product summary
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company name :
StressMarq Biosciences
product type :
protein
product name :
Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (Baculovirus/Sf9)
catalog :
SPR-471
quantity :
100 µg
more info or order :
StressMarq Biosciences product webpage
citations: 4
Reference
Toral Rios D, Long J, ULRICH J, Yu J, Strickland M, Han X, et al. Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. J Exp Med. 2024;221: pubmed publisher
Adrian M, Weber M, Tsai M, Glock C, Kahn O, Phu L, et al. Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release. Nat Commun. 2023;14:6322 pubmed publisher
Wang C, Terrigno M, Li J, Distler T, Pandya N, Ebeling M, et al. Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation. Neuron. 2023;111:2660-2674.e9 pubmed publisher
Ungerleider K, Beck J, Lissa D, Turnquist C, Horikawa I, Harris B, et al. Astrocyte senescence and SASP in neurodegeneration: tau joins the loop. Cell Cycle. 2021;20:752-764 pubmed publisher
image
image 1 :
StressMarq Biosciences SPR-471 image 1
Thioflavin T assay of tau pre-formed fibrils (PFFs) combined with tau monomers. The PFFs seed the aggregation of the monomers
product information
Catalog No :
SPR-471
Product Name :
Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (Baculovirus/Sf9)
Description :
Human Recombinant Tau-441 (2N4R) P301S Mutant Protein Pre-formed Fibrils (Baculovirus/Sf9)
Size :
100 µg
Research Area(s) :
Alzheimer's Disease Axon Markers Cell Markers Cell Signaling Cytoskeleton Microtubules MT Associated Proteins Neurodegeneration Neuron Markers Neuroscience Tangles & Tau
Alternative Name(s) :
Tau PFFs, Tau PFF, Tau protein Pre-formed Fibrils, Tau aggregates, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, mouse Tau protein, P301S mutant Tau, 2N4R Tau, Tau441
Category :
Protein
Nature :
Recombinant
Accession Number :
NP_005901.2
Swiss-Prot :
P10636
Applications :
WB SDS-PAGE In vivo assay In vitro assay
Species :
Human
Expression System :
Baculovirus
Protein Length :
Full Length
Amino Acid Sequence :
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
Purity :
>95%
Protein Size :
~45.8 kDa
Conjugate :
No Tag
Cellular Localization :
Cytoplasm Axolemma Axolemma Plasma Membrane Axon Cell Body Cell membrane Cytoplasmic Ribonucleoprotein Granule Cytoplasmic Side Cytoskeleton Cytosol Dendrite Growth cone Microtubule Microtubule Associated Complex Neurofibrillary Tangle Neuronal Cell Body Nuclear Periphery Nuclear Speck Nucleus Peripheral membrane protein Plasma Membrane Tubulin Complex
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.