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company name :
Synaptic Systems
product type :
antibody
product name :
Synaptotagmin 7
catalog :
105 173
quantity :
50 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation, immunohistochemistry knockout validation, immunocytochemistry knockout validation
more info or order :
citations: 22
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; rat; 1:200; loading ...; fig 8a
  • western blot knockout validation; rat; 1:200; loading ...; fig 8b
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:200; fig s2
Jackman S, Turecek J, Belinsky J, Regehr W. The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature. 2016;529:88-91 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 1a
Sung B, Ketova T, Hoshino D, Zijlstra A, Weaver A. Directional cell movement through tissues is controlled by exosome secretion. Nat Commun. 2015;6:7164 pubmed publisher
Zhang J, He J, Johnson J, Napolitano G, Ramadass M, Rahman F, et al. Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Autophagy. 2019;:1-19 pubmed publisher
Zurawski Z, Thompson Gray A, Brady L, Page B, Church E, Harris N, et al. Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Sci Signal. 2019;12: pubmed publisher
Bello O, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski K, et al. Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis. Proc Natl Acad Sci U S A. 2018;115:E7624-E7631 pubmed publisher
Bendahmane M, Bohannon K, Bradberry M, Rao T, Schmidtke M, Abbineni P, et al. The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion. Mol Biol Cell. 2018;29:773-880 pubmed publisher
Richter K, Revelo N, Seitz K, Helm M, Sarkar D, Saleeb R, et al. Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy. EMBO J. 2018;37:139-159 pubmed publisher
Houy S, Groffen A, Ziomkiewicz I, Verhage M, Pinheiro P, Sørensen J. Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs. elife. 2017;6: pubmed publisher
Trajkovic K, Jeong H, Krainc D. Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway. J Neurosci. 2017;37:9000-9012 pubmed publisher
Tratnjek L, Zivin M, Glavan G. Synaptotagmin 7 and SYNCRIP proteins are ubiquitously expressed in the rat brain and co-localize in Purkinje neurons. J Chem Neuroanat. 2017;79:12-21 pubmed publisher
Dolai S, Xie L, Zhu D, Liang T, Qin T, Xie H, et al. Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet ?-Cells. Diabetes. 2016;65:1962-76 pubmed publisher
Sreetama S, Takano T, Nedergaard M, Simon S, Jaiswal J. Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis. Cell Death Differ. 2016;23:596-607 pubmed publisher
Roper L, Briguglio J, Evans C, Jackson M, Chapman E. Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9. Nat Commun. 2015;6:8645 pubmed publisher
Kim S, Kim Y, Park W, Kim H, Jung S, Woo S, et al. Characterisation of insulin-producing cells differentiated from tonsil derived mesenchymal stem cells. Differentiation. 2015;90:27-39 pubmed publisher
Rao T, Passmore D, Peleman A, Das M, Chapman E, Anantharam A. Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules. Mol Biol Cell. 2014;25:2416-27 pubmed publisher
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
Andersson S, Olsson A, Esguerra J, Heimann E, Ladenvall C, Edlund A, et al. Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes. Mol Cell Endocrinol. 2012;364:36-45 pubmed publisher
Mendez J, Bourque M, Fasano C, Kortleven C, Trudeau L. Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels. J Biol Chem. 2011;286:23928-37 pubmed publisher
Gustavsson N, Wang Y, Kang Y, Seah T, Chua S, Radda G, et al. Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion in mice. Diabetologia. 2011;54:1824-30 pubmed publisher
Abe N, Almenar Queralt A, Lillo C, Shen Z, Lozach J, Briggs S, et al. Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem. 2009;284:34628-39 pubmed publisher
Gustavsson N, Wei S, Hoang D, Lao Y, Zhang Q, Radda G, et al. Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. J Physiol. 2009;587:1169-78 pubmed publisher
product information
Company Name :
Synaptic Systems
Cat. Nr. :
105 173
Antigen :
Synaptotagmin 7
Synonyms :
Synaptotagmin VII, Syt7
Host Species :
rabbit
Tpye :
polyclonal
Form :
affinity purified
Immunogen :
Recombinant protein corresponding to AA 46 to 133 from rat Synaptotagmin7 (UniProt Id: Q62747)
Reactivity :
human, rat, mouse
WB :
y
IP :
?
ICC :
y
IHC :
y
IHC P :
?
KO :
1
Quantity :
50 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany