Alpha Synuclein Pre-formed Fibrils (Type 1) | StressMarq Biosciences SPR-322 product information

product summary

company name :

StressMarq Biosciences

product type :

protein

product name :

Alpha Synuclein Pre-formed Fibrils (Type 1)

catalog :

SPR-322

quantity :

50 µg

more info or order :

StressMarq Biosciences product webpage

citations: 17

Reference
Zhylkibayev A, Starr C, Hossain M, Kumar S, Andrabi S, Grant M, et al. Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-Synucleinopathy. Cells. 2025;14: pubmed publisher
Schuler M, Gerwert G, Mann M, Woitzik N, Langenhoff L, Hubert D, et al. Alpha-synuclein misfolding as fluid biomarker for Parkinson's disease measured with the iRS platform. EMBO Mol Med. 2025;17:1203-1221 pubmed publisher
Suimon Y, Nishimura M, Murata M, Yoshida S, Yokoi K, Dong Z, et al. Leucine-Rich Repeat Kinase 2 Promotes Disintegration of Retinal Pigment Epithelial Cell: Implication in the Pathogenesis of Dry Age-Related Macular Degeneration. Am J Pathol. 2025;195:1294-1310 pubmed publisher
Clark K, White A, Paslawski W, Alexander K, Peng S, Young Pearse T, et al. Parkinson disease-associated toxic exposures selectively up-regulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons. Mol Biol Cell. 2025;36:br4 pubmed publisher
Frantzeskos S, Biggs M, Banerjee I. Exploring the Potential of Biomimetic Peptides in Targeting Fibrillar and Filamentous Alpha-Synuclein-An In Silico and Experimental Approach to Parkinson's Disease. Biomimetics (Basel). 2024;9: pubmed publisher
Fukumoto H, Kao T, Tai C, Jang M, Miyamoto M. High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005). FASEB J. 2024;38:e70160 pubmed publisher
Luo Y, Zang N, Tang Y, Chen H, Liu H, Wang L, et al. STAT3 Inhibitor Increases α-Synuclein in PFF-Treated Astroglia Cells by Dysregulating Autophagy and Potentially Affects Exosome Biogenesis. Neuromolecular Med. 2024;26:46 pubmed publisher
Luo H, Peng C, Wu C, Liu C, Li Q, Yu S, et al. Low-density lipoprotein receptor-related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's disease. Neural Regen Res. 2024;: pubmed publisher
Fern xe1 ndez Calvet A, Matilla Cuenca L, Izco M, Navarro S, Serrano M, Ventura S, et al. Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration. Nat Commun. 2024;15:4150 pubmed publisher
Parmasad J, Ricke K, Nguyen B, Stykel M, Buchner Duby B, Bruce A, et al. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Cell Death Dis. 2024;15:246 pubmed publisher
Horvath J, Casas M, Kutchukian C, S xe1 nchez S, Pergande M, Cologna S, et al. α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity. Cell Rep. 2023;42:113244 pubmed publisher
Nim S, O Hara D, Corbi Verge C, Perez Riba A, Fujisawa K, Kapadia M, et al. Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease. Nat Commun. 2023;14:2150 pubmed publisher
Jorge Oliva M, Smits J, Wiersma V, Hoozemans J, Scheper W. Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology. Alzheimers Res Ther. 2022;14:187 pubmed publisher
Gibbs E, Zhao B, Roman A, Plotkin S, Peng X, Hsueh S, et al. Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein. Biomedicines. 2022;10: pubmed publisher
Chen K, Martens Y, Meneses A, Ryu D, Lu W, Raulin A, et al. LRP1 is a neuronal receptor for α-synuclein uptake and spread. Mol Neurodegener. 2022;17:57 pubmed publisher
Cho E, Park J, Kim K, Kim M, Cho S. Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological α-Synuclein Expression in an In Vitro Model of Parkinson's Disease. Genes (Basel). 2021;12: pubmed publisher
Yakubu U, Morano K. Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones. J Biol Chem. 2021;296:100567 pubmed publisher

product information

Catalog No :

SPR-322

Product Name :

Alpha Synuclein Pre-formed Fibrils (Type 1)

Description :

Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

Size :

50 µg

Research Area(s) :

Neuroscience Neurodegeneration Alzheimer's Disease Tangles & Tau Neuroscience Neurodegeneration Parkinson's Disease Synuclein Neuroscience Neurodegeneration Multiple System Atrophy

Alternative Name(s) :

Alpha synuclein PFFs, Alpha synuclein aggregates, Alpha synuclein PFF, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein, Alpha synuclein protein seed

Category :

Protein

Nature :

Recombinant

Accession Number :

NP_000336.1

Swiss-Prot :

P37840

Applications :

WB SDS-PAGE In vivo assay In vitro assay

Species :

Human

Expression System :

E. coli

Protein Length :

Full Length

Amino Acid Sequence :

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Purity :

>95%

Protein Size :

~14.46 kDa

Conjugate :

No tag

Cellular Localization :

Cytoplasm Membrane Nucleus

more info or order :

StressMarq Biosciences product webpage