation-Dependent Rapid Postsynaptic Clustering of Glycine Receptors in Mature Spinal Cord Neurons. Eneuro. 2017;4: pubmed publisher
Casanovas A, Salvany S, Lahoz V, Tarabal O, Piedrafita L, Sabater R, et al. Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury. Sci Rep. 2017;7:40155 pubmed publisher
Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert H, et al. Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration. Proc Natl Acad Sci U S A. 2017;114:E209-E218 pubmed publisher
Catuara Solarz S, Espinosa Carrasco J, Erb I, Langohr K, Gonzalez J, Notredame C, et al. Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome. Eneuro. 2016;3: pubmed
Fekete C, Goz R, Dinallo S, Miralles C, Chiou T, Bear J, et al. In vivo transgenic expression of collybistin in neurons of the rat cerebral cortex. J Comp Neurol. 2017;525:1291-1311 pubmed publisher
Held R, Liu C, Kaeser P. ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains. elife. 2016;5: pubmed publisher
Bhattacharya S, Herrera Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, et al. Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation. Biol Psychiatry. 2017;81:124-135 pubmed publisher
Armstrong C, Wang J, Yeun Lee S, Broderick J, Bezaire M, Lee S, et al. Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals. Hippocampus. 2016;26:779-93 pubmed publisher
Faralli A, Dagna F, Albera A, Bekku Y, Oohashi T, Albera R, et al. Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse. Brain Struct Funct. 2016;221:3193-209 pubmed publisher
Orduz D, Maldonado P, Balia M, Vélez Fort M, de Sars V, Yanagawa Y, et al. Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex. elife. 2015;4: pubmed publisher
product information
Cat. Nr. :
131 004
Antigen :
VGAT
Synonyms :
VIAAT, SLC32A1
Host Species :
Guinea pig
Tpye :
polyclonal
Form :
antiserum
Immunogen :
Recombinant protein corresponding to AA 2 to 115 from rat VGAT (UniProt Id: O35458)
Reactivity :
rat, mouse, zebrafish, ape
WB :
WB
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
EM :
EM
KO :
yes
Quantity :
100 µl
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany