product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Synaptobrevin 2
catalog :
104 211
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
69.1
reactivity :
human, mouse, rat, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay, immunocytochemistry knockout validation
more info or order :
citations: 176
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; mouse; 1:1000; loading ...; fig 1s1c
Dhara M, Mantero Martinez M, Makke M, Schwarz Y, Mohrmann R, Bruns D. Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release. elife. 2020;9: pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; fig 1p
Haytural H, Jordà Siquier T, Winblad B, Mulle C, Tjernberg L, Granholm A, et al. Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease. Brain Commun. 2021;3:fcab079 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 1b
Ishii C, Shibano N, Yamazaki M, Arima T, Kato Y, Ishii Y, et al. CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning. Sci Rep. 2021;11:8656 pubmed publisher
  • immunohistochemistry; human; 1:500
Inak G, Rybak Wolf A, Lisowski P, Pentimalli T, Jüttner R, Glažar P, et al. Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome. Nat Commun. 2021;12:1929 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 6d
Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, et al. Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice. Nat Commun. 2021;12:1848 pubmed publisher
  • western blot; rat; loading ...; fig 5s1
Kreutzberger A, Kiessling V, Doyle C, Schenk N, Upchurch C, Elmer Dixon M, et al. Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2. elife. 2020;9: pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig s2-1e
Huson V, Meijer M, Dekker R, ter Veer M, Ruiter M, van Weering J, et al. Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Sclip A, Sudhof T. LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2i
Park H, Kim T, Kim J, Yamamoto Y, Tanaka Yamamoto K. Inputs from Sequentially Developed Parallel Fibers Are Required for Cerebellar Organization. Cell Rep. 2019;28:2939-2954.e5 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...; fig 5b
Yagensky O, Kohansal Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, et al. Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. elife. 2019;8: pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 3e
Sun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisher
  • proximity ligation assay; mouse; 1:250; loading ...; fig s14e
Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, et al. LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Mol Syst Biol. 2018;14:e8071 pubmed publisher
  • western blot; mouse; fig 2e
Biggi S, Buccarello L, Sclip A, Lippiello P, Tonna N, Rumio C, et al. Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase. Neural Plast. 2017;2017:6468356 pubmed publisher
  • immunocytochemistry; bovine; fig 1b
  • western blot; bovine; fig s1
Gümürdü A, Yildiz R, Eren E, Karakülah G, Unver T, Genc S, et al. MicroRNA exocytosis by large dense-core vesicle fusion. Sci Rep. 2017;7:45661 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 7e
Santos T, Wierda K, Broeke J, Toonen R, Verhage M. Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25. J Neurosci. 2017;37:4525-4539 pubmed publisher
  • western blot; mouse; loading ...; tbl 1
Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed publisher
  • western blot; mouse; loading ...; fig 4
  • immunocytochemistry; rat; loading ...; fig 8b
Vazquez Cintron E, Beske P, Tenezaca L, Tran B, Oyler J, Glotfelty E, et al. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017;7:42923 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3a
  • western blot; mouse; 1:5000; loading ...; fig 1a
Horvath P, Kavalali E, Monteggia L. CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neurons. J Neurosci Methods. 2017;278:57-64 pubmed publisher
  • immunocytochemistry; rat; 1:4000; loading ...; fig 5c
  • western blot; rat; 1:4000; loading ...; fig 5a
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  • immunocytochemistry; mouse; fig 4b
Shang S, Zhu F, Liu B, Chai Z, Wu Q, Hu M, et al. Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons. J Cell Biol. 2016;215:369-381 pubmed
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5b
  • western blot; mouse; loading ...; fig 7d
Kunii M, Ohara Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, et al. Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells. J Cell Biol. 2016;215:121-138 pubmed
  • western blot; mouse; loading ...; fig 3a
Sclip A, Bacaj T, Giam L, Sudhof T. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. PLoS ONE. 2016;11:e0158295 pubmed publisher
  • western blot; human; 1:10,000; fig 6B
Benítez B, Cairns N, Schmidt R, Morris J, Norton J, Cruchaga C, et al. Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss. Acta Neuropathol Commun. 2015;3:73 pubmed publisher
  • western blot; rat; fig 1
Wang C, Wang Y, Hu M, Chai Z, Wu Q, Huang R, et al. Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Rep. 2016;17:47-63 pubmed publisher
  • western blot; human; fig 8
  • western blot; mouse; fig 6
Bacaj T, Wu D, Burré J, Malenka R, Liu X, Sudhof T. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. PLoS Biol. 2015;13:e1002267 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 5
  • western blot; mouse; fig 5
Zulliger R, Conley S, Mwoyosvi M, Stuck M, Azadi S, Naash M. SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PLoS ONE. 2015;10:e0138508 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 5
Williams M, DeSpenza T, Li M, Gulledge A, Luikart B. Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive. J Neurosci. 2015;35:943-59 pubmed publisher
  • immunocytochemistry; rat
  • western blot; rat
Shinoda Y, Ahmed S, Ramachandran B, Bharat V, Brockelt D, Altas B, et al. BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons. Front Synaptic Neurosci. 2014;6:27 pubmed publisher
  • western blot; mouse; 1:200; fig 2
Blanchard J, Eade K, Szucs A, Lo Sardo V, Tsunemoto R, Williams D, et al. Selective conversion of fibroblasts into peripheral sensory neurons. Nat Neurosci. 2015;18:25-35 pubmed publisher
  • immunocytochemistry; mouse
  • immunocytochemistry; rat
Hiasa M, Miyaji T, Haruna Y, Takeuchi T, Harada Y, Moriyama S, et al. Identification of a mammalian vesicular polyamine transporter. Sci Rep. 2014;4:6836 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2c
  • western blot; mouse; fig 2
Messenger S, Falkowski M, Thomas D, Jones E, Hong W, Gaisano H, et al. Vesicle associated membrane protein 8 (VAMP8)-mediated zymogen granule exocytosis is dependent on endosomal trafficking via the constitutive-like secretory pathway. J Biol Chem. 2014;289:28040-53 pubmed publisher
  • western blot; rat
Zhao H, Kim Y, Park J, Park D, Lee S, Chang I, et al. SCAMP5 plays a critical role in synaptic vesicle endocytosis during high neuronal activity. J Neurosci. 2014;34:10085-95 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
  • immunocytochemistry; rat
  • western blot; rat
  • western blot; human
Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, et al. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014;10:e1004177 pubmed publisher
  • western blot; mouse
Ster J, Steuble M, Orlando C, Diep T, Akhmedov A, Raineteau O, et al. Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development. J Neurosci. 2014;34:8716-27 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Walter A, Kurps J, de Wit H, Sch ning S, Toft Bertelsen T, Lauks J, et al. The SNARE protein vti1a functions in dense-core vesicle biogenesis. EMBO J. 2014;33:1681-97 pubmed publisher
  • western blot; mouse; fig 6
Lee S, Sharma M, S dhof T, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014;111:8973-8 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
  • immunocytochemistry; rat
  • western blot; rat
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
  • immunohistochemistry; mouse
Cijsouw T, Weber J, Broeke J, Broek J, Schut D, Kroon T, et al. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner. J Cell Biol. 2014;204:759-75 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:250
  • western blot; rat; 1:1000
Manca P, Mameli O, Caria M, Torrej n Escribano B, Blasi J. Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration. Neuroscience. 2014;266:102-15 pubmed publisher
  • immunocytochemistry; rat
Vazquez Cintron E, Vakulenko M, Band P, Stanker L, Johnson E, Ichtchenko K. Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm. PLoS ONE. 2014;9:e85517 pubmed publisher
