product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Syntaxin 1
catalog :
110 011
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
78.2
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 36
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; rat; loading ...
Ivanova D, Dobson K, Gajbhiye A, Davenport E, Hacker D, Ultanir S, et al. Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes. Sci Adv. 2021;7: pubmed publisher
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 1b
Ishii C, Shibano N, Yamazaki M, Arima T, Kato Y, Ishii Y, et al. CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning. Sci Rep. 2021;11:8656 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1
Raja M, Preobraschenski J, Del Olmo Cabrera S, Martínez Turrillas R, Jahn R, Pérez Otaño I, et al. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. elife. 2019;8: pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 9
  • western blot; mouse; loading ...; fig 4
Vazquez Cintron E, Beske P, Tenezaca L, Tran B, Oyler J, Glotfelty E, et al. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017;7:42923 pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 5a
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  • western blot; mouse; 1:1000; fig 3a
Sambri I, D Alessio R, Ezhova Y, Giuliano T, Sorrentino N, Cacace V, et al. Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases. EMBO Mol Med. 2017;9:112-132 pubmed publisher
  • immunocytochemistry; mouse; fig 6a
Toft Bertelsen T, Ziomkiewicz I, Houy S, Pinheiro P, Sørensen J. Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters. Mol Biol Cell. 2016;27:3329-3341 pubmed
  • western blot; human; 1:10,000; fig 6B
Benítez B, Cairns N, Schmidt R, Morris J, Norton J, Cruchaga C, et al. Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss. Acta Neuropathol Commun. 2015;3:73 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 4
  • immunohistochemistry; rat; 1:100; fig 4
Tao Cheng J, Pham A, Yang Y, Winters C, Gallant P, Reese T. Syntaxin 4 is concentrated on plasma membrane of astrocytes. Neuroscience. 2015;286:264-71 pubmed publisher
Pellett S, Tepp W, Johnson E. Botulinum neurotoxins A, B, C, E, and F preferentially enter cultured human motor neurons compared to other cultured human neuronal populations. FEBS Lett. 2019;593:2675-2685 pubmed publisher
Coy Vergara J, Rivera Monroy J, Urlaub H, Lenz C, Schwappach B. A trap mutant reveals the physiological client spectrum of TRC40. J Cell Sci. 2019;: pubmed publisher
Maidorn M, Olichon A, Rizzoli S, Opazo F. Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons. MAbs. 2019;11:305-321 pubmed publisher
Bello O, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski K, et al. Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis. Proc Natl Acad Sci U S A. 2018;115:E7624-E7631 pubmed publisher
Lopez J, Noori T, Minson A, Li Jovanoska L, Thia K, Hildebrand M, et al. Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing. Front Immunol. 2018;9:529 pubmed publisher
Zhang S, Lebreton F, Mansfield M, Miyashita S, Zhang J, Schwartzman J, et al. Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host Microbe. 2018;23:169-176.e6 pubmed publisher
Liu X, Li J, Guo C, Wang H, Sun Y, Wang H, et al. Olanzapine Reverses MK-801-Induced Cognitive Deficits and Region-Specific Alterations of NMDA Receptor Subunits. Front Behav Neurosci. 2017;11:260 pubmed publisher
Houy S, Groffen A, Ziomkiewicz I, Verhage M, Pinheiro P, Sørensen J. Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs. elife. 2017;6: pubmed publisher
Sakamoto H, Ariyoshi T, Kimpara N, Sugao K, Taiko I, Takikawa K, et al. Synaptic weight set by Munc13-1 supramolecular assemblies. Nat Neurosci. 2018;21:41-49 pubmed publisher
Richter K, Revelo N, Seitz K, Helm M, Sarkar D, Saleeb R, et al. Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy. EMBO J. 2018;37:139-159 pubmed publisher
Nakaya N, Sultana A, Tomarev S. Impaired AMPA receptor trafficking by a double knockout of zebrafish olfactomedin1a/b. J Neurochem. 2017;143:635-644 pubmed publisher
Woolger N, Bournazos A, Sophocleous R, Evesson F, Lek A, Driemer B, et al. Limited proteolysis as a tool to probe the tertiary conformation of dysferlin and structural consequences of patient missense variant L344P. J Biol Chem. 2017;292:18577-18591 pubmed publisher
Lai Y, Choi U, Leitz J, Rhee H, Lee C, Altas B, et al. Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. Neuron. 2017;95:591-607.e10 pubmed publisher
Grassi D, Plonka F, Oksdath M, Guil A, Sosa L, Quiroga S. Selected SNARE proteins are essential for the polarized membrane insertion of igf-1 receptor and the regulation of initial axonal outgrowth in neurons. Cell Discov. 2015;1:15023 pubmed publisher
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes D, Anane D, et al. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Nat Commun. 2015;6:8302 pubmed publisher
Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H. Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse. J Neurosci. 2015;35:8272-90 pubmed publisher
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
Revelo N, Kamin D, Truckenbrodt S, Wong A, Reuter Jessen K, Reisinger E, et al. A new probe for super-resolution imaging of membranes elucidates trafficking pathways. J Cell Biol. 2014;205:591-606 pubmed publisher
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T. Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission. Eur J Neurosci. 2012;36:3005-20 pubmed publisher
Kaeser Woo Y, Yang X, Sudhof T. C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis. J Neurosci. 2012;32:2877-85 pubmed publisher
Bartolomé Martín D, Ramírez Franco J, Castro E, Sánchez Prieto J, Torres M. Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages. J Cell Sci. 2012;125:422-34 pubmed publisher
Treppmann P, Brunk I, Afube T, Richter K, Ahnert Hilger G. Neurotoxic phospholipases directly affect synaptic vesicle function. J Neurochem. 2011;117:757-64 pubmed publisher
Jockusch W, Speidel D, Sigler A, S rensen J, Varoqueaux F, Rhee J, et al. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell. 2007;131:796-808 pubmed publisher
Smith R, Klein P, Koc Schmitz Y, Waldvogel H, Faull R, Brundin P, et al. Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. J Neurochem. 2007;103:115-23 pubmed
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. J Neurochem. 2005;95:1732-45 pubmed
Reim K, Wegmeyer H, Brandst tter J, Xue M, Rosenmund C, Dresbach T, et al. Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol. 2005;169:669-80 pubmed publisher
Lazzell D, Belizaire R, Thakur P, Sherry D, Janz R. SV2B regulates synaptotagmin 1 by direct interaction. J Biol Chem. 2004;279:52124-31 pubmed publisher
product information
Cat. Nr. :
110 011
Antigen :
Syntaxin 1
Synonyms :
p35, Syntaxin 1A, Syntaxin 1B, stx 1, stx 1A, stx 1B, stx1, p35A
Host Species :
mouse
Tpye :
monoclonal
Form :
purified IgG
Cell Line :
78.2
Subtype :
IgG1
Immunogen :
Recombinant protein corresponding to AA 1 to 262 from rat Syntaxin1A (UniProt Id: P32851)
Reactivity :
human, rat, mouse, mammals, chicken, zebrafish, leech
WB :
WB
IP :
IP
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
EM :
EM
ELISA :
ELISA
Quantity :
100 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany