product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
SV2 B
catalog :
119 102
quantity :
200 µl
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
human, mouse, rat, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 22
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:4000; loading ...; fig 2a
Hunter D, Manglapus M, Bachay G, Claudepierre T, Dolan M, Gesuelli K, et al. CNS synapses are stabilized trans-synaptically by laminins and laminin-interacting proteins. J Comp Neurol. 2017;: pubmed publisher
Fukusumi Y, Wakamatsu A, Takashima N, Hasegawa E, Miyauchi N, Tomita M, et al. SV2B is essential for the integrity of the glomerular filtration barrier. Lab Invest. 2015;95:534-45 pubmed publisher
Hartfield E, Yamasaki Mann M, Ribeiro Fernandes H, Vowles J, James W, Cowley S, et al. Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE. 2014;9:e87388 pubmed publisher
Biesemann C, Gr Nborg M, Luquet E, Wichert S, Bernard V, Bungers S, et al. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. EMBO J. 2014;33:157-70 pubmed publisher
Crèvecœur J, Foerch P, Doupagne M, Thielen C, Vandenplas C, Moonen G, et al. Expression of SV2 isoforms during rodent brain development. BMC Neurosci. 2013;14:87 pubmed publisher
Mahrhold S, Strotmeier J, Garcia Rodriguez C, Lou J, Marks J, Rummel A, et al. Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E. Biochem J. 2013;453:37-47 pubmed publisher
Crèvecoeur J, Kaminski R, Rogister B, Foerch P, Vandenplas C, Neveux M, et al. Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis. Neuropathol Appl Neurobiol. 2014;40:191-204 pubmed publisher
Couesnon A, Molgo J, Connan C, Popoff M. Preferential entry of botulinum neurotoxin A Hc domain through intestinal crypt cells and targeting to cholinergic neurons of the mouse intestine. PLoS Pathog. 2012;8:e1002583 pubmed publisher
Blum F, Chen C, Kroken A, Barbieri J. Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system. Infect Immun. 2012;80:1662-9 pubmed publisher
Bragina L, Fattorini G, Gioved S, Melone M, Bosco F, Benfenati F, et al. Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals. Front Cell Neurosci. 2011;5:32 pubmed publisher
Lazarevic V, Sch ne C, Heine M, Gundelfinger E, Fejtova A. Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. J Neurosci. 2011;31:10189-200 pubmed publisher
Yeh F, Dong M, Yao J, Tepp W, Lin G, Johnson E, et al. SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathog. 2010;6:e1001207 pubmed publisher
Boido D, Farisello P, Cesca F, Ferrea E, Valtorta F, Benfenati F, et al. Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam. Neuroscience. 2010;171:268-83 pubmed publisher
Rummel A, Häfner K, Mahrhold S, Darashchonak N, Holt M, Jahn R, et al. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor. J Neurochem. 2009;110:1942-54 pubmed publisher
Morgans C, Kensel Hammes P, Hurley J, Burton K, IDZERDA R, McKnight G, et al. Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. PLoS ONE. 2009;4:e5230 pubmed publisher
Couesnon A, Pereira Y, Popoff M. Receptor-mediated transcytosis of botulinum neurotoxin A through intestinal cell monolayers. Cell Microbiol. 2008;10:375-87 pubmed
Verderio C, Grumelli C, Raiteri L, Coco S, Paluzzi S, Caccin P, et al. Traffic of botulinum toxins A and E in excitatory and inhibitory neurons. Traffic. 2007;8:142-53 pubmed
Miyauchi N, Saito A, Karasawa T, Harita Y, Suzuki K, Koike H, et al. Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli. J Am Soc Nephrol. 2006;17:2748-59 pubmed
Schivell A, Mochida S, Kensel Hammes P, Custer K, Bajjalieh S. SV2A and SV2C contain a unique synaptotagmin-binding site. Mol Cell Neurosci. 2005;29:56-64 pubmed
Redecker P, Kreutz M, Bockmann J, Gundelfinger E, Boeckers T. Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. J Histochem Cytochem. 2003;51:809-19 pubmed publisher
von Kriegstein K, Schmitz F. The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina. Cell Tissue Res. 2003;311:159-73 pubmed publisher
Janz R, Sudhof T. SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family. Neuroscience. 1999;94:1279-90 pubmed
product information
Cat. Nr. :
119 102
Antigen :
SV2 B
Synonyms :
SV2 B
Host Species :
rabbit
Tpye :
polyclonal
Form :
antiserum
Immunogen :
Synthetic peptide corresponding to AA 2 to 17 from rat SV2B (UniProt Id: Q63564)
Reactivity :
human, rat, mouse, hamster, chicken
WB :
y
IP :
y
ICC :
y
IHC :
y
IHC P :
y
KO :
1
Quantity :
200 µl
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany