product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Synaptobrevin 2
catalog :
104 202
quantity :
200 µl
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
/
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; fig 1g
  • western blot; mouse; fig s1c
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser P. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018;172:706-718.e15 pubmed publisher
  • immunocytochemistry; rat; 1:1000; loading ...; fig 5c
  • western blot; rat; 1:1000; loading ...; fig 5a
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  • immunocytochemistry; rat; fig 2
Tagliatti E, Fadda M, Falace A, Benfenati F, Fassio A. Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse. elife. 2016;5: pubmed publisher
  • immunocytochemistry; rat; 1:500; fig S4
Craig T, Anderson D, Evans A, Girach F, Henley J. SUMOylation of Syntaxin1A regulates presynaptic endocytosis. Sci Rep. 2015;5:17669 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 5c
Tang L, Craig T, Henley J. SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation. Nat Commun. 2015;6:7728 pubmed publisher
  • western blot; mouse; 1:2500
Beccano Kelly D, Kuhlmann N, Tatarnikov I, Volta M, Munsie L, Chou P, et al. Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. Front Cell Neurosci. 2014;8:301 pubmed publisher
  • immunocytochemistry; mouse
Verstegen A, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, et al. Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses. J Neurosci. 2014;34:7266-80 pubmed publisher
  • immunohistochemistry; mouse
Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, et al. Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. J Neurosci. 2014;34:5788-99 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:250
  • western blot; rat; 1:1000
Manca P, Mameli O, Caria M, Torrej n Escribano B, Blasi J. Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration. Neuroscience. 2014;266:102-15 pubmed publisher
  • immunohistochemistry; mouse
Larimore J, Ryder P, Kim K, Ambrose L, Chapleau C, Calfa G, et al. MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons. PLoS ONE. 2013;8:e65069 pubmed publisher
  • western blot; rat
Dettmer U, Newman A, Luth E, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of ?-synuclein and ?-synuclein in neurons and non-neural cells. J Biol Chem. 2013;288:6371-85 pubmed publisher
  • immunohistochemistry; mouse
Nakashiba T, Cushman J, Pelkey K, Renaudineau S, Buhl D, McHugh T, et al. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell. 2012;149:188-201 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000
Phillips M, Otteson D, Sherry D. Progression of neuronal and synaptic remodeling in the rd10 mouse model of retinitis pigmentosa. J Comp Neurol. 2010;518:2071-89 pubmed publisher
Yao W, Tambini M, Liu X, D ADAMIO L. Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage. J Neurosci. 2019;: pubmed publisher
Toledo A, Lang F, Doengi M, Morrison H, Stein V, Baader S. Merlin modulates process outgrowth and synaptogenesis in the cerebellum. Brain Struct Funct. 2019;224:2121-2142 pubmed publisher
Wegrzynowicz M, Bar On D, Calò L, Anichtchik O, Iovino M, Xia J, et al. Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. Acta Neuropathol. 2019;: pubmed publisher
Orock A, Logan S, Deak F. Age-related cognitive impairment: Role of reduced synaptobrevin-2 levels in memory and synaptic plasticity deficits. J Gerontol A Biol Sci Med Sci. 2019;: pubmed publisher
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, et al. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019;363: pubmed publisher
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, et al. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. EMBO J. 2018;37: pubmed publisher
Kerov V, Laird J, Joiner M, Knecht S, Soh D, Hagen J, et al. α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses. J Neurosci. 2018;38:6145-6160 pubmed publisher
Li W, Chu M, Wu A, Suzuki Y, Imayoshi I, Komiyama T. Adult-born neurons facilitate olfactory bulb pattern separation during task engagement. elife. 2018;7: pubmed publisher
Lautenschläger J, Stephens A, Fusco G, Ströhl F, Curry N, Zacharopoulou M, et al. C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction. Nat Commun. 2018;9:712 pubmed publisher
Borisovska M. Syntaxins on granules promote docking of granules via interactions with munc18. Sci Rep. 2018;8:193 pubmed publisher
Riemann D, Wallrafen R, Dresbach T. The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein. Sci Rep. 2017;7:15791 pubmed publisher
Zhang X, Jiang S, Mitok K, Li L, Attie A, Martin T. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. J Cell Biol. 2017;216:2151-2166 pubmed publisher
Bademosi A, Lauwers E, Padmanabhan P, Odierna L, Chai Y, Papadopulos A, et al. In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nat Commun. 2017;8:13660 pubmed publisher
Niederkofler V, Asher T, Okaty B, Rood B, Narayan A, Hwa L, et al. Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior. Cell Rep. 2016;17:1934-1949 pubmed publisher
Kasula R, Chai Y, Bademosi A, Harper C, Gormal R, Morrow I, et al. The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. J Cell Biol. 2016;214:847-58 pubmed publisher
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni R, et al. PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. Cell Rep. 2016;15:117-131 pubmed publisher
Rajappa R, Gauthier Kemper A, Böning D, Hüve J, Klingauf J. Synaptophysin 1 Clears Synaptobrevin 2 from the Presynaptic Active Zone to Prevent Short-Term Depression. Cell Rep. 2016;14:1369-1381 pubmed publisher
Harper C, Papadopulos A, Martin S, Matthews D, Morgan G, Nguyen T, et al. Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles. Sci Rep. 2016;6:19654 pubmed publisher
Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed publisher
Ulloa F, Gonzàlez Juncà A, Meffre D, Barrecheguren P, Martínez Mármol R, Pazos I, et al. Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth. PLoS ONE. 2015;10:e0119707 pubmed publisher
Sadler J, Bryant N, Gould G. Characterization of VAMP isoforms in 3T3-L1 adipocytes: implications for GLUT4 trafficking. Mol Biol Cell. 2015;26:530-6 pubmed publisher
Ferecskó A, Jiruska P, Foss L, Powell A, Chang W, Sik A, et al. Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy. Brain Struct Funct. 2015;220:1013-29 pubmed publisher
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T. Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission. Eur J Neurosci. 2012;36:3005-20 pubmed publisher
Orenbuch A, Shalev L, Marra V, Sinai I, Lavy Y, Kahn J, et al. Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals. J Neurosci. 2012;32:3969-80 pubmed publisher
Leiss F, Groh C, Butcher N, Meinertzhagen I, Tavosanis G. Synaptic organization in the adult Drosophila mushroom body calyx. J Comp Neurol. 2009;517:808-24 pubmed publisher
Sander L, Frank S, Bolat S, Blank U, Galli T, Bigalke H, et al. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol. 2008;38:855-63 pubmed publisher
Sherry D, Wang M, Frishman L. Differential distribution of vesicle associated membrane protein isoforms in the mouse retina. Mol Vis. 2003;9:673-88 pubmed
Oorschot V, de Wit H, Annaert W, Klumperman J. A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation. J Histochem Cytochem. 2002;50:1067-80 pubmed publisher
product information
Company Name :
Synaptic Systems
Cat. Nr. :
104 202
Antigen :
Synaptobrevin 2
Synonyms :
VAMP 2, p18-2, Vamp2
Host Species :
rabbit
Tpye :
polyclonal
Form :
antiserum
Immunogen :
Synthetic peptide corresponding to AA 2 to 17 from rat Synaptobrevin2 (UniProt Id: P63045)
Reactivity :
human, rat, mouse, hamster
WB :
y
IP :
y
ICC :
y
IHC :
y
IHC P :
y
EM :
y
KD :
1
Quantity :
200 µl
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany