product summary
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company name :
StressMarq Biosciences
product type :
protein
product name :
Tau-441 (2N4R) P301S Mutant Monomers
catalog :
SPR-327
quantity :
100 µg
more info or order :
StressMarq Biosciences product webpage
citations: 2
Reference
Falkon K, Danford L, Gutierrez Kuri E, Esquinca Moreno P, Pe xf1 a Se xf1 eriz Y, Smith S, et al. Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms. Alzheimers Dement. 2025;21:e14418 pubmed publisher
Yang C, Luo Y, Guo K, Zheng C, Li L, Zhang L. Cornel Iridoid Glycoside Regulates Modification of Tau and Alleviates Synaptic Abnormalities in Aged P301S Mice. Curr Med Sci. 2020;40:1040-1046 pubmed publisher
image
image 1 :
StressMarq Biosciences SPR-327 image 1
SDS-PAGE of ~67 kDa Human Tau Protein 2N4R P301S Monomer (SPR-327). Lane 1: MW ladder. Lane 2: Tau Protein Monomer (SPR-327)
image 2 :
StressMarq Biosciences SPR-327 image 2
Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau monomers (SPR-327). A greater increase in fluorescence is seen when 50 uM monomer (SPR-327) is combined with 10 nM PFFs (SPR-329 or SPR-330), as the fibrils seed the formation of new fibrils from the pool of monomers. Thioflavin T ex = 450 nm, em = 485 nm. 10 uM heparin was added to each well.
image 3 :
StressMarq Biosciences SPR-327 image 3
Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau monomers (SPR-327). A greater increase in fluorescence is seen when 50 uM monomer (SPR-327) is combined with 10 nM PFFs (SPR-329 or SPR-330), as the fibrils seed the formation of new fibrils from the pool of monomers. Thioflavin T ex = 450 nm, em = 485 nm. 10 uM heparin was added to each well.
product information
Catalog No :
SPR-327
Product Name :
Tau-441 (2N4R) P301S Mutant Monomers
Description :
Human Recombinant Tau-441 (2N4R) P301S Mutant Protein Monomers
Size :
100 µg
Research Area(s) :
Alzheimer's Disease Axon Markers Cell Markers Cell Signaling Cytoskeleton Microtubules MT Associated Proteins Neurodegeneration Neuron Markers Neuroscience Tangles & Tau
Alternative Name(s) :
Tau monomer, Tau protein monomer, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Tau-441, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit
Category :
Protein
Nature :
Recombinant
Accession Number :
NP_005901.2
Swiss-Prot :
P10636
Applications :
WB SDS-PAGE In vivo assay In vitro assay
Species :
Human
Expression System :
E. coli
Protein Length :
Full Length
Amino Acid Sequence :
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
Purity :
>95%
Protein Size :
~45.8 kDa
Conjugate :
No tag
Cellular Localization :
Cytoplasm Axolemma Axolemma Plasma Membrane Axon Cell Body Cell membrane Cytoplasmic Ribonucleoprotein Granule Cytoplasmic Side Cytoskeleton Cytosol Dendrite Growth cone Microtubule Microtubule Associated Complex Neurofibrillary Tangle Neuronal Cell Body Nuclear Periphery Nuclear Speck Nucleus Peripheral membrane protein Plasma Membrane Tubulin Complex
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.