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company name :
Synaptic Systems
product type :
antibody
product name :
Syntaxin 1A
catalog :
110 111
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
78.3
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:10,000; loading ...; fig 3e
Frei J, Brandenburg C, Nestor J, Hodzic D, Plachez C, McNeill H, et al. Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism. Biol Open. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6a
Hamada N, Iwamoto I, Tabata H, Nagata K. MUNC18-1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development. Acta Neuropathol Commun. 2017;5:92 pubmed publisher
  • western blot; mouse; 1:1000; fig 3i
Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Daniel J, Cooper B, Palvimo J, Zhang F, Brose N, Tirard M. Analysis of SUMO1-conjugation at synapses. elife. 2017;6: pubmed publisher
  • immunoprecipitation; rat; fig 4a
  • western blot; rat; 1:2000; fig 3a
Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, et al. Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons. PLoS ONE. 2016;11:e0164544 pubmed publisher
  • western blot; rat; 1:250; fig 1
  • western blot; human; 1:100
Tao Cheng J, Pham A, Yang Y, Winters C, Gallant P, Reese T. Syntaxin 4 is concentrated on plasma membrane of astrocytes. Neuroscience. 2015;286:264-71 pubmed publisher
Duan M, Yan M, Wang Q, Mao M, Su D, Sun L, et al. Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes. Cell Commun Signal. 2018;16:91 pubmed publisher
Zheng Y, Shen W, Zhang J, Yang B, Liu Y, Qi H, et al. CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018;21:447-454 pubmed publisher
Sakamoto H, Ariyoshi T, Kimpara N, Sugao K, Taiko I, Takikawa K, et al. Synaptic weight set by Munc13-1 supramolecular assemblies. Nat Neurosci. 2018;21:41-49 pubmed publisher
Koo S, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, et al. Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission. Neuron. 2015;88:330-44 pubmed publisher
Ahmed S, Holt M, Riedel D, Jahn R. Small-scale isolation of synaptic vesicles from mammalian brain. Nat Protoc. 2013;8:998-1009 pubmed publisher
Araya Callis C, Hiemke C, Abumaria N, Flugge G. Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus. Psychopharmacology (Berl). 2012;224:209-22 pubmed publisher
Ribrault C, Reingruber J, Petkovic M, Galli T, Ziv N, Holcman D, et al. Syntaxin1A lateral diffusion reveals transient and local SNARE interactions. J Neurosci. 2011;31:17590-602 pubmed publisher
Lazarevic V, Sch ne C, Heine M, Gundelfinger E, Fejtova A. Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. J Neurosci. 2011;31:10189-200 pubmed publisher
Barth J, Zimmermann H, Volknandt W. SV31 is a Zn2+-binding synaptic vesicle protein. J Neurochem. 2011;118:558-70 pubmed publisher
Jiang X, Litkowski P, Taylor A, Lin Y, Snider B, Moulder K. A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing. J Neurosci. 2010;30:1798-809 pubmed publisher
Barszczewski M, Chua J, Stein A, Winter U, Heintzmann R, Zilly F, et al. A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion. Mol Biol Cell. 2008;19:776-84 pubmed
Lam A, Tryoen Toth P, Tsai B, Vitale N, Stuenkel E. SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions. Mol Biol Cell. 2008;19:485-97 pubmed
Bilan F, Thoreau V, Nacfer M, Derand R, Norez C, Cantereau A, et al. Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity. J Cell Sci. 2004;117:1923-35 pubmed
Hatsuzawa K, Lang T, Fasshauer D, Bruns D, Jahn R. The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis. J Biol Chem. 2003;278:31159-66 pubmed
Ganeshan R, Di A, Nelson D, Quick M, Kirk K. The interaction between syntaxin 1A and cystic fibrosis transmembrane conductance regulator Cl- channels is mechanistically distinct from syntaxin 1A-SNARE interactions. J Biol Chem. 2003;278:2876-85 pubmed
Varoqueaux F, Sigler A, Rhee J, Brose N, Enk C, Reim K, et al. Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A. 2002;99:9037-42 pubmed
product information
Cat. Nr. :
110 111
Antigen :
Syntaxin 1A
Synonyms :
p35, Syntaxin 1A, Syntaxin 1B, stx 1, stx 1A, stx 1B, stx1, p35A
Host Species :
mouse
Tpye :
monoclonal
Form :
purified IgG
Cell Line :
78.3
Subtype :
IgG2a
Immunogen :
Recombinant protein corresponding to AA 1 to 262 from rat Syntaxin1A (UniProt Id: P32851)
Reactivity :
human, rat, mouse, mammals, chicken
WB :
WB
IP :
IP
ICC :
ICC
IHC P :
IHC-P
EM :
EM
KO :
yes
Quantity :
100 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany