product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Rab3a
catalog :
107 111
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
42.2
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 1b, 1f, s1a
Azarnia Tehran D, Kochlamazashvili G, Pampaloni N, Sposini S, Shergill J, Lehmann M, et al. Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity. Sci Adv. 2022;8:eabl5032 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 1b
Arias Hervert E, Xu N, Njus M, Murphy G, Hou Y, Williams J, et al. Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission. Physiol Rep. 2020;8:e14428 pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 5a
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  • western blot; rat; 1:2000
Marrocco J, Reynaert M, Gatta E, Gabriel C, Moca r E, Di Prisco S, et al. The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders. J Neurosci. 2014;34:2015-24 pubmed publisher
Peggion C, Stella R, Chemello F, Massimino M, Arrigoni G, Cagnin S, et al. The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis. Mol Neurobiol. 2019;56:3420-3436 pubmed publisher
Alexander N, Rau A, Jimenez V, Daunais J, Grant K, McCool B. SNARE Complex-Associated Proteins in the Lateral Amygdala of Macaca mulatta Following Long-Term Ethanol Drinking. Alcohol Clin Exp Res. 2018;42:1661-1673 pubmed publisher
Morley Fletcher S, Zuena A, Mairesse J, Gatta E, Van Camp G, Bouwalerh H, et al. The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats. Neuropharmacology. 2018;135:284-296 pubmed publisher
Caswell P, Dickens M. JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells. Mol Cell Biochem. 2018;444:1-13 pubmed publisher
Close W, Bhandari A, Hojeij M, Pellett P. Generation of a novel human cytomegalovirus bacterial artificial chromosome tailored for transduction of exogenous sequences. Virus Res. 2017;242:66-78 pubmed publisher
Gioia D, Alexander N, McCool B. Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2. Front Neurosci. 2017;11:424 pubmed publisher
Ullrich M, Weber M, Post A, Popp S, Grein J, Zechner M, et al. OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency. Mol Psychiatry. 2018;23:444-458 pubmed publisher
Rutkowska Wlodarczyk I, Aller M, Valbuena S, Bologna J, Prézeau L, Lerma J. A proteomic analysis reveals the interaction of GluK1 ionotropic kainate receptor subunits with Go proteins. J Neurosci. 2015;35:5171-9 pubmed publisher
Shinoda Y, Ahmed S, Ramachandran B, Bharat V, Brockelt D, Altas B, et al. BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons. Front Synaptic Neurosci. 2014;6:27 pubmed publisher
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
Bonnet S, Akad D, Samaddar T, Liu Y, Huang X, Dong Y, et al. Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102. J Neurosci. 2013;33:13398-409 pubmed publisher
Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Kiran Akula A, Urlaub H, et al. Mover is a homomeric phospho-protein present on synaptic vesicles. PLoS ONE. 2013;8:e63474 pubmed publisher
Kempf C, Staudt T, Bingen P, Horstmann H, Engelhardt J, Hell S, et al. Tissue multicolor STED nanoscopy of presynaptic proteins in the calyx of Held. PLoS ONE. 2013;8:e62893 pubmed publisher
Ahmed S, Holt M, Riedel D, Jahn R. Small-scale isolation of synaptic vesicles from mammalian brain. Nat Protoc. 2013;8:998-1009 pubmed publisher
Marrocco J, Mairesse J, Ngomba R, Silletti V, Van Camp G, Bouwalerh H, et al. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. J Neurosci. 2012;32:17143-54 pubmed publisher
Hruskova B, Trojanova J, Kulik A, Kralikova M, Pysanenko K, Bures Z, et al. Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse. J Neurosci. 2012;32:17012-24 pubmed publisher
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T. Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission. Eur J Neurosci. 2012;36:3005-20 pubmed publisher
Bragina L, Fattorini G, Gioved S, Melone M, Bosco F, Benfenati F, et al. Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals. Front Cell Neurosci. 2011;5:32 pubmed publisher
Wang X, Wang Q, Yang S, Bucan M, Rich M, Engisch K. Impaired activity-dependent plasticity of quantal amplitude at the neuromuscular junction of Rab3A deletion and Rab3A earlybird mutant mice. J Neurosci. 2011;31:3580-8 pubmed publisher
Wollert T, Patel A, Lee Y, Provance D, Vought V, Cosgrove M, et al. Myosin5a tail associates directly with Rab3A-containing compartments in neurons. J Biol Chem. 2011;286:14352-61 pubmed publisher
Pavlos N, Gr Nborg M, Riedel D, Chua J, Boyken J, Kloepper T, et al. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci. 2010;30:13441-53 pubmed publisher
Smith R, Klein P, Koc Schmitz Y, Waldvogel H, Faull R, Brundin P, et al. Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. J Neurochem. 2007;103:115-23 pubmed
Yang S, Farias M, Kapfhamer D, Tobias J, Grant G, Abel T, et al. Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse. Genes Brain Behav. 2007;6:77-96 pubmed
Yelamanchili S, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert Hilger G. Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. J Biol Chem. 2006;281:15671-9 pubmed
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. J Neurochem. 2005;95:1732-45 pubmed
Kapfhamer D, Valladares O, Sun Y, Nolan P, Rux J, Arnold S, et al. Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nat Genet. 2002;32:290-5 pubmed
Oorschot V, de Wit H, Annaert W, Klumperman J. A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation. J Histochem Cytochem. 2002;50:1067-80 pubmed publisher
Chamberlain L, Burgoyne R, Gould G. SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Proc Natl Acad Sci U S A. 2001;98:5619-24 pubmed publisher
Abeliovich A, Schmitz Y, Farinas I, Choi Lundberg D, Ho W, Castillo P, et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000;25:239-52 pubmed
Schlüter O, Schnell E, Verhage M, Tzonopoulos T, Nicoll R, Janz R, et al. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. J Neurosci. 1999;19:5834-46 pubmed
product information
Cat. Nr. :
107 111
Antigen :
Rab3a
Synonyms :
rab 3a
Host Species :
mouse
Tpye :
monoclonal
Form :
purified IgG
Cell Line :
42.2
Subtype :
IgG1
Immunogen :
Recombinant protein corresponding to AA 1 to 220 from rat Rab3a (UniProt Id: P63012)
Reactivity :
human, rat, mouse, mammals
WB :
WB
IP :
IP
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
EM :
EM
ELISA :
ELISA
KO :
yes
Quantity :
100 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany