product summary
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company name :
StressMarq Biosciences
product type :
protein
product name :
Alpha Synuclein A53T Mutant Pre-formed Fibrils (Type 1)
catalog :
SPR-326
quantity :
100 µg
more info or order :
StressMarq Biosciences product webpage
citations: 2
Reference
Cho E, Kim K, Kim H, Cho S. Reelin protects against pathological α-synuclein accumulation and dopaminergic neurodegeneration after environmental enrichment in Parkinson's disease. Neurobiol Dis. 2022;175:105898 pubmed publisher
Cho E, Park J, Kim K, Kim M, Cho S. Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological α-Synuclein Expression in an In Vitro Model of Parkinson's Disease. Genes (Basel). 2021;12: pubmed publisher
image
image 1 :
StressMarq Biosciences SPR-326 image 1
Primary rat hippocampal neurons show lewy body inclusion formation when treated with A53T mutant Alpha Synuclein Protein Pre-formed Fibrils (SPR-326) (B) but not when treated with a media control (A). Tissue: Primary hippocampal neurons. Species: Sprague-Dawley rat. Primary Antibody: Rabbit anti-pSer129 Antibody. Fibrils were diluted to 1 ug/uL in neuronal media consisting of B27, Glutamax, penicillin/strip, and neurobasalA and sonicated for 1 hour in a water bath. The sonicated stock was then used to achieve the final concentration of 1 ug/mL in the wells.
image 2 :
StressMarq Biosciences SPR-326 image 2
TEM of A53T alpha synuclein Pre-formed Fibrils (SPR-326)
image 3 :
StressMarq Biosciences SPR-326 image 3
TEM of A53T alpha synuclein Pre-formed Fibrils (SPR-326)
product information
Catalog No :
SPR-326
Product Name :
Alpha Synuclein A53T Mutant Pre-formed Fibrils (Type 1)
Description :
Human Recombinant A53T Mutant Alpha Synuclein Protein Pre-formed Fibrils (Type 1)
Size :
100 µg
Research Area(s) :
Neuroscience Neurodegeneration Alzheimer's Disease Tangles & Tau Neuroscience Neurodegeneration Parkinson's Disease Synuclein Neuroscience Neurodegeneration Multiple System Atrophy
Alternative Name(s) :
A53T mutant alpha synuclein, A53T mutated SNCA, A53T Alpha synuclein PFFs, Alpha synuclein PFF, Ala53thr mutant alpha synuclein, Alpha synuclein pre-formed fibrils, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson disease familial 1 Protein
Category :
Protein
Nature :
Recombinant
Accession Number :
NP_000336.1
Swiss-Prot :
P37840
Applications :
WB SDS-PAGE In vivo assay In vitro assay
Species :
Human
Expression System :
E. coli
Protein Length :
Full Length
Amino Acid Sequence :
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Purity :
>95%
Protein Size :
~14.46 kDa
Conjugate :
No tag
Cellular Localization :
Cytoplasm Membrane Nucleus
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.