product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Munc18-1
catalog :
116 002
quantity :
200 µl
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
human, mouse, rat, cow, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; loading ...; fig s6a
Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed publisher
  • western blot; human
Inoue M, Hur J, Kihara T, Teranishi Y, Yamamoto N, Ishikawa T, et al. Human brain proteins showing neuron-specific interactions with γ-secretase. FEBS J. 2015;282:2587-99 pubmed publisher
Davenport E, Szulc B, Drew J, Taylor J, Morgan T, Higgs N, et al. Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition. Cell Rep. 2019;26:2037-2051.e6 pubmed publisher
Duan M, Yan M, Wang Q, Mao M, Su D, Sun L, et al. Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes. Cell Commun Signal. 2018;16:91 pubmed publisher
Daraio T, Valladolid Acebes I, Brismar K, Bark C. SNAP-25a and SNAP-25b differently mediate interactions with Munc18-1 and Gβγ subunits. Neurosci Lett. 2018;674:75-80 pubmed publisher
Orock A, Logan S, Deak F. Munc18-1 haploinsufficiency impairs learning and memory by reduced synaptic vesicular release in a model of Ohtahara syndrome. Mol Cell Neurosci. 2018;88:33-42 pubmed publisher
Salunkhe V, Ofori J, Gandasi N, Salö S, Hansson S, Andersson M, et al. MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles. Physiol Rep. 2017;5: pubmed publisher
Miyamoto H, Shimohata A, Abe M, Abe T, Mazaki E, Amano K, et al. Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency. Hum Mol Genet. 2017;26:4961-4974 pubmed publisher
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
Cijsouw T, Weber J, Broeke J, Broek J, Schut D, Kroon T, et al. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner. J Cell Biol. 2014;204:759-75 pubmed publisher
Spangler S, Schmitz S, Kevenaar J, de Graaff E, de Wit H, Demmers J, et al. Liprin-?2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. J Cell Biol. 2013;201:915-28 pubmed publisher
Rodr guez F, Zanetti M, Mayorga L, Tomes C. Munc18-1 controls SNARE protein complex assembly during human sperm acrosomal exocytosis. J Biol Chem. 2012;287:43825-39 pubmed publisher
Jorgacevski J, Potokar M, Grilc S, Kreft M, Liu W, Barclay J, et al. Munc18-1 tuning of vesicle merger and fusion pore properties. J Neurosci. 2011;31:9055-66 pubmed publisher
Hellwig S, Hack I, Kowalski J, Brunne B, Jarowyj J, Unger A, et al. Role for Reelin in neurotransmitter release. J Neurosci. 2011;31:2352-60 pubmed publisher
Ohno Y, Ishihara S, Terada R, Kikuta M, Sofue N, Kawai Y, et al. Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling. Biochem Biophys Res Commun. 2009;390:415-20 pubmed publisher
Malintan N, Nguyen T, Han L, Latham C, Osborne S, Wen P, et al. Abrogating Munc18-1-SNARE complex interaction has limited impact on exocytosis in PC12 cells. J Biol Chem. 2009;284:21637-46 pubmed publisher
Camoletto P, Vara H, Morando L, Connell E, Marletto F, Giustetto M, et al. Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18. PLoS ONE. 2009;4:e5310 pubmed publisher
Kwok M, Holopainen J, Molday L, Foster L, Molday R. Proteomics of photoreceptor outer segments identifies a subset of SNARE and Rab proteins implicated in membrane vesicle trafficking and fusion. Mol Cell Proteomics. 2008;7:1053-66 pubmed publisher
Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T. Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol. 2005;171:99-109 pubmed
Olsen O, Moore K, Fukata M, Kazuta T, Trinidad J, Kauer F, et al. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol. 2005;170:1127-34 pubmed
Kasai K, Ohara Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta T, et al. Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J Clin Invest. 2005;115:388-96 pubmed
Zhang Q, Pangrsic T, Kreft M, Krzan M, Li N, Sul J, et al. Fusion-related release of glutamate from astrocytes. J Biol Chem. 2004;279:12724-33 pubmed
Houng A, Polgar J, Reed G. Munc18-syntaxin complexes and exocytosis in human platelets. J Biol Chem. 2003;278:19627-33 pubmed
Varoqueaux F, Sigler A, Rhee J, Brose N, Enk C, Reim K, et al. Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A. 2002;99:9037-42 pubmed
Zhang W, Efanov A, Yang S, Fried G, Kolare S, Brown H, et al. Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta -cell. J Biol Chem. 2000;275:41521-7 pubmed
product information
Cat. Nr. :
116 002
Antigen :
Munc18-1
Synonyms :
rb-Sec1, n-Sec1, p67, stxbp2, stxbp1, Munc 18-1, Munc 18-2, Munc 18-3
Host Species :
rabbit
Tpye :
polyclonal
Form :
antiserum
Immunogen :
Synthetic peptide corresponding to AA 580 to 594 from rat Munc18-1 (UniProt Id: P61765)
Reactivity :
human, rat, mouse, cow
WB :
y
IP :
y
ICC :
y
IHC :
y
IHC P :
y
ELISA :
y
KD :
1
Quantity :
200 µl
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany