product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Complexin 1/2
catalog :
122 002
quantity :
200 µl
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
African green monkey, human, mouse, rat, cow
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; loading ...; fig s6a
Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed publisher
  • western blot; rat; fig 1
Wang C, Wang Y, Hu M, Chai Z, Wu Q, Huang R, et al. Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep. 2016;17:47-63 pubmed publisher
  • western blot; human; fig 8
Bacaj T, Wu D, Burré J, Malenka R, Liu X, Sudhof T. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. PLoS Biol. 2015;13:e1002267 pubmed publisher
  • western blot; African green monkey; 1:3000; fig s8
Gu Q, Yu D, Hu Z, Liu X, Yang Y, Luo Y, et al. miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun. 2015;6:6789 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
Gispert S, Kurz A, Brehm N, Rau K, Walter M, Riess O, et al. Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology. Mol Neurobiol. 2015;52:57-63 pubmed publisher
  • western blot; mouse; fig 6
Lee S, Sharma M, S dhof T, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014;111:8973-8 pubmed publisher
Zurawski Z, Thompson Gray A, Brady L, Page B, Church E, Harris N, et al. Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Sci Signal. 2019;12: pubmed publisher
Alexander N, Rau A, Jimenez V, Daunais J, Grant K, McCool B. SNARE Complex-Associated Proteins in the Lateral Amygdala of Macaca mulatta Following Long-Term Ethanol Drinking. Alcohol Clin Exp Res. 2018;42:1661-1673 pubmed publisher
Mannironi C, Biundo A, Rajendran S, De Vito F, Saba L, Caioli S, et al. miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala. Mol Neurobiol. 2018;55:3301-3315 pubmed publisher
Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H. Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse. J Neurosci. 2015;35:8272-90 pubmed publisher
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
Hu Z, Yu D, Gu Q, Yang Y, Tu K, Zhu J, et al. miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression. Nat Commun. 2014;5:3263 pubmed publisher
Kaeser Woo Y, Younts T, Yang X, Zhou P, Wu D, Castillo P, et al. Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. J Neurosci. 2013;33:9769-80 pubmed publisher
Lin M, Rohan J, Cai H, Reim K, Ko C, Chow R. Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J Physiol. 2013;591:2463-73 pubmed publisher
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Sudhof T. CSP? knockout causes neurodegeneration by impairing SNAP-25 function. EMBO J. 2012;31:829-41 pubmed publisher
Falkowski M, Thomas D, Groblewski G. Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini. J Biol Chem. 2010;285:35558-66 pubmed publisher
Xue M, Stradomska A, Chen H, Brose N, Zhang W, Rosenmund C, et al. Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci U S A. 2008;105:7875-80 pubmed publisher
Hirano A, Brandstätter J, Brecha N. Cellular distribution and subcellular localization of molecular components of vesicular transmitter release in horizontal cells of rabbit retina. J Comp Neurol. 2005;488:70-81 pubmed
Reim K, Wegmeyer H, Brandst tter J, Xue M, Rosenmund C, Dresbach T, et al. Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol. 2005;169:669-80 pubmed publisher
Reim K, Mansour M, Varoqueaux F, McMahon H, Sudhof T, Brose N, et al. Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell. 2001;104:71-81 pubmed
product information
Cat. Nr. :
122 002
Antigen :
Complexin 1/2
Synonyms :
Synaphin 1, Synaphin 2, CPX 1, CPX 2, Complexin 1, Complexin 2, Complexin I, Complexin II, CPX I, CPX II, 2
Host Species :
rabbit
Tpye :
polyclonal
Form :
antiserum 1
add. Info :
C-terminus
Immunogen :
Synthetic peptide corresponding to AA 122 to 134 from human Complexin2 (UniProt Id: Q6PUV4)
Reactivity :
human, rat, mouse, cow, electric ray, rabbit
WB :
y
IP :
y
ICC :
y
IHC :
y
IHC P :
y
KO :
1
Quantity :
200 µl
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany