This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Synaptic Systems
product type :
antibody
product name :
Synapsin 1
catalog :
106 001
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
46.1
reactivity :
human, mouse, rat, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 50
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2a
Daniel J, Cooper B, Palvimo J, Zhang F, Brose N, Tirard M. Analysis of SUMO1-conjugation at synapses. elife. 2017;6: pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100
  • immunocytochemistry; human; 1:100; fig 3e
Quadrato G, Nguyen T, Macosko E, Sherwood J, Min Yang S, Berger D, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545:48-53 pubmed publisher
  • western blot; human; 1:2000; fig 1h
Sellgren C, Sheridan S, Gracias J, Xuan D, Fu T, Perlis R. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol Psychiatry. 2017;22:170-177 pubmed publisher
  • immunocytochemistry; human; 1:5000; fig 3
Xue Y, Qian H, Hu J, Zhou B, Zhou Y, Hu X, et al. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nat Neurosci. 2016;19:807-15 pubmed publisher
  • immunocytochemistry; human; fig 2
Kim E, Jeon C, Lee S, Hwang I, Chung T. Robust Type-specific Hemisynapses Induced by Artificial Dendrites. Sci Rep. 2016;6:24210 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 1
Ukken F, Bruckner J, Weir K, Hope S, Sison S, Birschbach R, et al. BAR-SH3 sorting nexins are conserved interacting proteins of Nervous wreck that organize synapses and promote neurotransmission. J Cell Sci. 2016;129:166-77 pubmed publisher
  • immunocytochemistry; mouse; fig 7
Bender J, Engeholm M, Ederer M, Breu J, Møller T, Michalakis S, et al. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PLoS ONE. 2015;10:e0136768 pubmed publisher
  • western blot; human
Cuesto G, Jordán Álvarez S, Enriquez Barreto L, Ferrús A, Morales M, Acebes A. GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS ONE. 2015;10:e0118475 pubmed publisher
  • western blot; human; fig 3
Bavamian S, Mellios N, Lalonde J, Fass D, Wang J, Sheridan S, et al. Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder. Mol Psychiatry. 2015;20:573-84 pubmed publisher
  • western blot; mouse
Verstegen A, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, et al. Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses. J Neurosci. 2014;34:7266-80 pubmed publisher
Kyrargyri V, Madry C, Rifat A, Arancibia Carcamo I, Jones S, Chan V, et al. P2Y13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release. Glia. 2019;: pubmed publisher
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, et al. SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring. Neuron. 2019;: pubmed publisher
Chanda S, Ang C, Lee Q, Ghebrial M, Haag D, Shibuya Y, et al. Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity. Cell Stem Cell. 2019;: pubmed publisher
Brockhaus J, Brüggen B, Missler M. Imaging and Analysis of Presynaptic Calcium Influx in Cultured Neurons Using synGCaMP6f. Front Synaptic Neurosci. 2019;11:12 pubmed publisher
Gerth F, Jäpel M, Sticht J, Kuropka B, Schmitt X, Driller J, et al. Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain. Structure. 2019;27:977-987.e5 pubmed publisher
Neumann J, Dash Wagh S, Jack A, Räk A, Jüngling K, Hamad M, et al. The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines. PLoS ONE. 2019;14:e0211151 pubmed publisher
Schoderboeck L, Wicky H, Abraham W, Hughes S. Genetic targeting and chemogenetic inhibition of new born neurons. Hum Gene Ther Methods. 2018;: pubmed publisher
Yamamoto H, Moriya S, Ide K, Hayakawa T, Akima H, Sato S, et al. Impact of modular organization on dynamical richness in cortical networks. Sci Adv. 2018;4:eaau4914 pubmed publisher
van der Heijden M, Zoghbi H. Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. elife. 2018;7: pubmed publisher
Birnbaum J, Wanner D, Gietl A, Saake A, Kundig T, Hock C, et al. Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients. Stem Cell Res. 2018;27:121-130 pubmed publisher
Riemann D, Wallrafen R, Dresbach T. The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein. Sci Rep. 2017;7:15791 pubmed publisher
Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao P, et al. Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects. J Neurosci. 2017;37:8655-8666 pubmed publisher
Dunn C, Sarkar P, Bailey E, Farris S, Zhao M, Ward J, et al. Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes. Eneuro. 2017;4: pubmed publisher
Lin Q, Ponnusamy R, Widagdo J, Choi J, Ge W, Probst C, et al. MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proc Natl Acad Sci U S A. 2017;114:9188-9193 pubmed publisher
