product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Munc 13-1
catalog :
126 103
quantity :
50 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
human, mouse, rat, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
citations: 24
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; fig s5e
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser P. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018;172:706-718.e15 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 1a, 1f
Man K, Imig C, Walter A, Pinheiro P, Stevens D, Rettig J, et al. Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. elife. 2015;4: pubmed publisher
Fenske P, Grauel M, Brockmann M, Dorrn A, Trimbuch T, Rosenmund C. Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology. Sci Rep. 2019;9:4890 pubmed publisher
Lazarevic V, Yang Y, Ivanova D, Fejtova A, Svenningsson P. Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool. Neuropharmacology. 2018;143:38-48 pubmed publisher
Wang J, Lv X, Wu Y, Xu T, Jiao M, Yang R, et al. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons. Nat Commun. 2018;9:2267 pubmed publisher
Funahashi J, Tanaka H, Hirano T. Visualization of Synchronous or Asynchronous Release of Single Synaptic Vesicle in Active-Zone-Like Membrane Formed on Neuroligin-Coated Glass Surface. Front Cell Neurosci. 2018;12:140 pubmed publisher
de Jong A, Roggero C, Ho M, Wong M, Brautigam C, Rizo J, et al. RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes. Neuron. 2018;98:335-349.e7 pubmed publisher
Higashio H, Satoh Y, Saino T. Inhibitory role of Munc13-1 in antigen-induced mast cell degranulation. Biomed Res. 2017;38:321-329 pubmed publisher
Lai Y, Choi U, Leitz J, Rhee H, Lee C, Altas B, et al. Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. Neuron. 2017;95:591-607.e10 pubmed publisher
Acuna C, Liu X, Sudhof T. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 2016;91:792-807 pubmed publisher
Tang A, Chen H, Li T, Metzbower S, MacGillavry H, Blanpied T. A trans-synaptic nanocolumn aligns neurotransmitter release to receptors. Nature. 2016;536:210-4 pubmed
Farina M, van de Bospoort R, He E, Persoon C, van Weering J, Broeke J, et al. CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons. elife. 2015;4: pubmed publisher
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
Mendoza Schulz A, Jing Z, Sánchez Caro J, Wetzel F, Dresbach T, Strenzke N, et al. Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse. EMBO J. 2014;33:512-27 pubmed publisher
Ferrero J, Alvarez A, Ramírez Franco J, Godino M, Bartolomé Martín D, Aguado C, et al. ?-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1? interaction to potentiate glutamate release at cerebrocortical nerve terminals. J Biol Chem. 2013;288:31370-85 pubmed publisher
Chen Z, Cooper B, Kalla S, Varoqueaux F, Young S. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci. 2013;33:8336-51 pubmed publisher
Dudenhöffer Pfeifer M, Schirra C, Pattu V, Halimani M, Maier Peuschel M, Marshall M, et al. Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes. Traffic. 2013;14:798-809 pubmed publisher
Lanore F, Labrousse V, Szabo Z, Normand E, Blanchet C, Mulle C. Deficits in morphofunctional maturation of hippocampal mossy fiber synapses in a mouse model of intellectual disability. J Neurosci. 2012;32:17882-93 pubmed publisher
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T. Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission. Eur J Neurosci. 2012;36:3005-20 pubmed publisher
Bello O, Zanetti M, Mayorga L, Michaut M. RIM, Munc13, and Rab3A interplay in acrosomal exocytosis. Exp Cell Res. 2012;318:478-88 pubmed publisher
Martín R, Bartolomé Martín D, Torres M, Sánchez Prieto J. Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals. J Neurochem. 2011;116:476-85 pubmed publisher
Lanore F, Blanchet C, Fejtova A, Pinheiro P, Richter K, Balschun D, et al. Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon. J Physiol. 2010;588:2133-45 pubmed publisher
Jiang X, Litkowski P, Taylor A, Lin Y, Snider B, Moulder K. A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing. J Neurosci. 2010;30:1798-809 pubmed publisher
Fejtova A, Davydova D, Bischof F, Lazarevic V, Altrock W, Romorini S, et al. Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. J Cell Biol. 2009;185:341-55 pubmed publisher
product information
Company Name :
Synaptic Systems
Cat. Nr. :
126 103
Antigen :
Munc 13-1
Synonyms :
Munc 13-1, Munc 13-2, Munc 13-3, Munc13
Host Species :
rabbit
Tpye :
polyclonal
Form :
affinity purified
Immunogen :
Recombinant protein corresponding to AA 3 to 317 from rat Munc13-1 (UniProt Id: Q62768)
Reactivity :
human, rat, mouse, zebrafish
WB :
y
IP :
y
ICC :
y
IHC :
y
IHC P :
?
EM :
y
ELISA :
y
KO :
1
KD :
1
Quantity :
50 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany