Alpha Synuclein Pre-formed Fibrils (Type 1) | StressMarq Biosciences SPR-324 product information

product summary

company name :

StressMarq Biosciences

product type :

protein

product name :

Alpha Synuclein Pre-formed Fibrils (Type 1)

catalog :

SPR-324

quantity :

100 µg

more info or order :

StressMarq Biosciences product webpage

citations: 16

Reference
Zheng Q, Gao Y, Han M, Wang Y, Liu H, Cao G, et al. Inhibiting Immune Crosstalk by Modulation of the Intracellular Function and Extracellular Environment of Diseased Microglia to Boost Parkinson's Disease Therapy. ACS Nano. 2025;19:19177-19197 pubmed publisher
Filippini A, Carini G, Barbon A, Gennarelli M, Russo I. Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils. Acta Neuropathol Commun. 2025;13:98 pubmed publisher
Desai A, Zupancic J, Trzeciakiewicz H, Gerson J, DuBois K, Skinner M, et al. Facile generation of drug-like conformational antibodies specific for amyloid fibrils. Nat Chem Biol. 2025;21:916-925 pubmed publisher
Maruf A, Gerasymchuk D, Hlushchuk I, Er S, Milewska M, Chmielarz P, et al. Trehalose-releasing nanogels reduce α-synuclein-induced Lewy body-like inclusions in primary mouse hippocampal neurons. J Mater Chem B. 2025;13:5845-5857 pubmed publisher
Trepczyk K, Er S, Hlushchuk I, Airavaara M, Alwani A, Maziarz K, et al. Peptidomimetics Activating the Proteasome: A New Perspective for Parkinson's Treatment. J Med Chem. 2025;68:8967-8979 pubmed publisher
Cao B, Chen X, Li Y, Zhou T, Chen N, Guo Y, et al. PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease. NPJ Parkinsons Dis. 2024;10:146 pubmed publisher
Parmasad J, Ricke K, Nguyen B, Stykel M, Buchner Duby B, Bruce A, et al. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Cell Death Dis. 2024;15:246 pubmed publisher
Desai A, Zupancic J, Trzeciakiewicz H, Gerson J, DuBois K, Skinner M, et al. Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils. bioRxiv. 2023;: pubmed publisher
Lee J, Sung K, Bae E, Yoon D, Kim D, Lee J, et al. Targeted degradation of ⍺-synuclein aggregates in Parkinson's disease using the AUTOTAC technology. Mol Neurodegener. 2023;18:41 pubmed publisher
Ghosh A, Verma D, Cabrera G, Ofori K, Hernandez Quijada K, Kim J, et al. A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models. Int J Mol Sci. 2022;23: pubmed publisher
Hlushchuk I, Barut J, Airavaara M, Luk K, Domanskyi A, Chmielarz P. Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules. 2022;12: pubmed publisher
Holland D, Prebble D, Er S, Hayton J, Robertson L, Avery V, et al. α-Synuclein Aggregation Inhibitory Prunolides and a Dibrominated β-Carboline Sulfamate from the Ascidian Synoicum prunum. J Nat Prod. 2022;85:441-452 pubmed publisher
Bhatia T, Clark R, Needham P, Miner K, Jamenis A, Eckhoff E, et al. Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy. Neurotherapeutics. 2021;: pubmed publisher
Verma D, Seo B, Ghosh A, Ma S, Hernandez Quijada K, Andersen J, et al. Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models. Cells. 2021;10: pubmed publisher
Hlushchuk I, Ruskoaho H, Domanskyi A, Airavaara M, Välimäki M. Domain-Independent Inhibition of CBP/p300 Attenuates α-Synuclein Aggregation. ACS Chem Neurosci. 2021;12:2273-2279 pubmed publisher
Verma D, Ghosh A, Ruggiero L, Cartier E, Janezic E, Williams D, et al. The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models. Eneuro. 2020;7: pubmed publisher

product information

Catalog No :

SPR-324

Product Name :

Alpha Synuclein Pre-formed Fibrils (Type 1)

Description :

Mouse Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

Size :

100 µg

Research Area(s) :

Neuroscience Neurodegeneration Alzheimer's Disease Tangles & Tau Neuroscience Neurodegeneration Parkinson's Disease Synuclein Neuroscience Neurodegeneration Multiple System Atrophy

Alternative Name(s) :

Alpha synuclein PFFs, Alpha synuclein PFF, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein

Category :

Protein

Nature :

Recombinant

Accession Number :

NP_001035916.1

Swiss-Prot :

O55042

Applications :

WB SDS-PAGE In vivo assay In vitro assay

Species :

Mouse

Expression System :

E. coli

Protein Length :

Full Length

Amino Acid Sequence :

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA

Purity :

>95%

Protein Size :

~14.46 kDa

Conjugate :

No tag

Cellular Localization :

Cytoplasm Membrane Nucleus

more info or order :

StressMarq Biosciences product webpage