product summary
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company name :
StressMarq Biosciences
product type :
protein
product name :
Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated)
catalog :
SPR-516
quantity :
100 µg
more info or order :
StressMarq Biosciences product webpage
image
image 1 :
StressMarq Biosciences SPR-516 image 1
Representative TEM image of Cho-expressed Tau 2N4R P301S Pre-Formed Fibrils (SPR-516), 200nm scale. Negative stain transmission electron microscopy images of SPR-516 acquired at 80 Kv on carbon coated 400 mesh copper grids using phosphotungstic acid and uranyl acetate stain.
image 2 :
StressMarq Biosciences SPR-516 image 2
Native-PAGE of CHO-expressed Tau monomers (SPR-515) & fibrils (SPR-516) on a 12% Tris-glycine gel (no SDS). Lane 1: Biorad All Blue Standards (4uL). Lane 2: CHO-expressed hTau 2N4R P301S monomer (2ug). Lane 3: CHO-expressed hTau 2N4R P301S fibril (2ug). Lane 4: n/a. Lane 5: CHO-expressed hTau 2N4R P301S monomer (4ug). Lane 6: CHO-expressed hTau 2N4R P301S fibril (4ug). Note: native proteins typically migrate much slower through a gel compared to reduced, SDS-treated MW standards.
image 3 :
StressMarq Biosciences SPR-516 image 3
ThT fluorescence (excitation at 450nm, emission at 485nm) of CHO-expressed Tau monomers (SPR-515) and pre-formed fibrils (SPR-516). The graph shows an increased ThT signal in 5 & 50 ug of fibrils compared to 5 & 50 ug of monomers.
product information
Catalog No :
SPR-516
Product Name :
Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated)
Description :
Human Recombinant Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated)
Size :
100 µg
Research Area(s) :
Neuroscience Neurodegeneration Alzheimer's Disease Tangles & Tau
Alternative Name(s) :
MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R
Category :
Protein
Nature :
Recombinant
Swiss-Prot :
P10636-8
Applications :
WB SDS PAGE In vitro Assay
Species :
Human
Expression System :
Chinese Hamster Ovary (CHO)
Protein Length :
441 aa (excluding tag), 466 aa (including tag)
Amino Acid Sequence :
GGSHHHHHHHHHHGSGGSENLYFQGMAEPRQEFEVMEDH
AGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTE
DGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQ
PHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKS
KDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATR
IPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSR
SRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPV
PMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNV
QSKCGSKDNIKHVSGGGSVQIVYKPVDLSKVTSKCGSLG
NIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPG
GGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTS
PRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Purity :
>95%
Protein Size :
48.609 kDa
Conjugate :
N-term histidine tag & TEV site
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.