product summary
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company name :
Synaptic Systems
product type :
antibody
product name :
Synaptophysin 1
catalog :
101 004
quantity :
100 µl
clonality :
polyclonal
host :
guinea-pigs
conjugate :
nonconjugated
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 55
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig s3b
Van Alstyne M, Tattoli I, Delestrée N, Recinos Y, Workman E, Shihabuddin L, et al. Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit. Nat Neurosci. 2021;24:930-940 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1b
  • immunohistochemistry - frozen section; rat; loading ...; fig 1g
Rojek K, Krzemien J, Dolezyczek H, Boguszewski P, Kaczmarek L, Konopka W, et al. Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. PLoS Biol. 2019;17:e3000253 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 6c
  • western blot; mouse; 1:2000; fig 3i
Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher
  • immunocytochemistry; mouse; 1:2000; loading ...; fig 2c
Orav E, Atanasova T, Shintyapina A, Kesaf S, Kokko M, Partanen J, et al. NETO1 Guides Development of Glutamatergic Connectivity in the Hippocampus by Regulating Axonal Kainate Receptors. Eneuro. 2017;4: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig s6c
McCracken K, Aihara E, Martin B, Crawford C, Broda T, Treguier J, et al. Wnt/β-catenin promotes gastric fundus specification in mice and humans. Nature. 2017;541:182-187 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 1c
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 4
Venugopalan P, Wang Y, Nguyen T, Huang A, Muller K, Goldberg J. Transplanted neurons integrate into adult retinas and respond to light. Nat Commun. 2016;7:10472 pubmed publisher
Sertel S, von Elling Tammen M, Rizzoli S. The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons. J Neurosci. 2021;41:1157-1173 pubmed publisher
Chantranupong L, Saulnier J, Wang W, Jones D, Pacold M, Sabatini B. Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain. elife. 2020;9: pubmed publisher
Even A, Morelli G, Broix L, Scaramuzzino C, Turchetto S, Gladwyn Ng I, et al. ATAT1-enriched vesicles promote microtubule acetylation via axonal transport. Sci Adv. 2019;5:eaax2705 pubmed publisher
Vukojicic A, Delestrée N, Fletcher E, Pagiazitis J, Sankaranarayanan S, Yednock T, et al. The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA. Cell Rep. 2019;29:3087-3100.e7 pubmed publisher
Min S, Chang R, Prescott S, Beeler B, Joshi N, Strochlic D, et al. Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws. Cell Rep. 2019;29:2192-2201.e3 pubmed publisher
Urban I, Kerimoglu C, Sakib M, Wang H, Benito E, Thaller C, et al. TIP60/KAT5 is required for neuronal viability in hippocampal CA1. Sci Rep. 2019;9:16173 pubmed publisher
Schwenk J, Boudkkazi S, Kocylowski M, Brechet A, Zolles G, Bus T, et al. An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity. Neuron. 2019;104:680-692.e9 pubmed publisher
Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, et al. FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis. Nat Neurosci. 2019;22:1793-1805 pubmed publisher
Grycz K, Głowacka A, Ji B, Czarkowska Bauch J, Gajewska Wozniak O, Skup M. Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study. PLoS ONE. 2019;14:e0222849 pubmed publisher
Mitroi D, Pereyra Gómez G, Soto Huelin B, Senovilla F, Kobayashi T, Esteban J, et al. NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation. EMBO Rep. 2019;20:e48143 pubmed publisher
Courtney N, Bao H, Briguglio J, Chapman E. Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin. Nat Commun. 2019;10:4076 pubmed publisher
Gao X, Grendel J, Muhia M, Castro Gomez S, Süsens U, Isbrandt D, et al. Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice. J Neurosci. 2019;: pubmed publisher
Lazarevic V, Mantas I, Flais I, Svenningsson P. Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex. Int J Mol Sci. 2019;20: pubmed publisher
Ojelade S, Lee T, Giagtzoglou N, Yu L, Ugur B, Li Y, et al. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019;28:1799-1813.e5 pubmed publisher
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner J, Oldani S, et al. SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering. EMBO J. 2019;38:e101289 pubmed publisher
Garber C, Soung A, Vollmer L, Kanmogne M, Last A, Brown J, et al. T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses. Nat Neurosci. 2019;: pubmed publisher
Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, et al. Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury. NPJ Regen Med. 2019;4:13 pubmed publisher
Oz Levi D, Olender T, Bar Joseph I, Zhu Y, Marek Yagel D, Barozzi I, et al. Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019;: pubmed publisher
Zhang X, McGrath P, Salomone J, Rahal M, McCauley H, Schweitzer J, et al. A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development. Dev Cell. 2019;: pubmed publisher
Verschuuren M, Verstraelen P, Garcia Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, et al. High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity. Acta Neuropathol Commun. 2019;7:6 pubmed publisher
King C, A A Quadros A, Chazeau A, Saarloos I, van der Graaf A, Verhage M, et al. Fbxo41 Promotes Disassembly of Neuronal Primary Cilia. Sci Rep. 2019;9:8179 pubmed publisher
Reinehr S, Reinhard J, Wiemann S, Hesse K, Voss C, Gandej M, et al. Transfer of the Experimental Autoimmune Glaucoma Model from Rats to Mice-New Options to Study Glaucoma Disease. Int J Mol Sci. 2019;20: pubmed publisher
Ackermann F, Schink K, Bruns C, Izsvák Z, Hamra F, Rosenmund C, et al. Critical role for Piccolo in synaptic vesicle retrieval. elife. 2019;8: pubmed publisher
Orav E, Dowavic I, Huupponen J, Taira T, Lauri S. NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation. Mol Neurobiol. 2019;: pubmed publisher
Truckenbrodt S, Sommer C, Rizzoli S, Danzl J. A practical guide to optimization in X10 expansion microscopy. Nat Protoc. 2019;14:832-863 pubmed publisher
Wallrafen R, Dresbach T, Viotti J. Quantifying the Heterogeneous Distribution of a Synaptic Protein in the Mouse Brain Using Immunofluorescence. J Vis Exp. 2019;: pubmed publisher
Merlini M, Rafalski V, Rios Coronado P, Gill T, Ellisman M, Muthukumar G, et al. Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Neuron. 2019;101:1099-1108.e6 pubmed publisher
Maidorn M, Olichon A, Rizzoli S, Opazo F. Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons. MAbs. 2019;11:305-321 pubmed publisher
Dejanovic B, Huntley M, De Mazière A, Meilandt W, Wu T, Srinivasan K, et al. Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies. Neuron. 2018;100:1322-1336.e7 pubmed publisher
Ruyle B, Klutho P, Baines C, Heesch C, Hasser E. Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii. Am J Physiol Regul Integr Comp Physiol. 2018;315:R1167-R1182 pubmed publisher
Emperador Melero J, Huson V, Van Weering J, Bollmann C, Fischer von Mollard G, Toonen R, et al. Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Nat Commun. 2018;9:3421 pubmed publisher
Wallrafen R, Dresbach T. The Presynaptic Protein Mover Is Differentially Expressed Across Brain Areas and Synapse Types. Front Neuroanat. 2018;12:58 pubmed publisher
Chiang C, Chang C, Jackson M. The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux through Synaptic Fusion Pores. J Neurosci. 2018;38:7179-7191 pubmed publisher
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, et al. Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission. EMBO J. 2018;37: pubmed publisher
Yuan X, Klein D, Kerscher S, West B, Weis J, Katona I, et al. Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice. J Neurosci. 2018;38:4610-4620 pubmed publisher
de Jong A, Roggero C, Ho M, Wong M, Brautigam C, Rizo J, et al. RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes. Neuron. 2018;98:335-349.e7 pubmed publisher
Mikhaylova M, Bär J, van Bommel B, Schätzle P, Yuanxiang P, Raman R, et al. Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines. Neuron. 2018;97:1110-1125.e14 pubmed publisher
Bloss E, Cembrowski M, Karsh B, Colonell J, Fetter R, Spruston N. Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites. Nat Neurosci. 2018;21:353-363 pubmed publisher
Garber C, Vasek M, Vollmer L, Sun T, Jiang X, Klein R. Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1. Nat Immunol. 2018;19:151-161 pubmed publisher
Domínguez N, van Weering J, Borges R, Toonen R, Verhage M. Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B. J Neurochem. 2018;144:241-254 pubmed publisher
Krishtal J, Bragina O, Metsla K, Palumaa P, Tougu V. In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells. PLoS ONE. 2017;12:e0186636 pubmed publisher
Rudnick N, Griffey C, Guarnieri P, Gerbino V, Wang X, Piersaint J, et al. Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS. Proc Natl Acad Sci U S A. 2017;114:E8294-E8303 pubmed publisher
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, et al. Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice. Neurobiol Dis. 2017;106:255-268 pubmed publisher
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, et al. APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci. 2017;37:5345-5365 pubmed publisher
Barad Z, Grattan D, Leitch B. NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy. Sci Rep. 2017;7:42926 pubmed publisher
Wang S, Held R, Wong M, Liu C, Karakhanyan A, Kaeser P. Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking. Neuron. 2016;91:777-791 pubmed publisher
Bai H, Xue R, Bao H, Zhang L, Yethiraj A, Cui Q, et al. Different states of synaptotagmin regulate evoked versus spontaneous release. Nat Commun. 2016;7:10971 pubmed publisher
Chang C, Chiang C, Gaffaney J, Chapman E, Jackson M. Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion. J Biol Chem. 2016;291:2848-57 pubmed publisher
product information
Cat. Nr. :
101 004
Antigen :
Synaptophysin 1
Synonyms :
p38-1, Synaptophysin1
Host Species :
Guinea pig
Tpye :
polyclonal
Form :
antiserum
Immunogen :
Synthetic peptide corresponding to AA 301 to 313 from human Synaptophysin1 (UniProt Id: P08247)
Reactivity :
human, rat, mouse, hamster, cow, chicken, frog
WB :
WB
IP :
IP
ICC :
ICC
IHC :
IHC
IHC P :
IHC-P
Quantity :
100 µl
more info or order :
company information
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
headquarters: germany