product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
UVRAG Antibody
catalog :
SPC-605D
quantity :
100 µg
price :
301.00 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
image
image 1 :
StressMarq Biosciences SPC-605D image 1
Western blot analysis of Rat Liver showing detection of ~70kDa UVRAG protein using Rabbit Anti-UVRAG Polyclonal Antibody (SPC-605). Lane 1: MW Ladder. Lane 2: Rat Liver (20 µg). Load: 20 µg. Block: 5% milk + TBST for 1 hour at RT. Primary Antibody: Rabbit Anti-UVRAG Polyclonal Antibody (SPC-605) at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit: HRP at 1:2000 for 1 hour at RT. Color Development: TMB solution for 12 min at RT. Predicted/Observed Size: ~70kDa.
product information
Catalog No :
SPC-605D
Product Name :
UVRAG Antibody
Description :
Rabbit Anti-Human UVRAG Polyclonal
Target :
UVRAG
Conjugate :
Unconjugated
2021 List Price :
301.00 USD
Currency :
USD
Research Area(s) :
Cancer Apoptosis Autophagy Cell Signaling Epigenetics and Nuclear Signaling Cardiovascular System Heart
Alternative Name(s) :
DHTX Antibody, p63 Antibody, UV radiation resistance associated Antibody, UVRAG_HUMAN Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Polyclonal
Immunogen :
Synthetic peptide from the C-terminal of human UVRAG
Immunogen Species :
Human
Accession Number :
NP_003360.2
Swiss-Prot :
Q9P2Y5
Applications :
WB ICC/IF
Host Species :
Rabbit
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Peptide Affinity Purified
Storage Buffer :
PBS, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SPC-605D, RRID: AB_2704799
Certificate of Analysis :
A 1:1000 dilution of SPC-605 was sufficient for detection of UVRAG on 293T Rapamycin treated lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
Cellular Localization :
Endosome Lysosome Endoplasmic reticulum Nucleus Chromosome Centromere
Scientific Background :
UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.
References :
1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 2. Ionov, Y. et al. (2004) Oncogene. 23: 639-45. 3. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SPC-605-UVRAG-Antibody-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SPC-605_UVRAG_Antibody_WB_Human_293T_1.png SPC-605_UVRAG_Antibody_WB_Rat_Liver_1.png
Image Alternative Text :
Rabbit Anti-UVRAG Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Neuroblastoma cell line (SK-N-BE) (SPC-605) Rabbit Anti-UVRAG Antibody used in Western blot (WB) on Embryonic kidney epithelial cell line (HEK293T) lysate (SPC-605) Rabbit Anti-UVRAG Antibody used in Western blot (WB) on Liver (SPC-605)
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.