Chanda S, Hale W, Zhang B, Wernig M, Sudhof T. Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties. J Neurosci. 2017;37:6816-6836 pubmed publisher
Valtcheva M, Copits B, Davidson S, Sheahan T, Pullen M, McCall J, et al. Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures. Nat Protoc. 2016;11:1877-88 pubmed publisher
Acuna C, Liu X, Sudhof T. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 2016;91:792-807 pubmed publisher
Paniagua A, Herranz Martin S, Jimeno D, Jimeno Á, López Benito S, Carlos Arévalo J, et al. CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium. Sci Rep. 2015;5:14504 pubmed publisher
Liu C, Bickford L, Held R, Nyitrai H, Südhof T, Kaeser P. The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons. J Neurosci. 2014;34:12289-303 pubmed publisher
Andreska T, Aufmkolk S, Sauer M, Blum R. High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons. Front Cell Neurosci. 2014;8:107 pubmed publisher
Toader O, Forte N, Orlando M, Ferrea E, Raimondi A, Baldelli P, et al. Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures. Front Cell Neurosci. 2013;7:138 pubmed publisher
Saul A, Sprenger F, Bayer T, Wirths O. Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease. Neurobiol Aging. 2013;34:2564-73 pubmed publisher
Kempf C, Staudt T, Bingen P, Horstmann H, Engelhardt J, Hell S, et al. Tissue multicolor STED nanoscopy of presynaptic proteins in the calyx of Held. PLoS ONE. 2013;8:e62893 pubmed publisher
Li D, Hérault K, Silm K, Evrard A, Wojcik S, Oheim M, et al. Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes. J Neurosci. 2013;33:4434-55 pubmed publisher
Zhao J, He H, Zhou K, Ren Y, Shi Z, Wu Z, et al. Neuronal transcription factors induce conversion of human glioma cells to neurons and inhibit tumorigenesis. PLoS ONE. 2012;7:e41506 pubmed publisher
Bartolomé Martín D, Ramírez Franco J, Castro E, Sánchez Prieto J, Torres M. Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages. J Cell Sci. 2012;125:422-34 pubmed publisher
Zhang Z, Cai Y, Zou F, Bie B, Pan Z. Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med. 2011;17:1448-55 pubmed publisher
Waites C, Leal Ortiz S, Andlauer T, Sigrist S, Garner C. Piccolo regulates the dynamic assembly of presynaptic F-actin. J Neurosci. 2011;31:14250-63 pubmed publisher
Chen J, Billings S, Nishimune H. Calcium channels link the muscle-derived synapse organizer laminin ?2 to Bassoon and CAST/Erc2 to organize presynaptic active zones. J Neurosci. 2011;31:512-25 pubmed publisher
Heinrich C, Blum R, Gasc n S, Masserdotti G, Tripathi P, S nchez R, et al. Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol. 2010;8:e1000373 pubmed publisher
Revest J, Kaouane N, Mondin M, le Roux A, Roug Pont F, Vall e M, et al. The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib. Mol Psychiatry. 2010;15:1125, 1140-51 pubmed publisher
Podrygajlo G, Tegenge M, Gierse A, Paquet Durand F, Tan S, Bicker G, et al. Cellular phenotypes of human model neurons (NT2) after differentiation in aggregate culture. Cell Tissue Res. 2009;336:439-52 pubmed publisher
Pan P, Tian J, Sheng Z. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron. 2009;61:412-24 pubmed publisher
Fox M, Sanes J. Synaptotagmin I and II are present in distinct subsets of central synapses. J Comp Neurol. 2007;503:280-96 pubmed
Yelamanchili S, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert Hilger G. Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. J Biol Chem. 2006;281:15671-9 pubmed
Thomas C, Miller A, Westbrook G. Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. J Neurophysiol. 2006;95:1727-34 pubmed
Talbot K, Eidem W, Tinsley C, Benson M, Thompson E, Smith R, et al. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J Clin Invest. 2004;113:1353-63 pubmed
Obermair G, Szabo Z, Bourinet E, Flucher B. Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons. Eur J Neurosci. 2004;19:2109-22 pubmed
Nowicka D, Liguz Lecznar M, Skangiel Kramska J. A surface antigen delineating a subset of neurons in the primary somatosensory cortex of the mouse. Acta Neurobiol Exp (Wars). 2003;63:185-95 pubmed
Abeliovich A, Schmitz Y, Farinas I, Choi Lundberg D, Ho W, Castillo P, et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000;25:239-52 pubmed
product information
Company Name :
Synaptic Systems
Cat. Nr. :
106 001
Antigen :
Synapsin 1
Synonyms :
Syn1
Host Species :
mouse
Tpye :
monoclonal
Form :
ascites
Cell Line :
46.1
Subtype :
IgG1
Immunogen :
Recombinant protein corresponding to AA 1 to 704 from rat Synapsin1 (UniProt Id: P09951)
Reactivity :
human, rat, mouse, mammals, zebrafish, chicken, other vertebrates
WB :
y
IP :
y
ICC :
y
IHC :
y
IHC P :
y
EM :
y
ELISA :
y
KO :
1
Quantity :
100 µl
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany