product summary
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company name :
StressMarq Biosciences
product type :
protein
product name :
Amyloid Beta 1-42 Oligomers
catalog :
SPR-488
quantity :
100 µg
more info or order :
StressMarq Biosciences product webpage
citations: 5
Reference
Mishra S, Morshed N, Sindhu S, Kinoshita C, Stevens B, Jayadev S, et al. The Alzheimer's disease gene SORL1 regulates lysosome function in human microglia. bioRxiv. 2025;: pubmed publisher
Fukumoto H, Kao T, Tai C, Jang M, Miyamoto M. High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005). FASEB J. 2024;38:e70160 pubmed publisher
Chiang W, Urban J, Yanchik Slade F, Stout A, Hammond J, Nilsson B, et al. Hybrid Amyloid Quantum Dot Nano-Bio Assemblies to Probe Neuroinflammatory Damage. ACS Chem Neurosci. 2024;15:3124-3135 pubmed publisher
Kim A, Xiao Q, Yan P, Pan Q, Pandey G, Grathwohl S, et al. Chimeric antigen receptor macrophages target and resorb amyloid plaques. JCI Insight. 2024;9: pubmed publisher
Chen K, Martens Y, Meneses A, Ryu D, Lu W, Raulin A, et al. LRP1 is a neuronal receptor for α-synuclein uptake and spread. Mol Neurodegener. 2022;17:57 pubmed publisher
image
image 1 :
StressMarq Biosciences SPR-488 image 1
TEM of amyloid beta 1-42 oligomers (SPR-488). Negative stain transmission electron microscopy images acquired at 80 Kv on carbon coated 400 mesh copper grids using phosphotungstic acid and uranyl acetate stain. Scale bar = 100 nm.
image 2 :
StressMarq Biosciences SPR-488 image 2
AFM of amyloid beta 1-42 oligomers (SPR-488). Atomic force microscopy analysis of 1.0 mg/mL samples diluted to 0.1 mg/mL in dH2O, mounted on freshly cleaved mica, washed, dried and analyzed with tapping mode. Representative images are 2.5 x 2.5 µm x-y with a z-range of 10 nm.
image 3 :
StressMarq Biosciences SPR-488 image 3
Western blot of amyloid beta 1-42 monomers (SPR-485, left), oligomers (SPR-488, middle) and fibrils (SPR-487, right) using anti-amyloid beta 6E10 antibody. Amyloid beta constructs at 160 pmol were run on 4-12% Bis-Tris SDS-PAGE, transferred to nitrocellulose in the presence of 0.02% v/v Tween-20, and blotted with 1:1000 mouse 6E10 primary antibody (Biolegend). Oligomers observed under TEM/AFM show distinct dimer/trimer bands as well as a signal from ~37-75 kDa (middle). Fibrils observed under TEM/AFM show a signal greater than 100 kDa and a distinct signal in the stacking gel (right).
product information
Catalog No :
SPR-488
Product Name :
Amyloid Beta 1-42 Oligomers
Description :
Human Synthetic Amyloid Beta 1-42 Oligomers
Size :
100 µg
Research Area(s) :
Neuroscience Neurodegeneration Alzheimer's Disease Amyloid
Alternative Name(s) :
Abeta Oligomers, Abeta peptide, Amyloid beta peptide oligomers, Beta amyloid peptide oligomers, amyloid beta precursor protein peptide oligomers, APP
Category :
Protein
Nature :
Synthetic (TFA preparation)
Swiss-Prot :
P05067
Applications :
WB In vivo Assay In vitro Assay
Species :
Human
Protein Length :
42 amino acids
Amino Acid Sequence :
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGV
VIA
Purity :
>95%
Protein Size :
4.5 kDa
Conjugate :
No Tag
Cellular Localization :
Cell Membrane Intracellular Vesicles
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.