  • immunohistochemistry; human
Hoshino S, Sakamoto K, Vassilopoulos S, Camus S, Griffin C, Esk C, et al. The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration. PLoS ONE. 2013;8:e77787 pubmed publisher
  • western blot; mouse
Yun H, Park J, Ho D, Kim H, Kim C, Oh H, et al. LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp Mol Med. 2013;45:e36 pubmed publisher
  • western blot; mouse
Yao J, de la Iglesia H, Bajjalieh S. Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice. PLoS ONE. 2013;8:e68215 pubmed publisher
  • immunocytochemistry; rat
Giannandrea M, Guarnieri F, Gehring N, Monzani E, Benfenati F, Kulozik A, et al. Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I. PLoS ONE. 2013;8:e67724 pubmed publisher
  • immunocytochemistry; rat
Spangler S, Schmitz S, Kevenaar J, de Graaff E, de Wit H, Demmers J, et al. Liprin-?2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. J Cell Biol. 2013;201:915-28 pubmed publisher
  • immunocytochemistry; mouse
Pielarski K, van Stegen B, Andreyeva A, Nieweg K, J ngling K, Redies C, et al. Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons. PLoS ONE. 2013;8:e54105 pubmed publisher
  • immunocytochemistry; human
Rodr guez F, Zanetti M, Mayorga L, Tomes C. Munc18-1 controls SNARE protein complex assembly during human sperm acrosomal exocytosis. J Biol Chem. 2012;287:43825-39 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Mainardi M, Pietrasanta M, Vannini E, Rossetto O, Caleo M. Tetanus neurotoxin-induced epilepsy in mouse visual cortex. Epilepsia. 2012;53:e132-6 pubmed publisher
  • immunohistochemistry; mouse
Iijima T, Wu K, Witte H, Hanno Iijima Y, Glatter T, Richard S, et al. SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1. Cell. 2011;147:1601-14 pubmed publisher
  • immunoprecipitation; mouse
  • western blot; mouse
Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T. Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 2012;279:384-94 pubmed publisher
  • immunohistochemistry; mouse
Kalinovsky A, Boukhtouche F, Blazeski R, Bornmann C, Suzuki N, Mason C, et al. Development of axon-target specificity of ponto-cerebellar afferents. PLoS Biol. 2011;9:e1001013 pubmed publisher
  • western blot; mouse
Sharma M, Burr J, S dhof T. CSP? promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol. 2011;13:30-9 pubmed publisher
  • western blot; mouse
  • immunocytochemistry; rat
Yeh F, Dong M, Yao J, Tepp W, Lin G, Johnson E, et al. SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathog. 2010;6:e1001207 pubmed publisher
  • western blot; mouse
Camoletto P, Vara H, Morando L, Connell E, Marletto F, Giustetto M, et al. Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18. PLoS ONE. 2009;4:e5310 pubmed publisher
  • western blot; mouse
Morgans C, Kensel Hammes P, Hurley J, Burton K, IDZERDA R, McKnight G, et al. Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. PLoS ONE. 2009;4:e5230 pubmed publisher
  • immunocytochemistry; rat
Perez Gonzalez A, Albrecht D, Blasi J, Llobet A. Schwann cells modulate short-term plasticity of cholinergic autaptic synapses. J Physiol. 2008;586:4675-91 pubmed publisher
  • immunohistochemistry; rat
Tajika Y, Murakami T, Sato M, Kubota F, Yorifuji H. VAMP2 is expressed in myogenic cells during rat development. Dev Dyn. 2008;237:1886-92 pubmed publisher
  • western blot; human
Sander L, Frank S, Bolat S, Blank U, Galli T, Bigalke H, et al. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol. 2008;38:855-63 pubmed publisher
  • western blot; mouse
Puri N, Roche P. Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms. Proc Natl Acad Sci U S A. 2008;105:2580-5 pubmed publisher
  • immunocytochemistry; human
De Blas G, Roggero C, Tomes C, Mayorga L. Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis. PLoS Biol. 2005;3:e323 pubmed publisher
Velasco C, Llobet A. Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit. Commun Biol. 2020;3:260 pubmed publisher
Torre Muruzabal T, Devoght J, Van den Haute C, Brône B, Van der Perren A, Baekelandt V. Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease. Acta Neuropathol Commun. 2019;7:160 pubmed publisher
Lazarevic V, Mantas I, Flais I, Svenningsson P. Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex. Int J Mol Sci. 2019;20: pubmed publisher
Kreutzberger A, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, et al. In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. Nat Commun. 2019;10:3904 pubmed publisher
Golec E, Rosberg R, Zhang E, Renstrom E, Blom A, King B. A cryptic non-GPI-anchored cytosolic isoform of CD59 controls insulin exocytosis in pancreatic β-cells by interaction with SNARE proteins. FASEB J. 2019;:fj201901007R pubmed publisher
Lasič E, Lisjak M, Horvat A, Božić M, Šakanović A, Anderluh G, et al. Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action. Sci Rep. 2019;9:10957 pubmed publisher
Röhl J, West Z, Rudolph M, Zaharia A, Van Lonkhuyzen D, Hickey D, et al. Invasion by activated macrophages requires delivery of nascent membrane-type-1 matrix metalloproteinase through late endosomes/lysosomes to the cell surface. Traffic. 2019;20:661-673 pubmed publisher
Navarrete M, Cuartero M, Palenzuela R, Draffin J, Konomi A, Serra I, et al. Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory. Nat Commun. 2019;10:2968 pubmed publisher
Pellett S, Tepp W, Johnson E. Botulinum neurotoxins A, B, C, E, and F preferentially enter cultured human motor neurons compared to other cultured human neuronal populations. FEBS Lett. 2019;593:2675-2685 pubmed publisher
Ruete M, Zarelli V, Masone D, de Paola M, Bustos D, Tomes C. A connection between reversible tyrosine phosphorylation and SNARE complex disassembly activity of N-ethylmaleimide-sensitive factor unveiled by the phosphomimetic mutant N-ethylmaleimide-sensitive factor-Y83E. Mol Hum Reprod. 2019;25:344-358 pubmed publisher
Liu Y, Sugiura Y, Sudhof T, Lin W. Ablation of all synaptobrevin vSNAREs blocks evoked but not spontaneous neurotransmitter release at neuromuscular synapses. J Neurosci. 2019;: pubmed publisher
Irfan M, Gopaul K, Miry O, Hokfelt T, Stanton P, Bark C. SNAP-25 isoforms differentially regulate synaptic transmission and long-term synaptic plasticity at central synapses. Sci Rep. 2019;9:6403 pubmed publisher
Lin A, Henry S, Reissner C, Neupert C, Kenny C, Missler M, et al. A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function. Sci Rep. 2019;9:6024 pubmed publisher
Weiss A. Synaptobrevin-2 C-Terminal Flexible Region Regulates the Discharge of Catecholamine Molecules. Biophys J. 2019;116:921-929 pubmed publisher
Zurawski Z, Thompson Gray A, Brady L, Page B, Church E, Harris N, et al. Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Sci Signal. 2019;12: pubmed publisher
Peggion C, Stella R, Chemello F, Massimino M, Arrigoni G, Cagnin S, et al. The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis. Mol Neurobiol. 2019;56:3420-3436 pubmed publisher
Duan M, Yan M, Wang Q, Mao M, Su D, Sun L, et al. Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes. Cell Commun Signal. 2018;16:91 pubmed publisher
Wolter S, Möhrle D, Schmidt H, Pfeiffer S, Zelle D, Eckert P, et al. GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing. Front Neural Circuits. 2018;12:65 pubmed publisher
Shen C, Liu Y, Yu H, Gulbranson D, Kogut I, Bilousova G, et al. The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis. J Biol Chem. 2018;293:18309-18317 pubmed publisher
Emperador Melero J, Huson V, Van Weering J, Bollmann C, Fischer von Mollard G, Toonen R, et al. Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Nat Commun. 2018;9:3421 pubmed publisher
Yu H, Shen C, Liu Y, Menasche B, Ouyang Y, Stowell M, et al. SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins. Proc Natl Acad Sci U S A. 2018;115:E8421-E8429 pubmed publisher
Chiang C, Chang C, Jackson M. The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux through Synaptic Fusion Pores. J Neurosci. 2018;38:7179-7191 pubmed publisher
Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, et al. Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system. J Neurochem. 2018;146:374-389 pubmed publisher
Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer E, et al. Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity. elife. 2018;7: pubmed publisher
Daraio T, Valladolid Acebes I, Brismar K, Bark C. SNAP-25a and SNAP-25b differently mediate interactions with Munc18-1 and Gβγ subunits. Neurosci Lett. 2018;674:75-80 pubmed publisher
Kovacević J, Maroteaux G, Schut D, Loos M, Dubey M, Pitsch J, et al. Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy. Brain. 2018;141:1350-1374 pubmed publisher
Lautenschläger J, Stephens A, Fusco G, Ströhl F, Curry N, Zacharopoulou M, et al. C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction. Nat Commun. 2018;9:712 pubmed publisher
Vazquez Sanchez S, Bobeldijk S, Dekker M, van Keimpema L, van Weering J. VPS35 depletion does not impair presynaptic structure and function. Sci Rep. 2018;8:2996 pubmed publisher
McInnes J, Wierda K, Snellinx A, Bounti L, Wang Y, Stancu I, et al. Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. 2018;97:823-835.e8 pubmed publisher
Zhang S, Lebreton F, Mansfield M, Miyashita S, Zhang J, Schwartzman J, et al. Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host Microbe. 2018;23:169-176.e6 pubmed publisher
Harada Y, Kato Y, Miyaji T, Omote H, Moriyama Y, Hiasa M. Vesicular nucleotide transporter mediates ATP release and migration in neutrophils. J Biol Chem. 2018;293:3770-3779 pubmed publisher
Houy S, Groffen A, Ziomkiewicz I, Verhage M, Pinheiro P, Sørensen J. Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs. elife. 2017;6: pubmed publisher
Meijer M, Dörr B, Lammertse H, Blithikioti C, van Weering J, Toonen R, et al. Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly. EMBO J. 2018;37:300-320 pubmed publisher
Richter K, Revelo N, Seitz K, Helm M, Sarkar D, Saleeb R, et al. Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy. EMBO J. 2018;37:139-159 pubmed publisher
Ferro M, Lamanna J, Ripamonti M, Racchetti G, Arena A, Spadini S, et al. Functional mapping of brain synapses by the enriching activity-marker SynaptoZip. Nat Commun. 2017;8:1229 pubmed publisher
Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher
Mazzotti C, Gagliostro V, Bosisio D, Del Prete A, Tiberio L, Thelen M, et al. The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells. Front Immunol. 2017;8:1233 pubmed publisher
Tomatis V, Josh P, Papadopulos A, Gormal R, Lanoue V, Martin S, et al. ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network. Mol Cell Neurosci. 2017;84:100-111 pubmed publisher
Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, et al. Identification and characterization of a novel botulinum neurotoxin. Nat Commun. 2017;8:14130 pubmed publisher
Lasič E, Stenovec M, Kreft M, Robinson P, Zorec R. Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements. Biochim Biophys Acta Gen Subj. 2017;1861:2293-2303 pubmed publisher
Sando R, Bushong E, Zhu Y, Huang M, Considine C, Phan S, et al. Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission. Neuron. 2017;94:312-321.e3 pubmed publisher
Messenger S, Jones E, Holthaus C, Thomas D, Cooley M, Byrne J, et al. Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation. J Biol Chem. 2017;292:7828-7839 pubmed publisher
Sharif M, Silva E, Shah S, Miller D. Redistribution of soluble N-ethylmaleimide-sensitive-factor attachment protein receptors in mouse sperm membranes prior to the acrosome reaction. Biol Reprod. 2017;96:352-365 pubmed publisher
Burk K, Ramachandran B, Ahmed S, Hurtado Zavala J, Awasthi A, Benito E, et al. Regulation of Dendritic Spine Morphology in Hippocampal Neurons by Copine-6. Cereb Cortex. 2018;28:1087-1104 pubmed publisher
Romanov R, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, et al. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nat Neurosci. 2017;20:176-188 pubmed publisher
Honma S, Kadono K, Kawano A, Wakisaka S. Immunohistochemical localization of SNARE core proteins in intrapulpal and intradentinal nerve fibers of rat molar teeth. Arch Oral Biol. 2017;73:248-252 pubmed publisher
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product information
Cat. Nr. :
104 211
Antigen :
Synaptobrevin 2
Synonyms :
VAMP 2, p18-2, Vamp2
Host Species :
mouse
Tpye :
monoclonal
Form :
purified IgG
Cell Line :
69.1
Subtype :
IgG1
Immunogen :
Synthetic peptide corresponding to AA 2 to 17 from rat Synaptobrevin2 (UniProt Id: P63045)
Reactivity :
human, rat, mouse, hamster
WB :
WB
IP :
IP
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
EM :
EM
ELISA :
ELISA
KO :
yes
KD :
yes
Quantity :
50 µg
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany