Amyloid Fibrils (OC) Antibody | StressMarq Biosciences SPC-507D product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

Amyloid Fibrils (OC) Antibody

catalog :

SPC-507D

quantity :

100 µl

price :

289.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, dot blot

more info or order :

StressMarq Biosciences product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
dot blot; mouse; 1:1000; loading ...; fig 3b	Zha J, Liu X, Zhu J, Liu S, Lu S, Xu P, et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. Sci Rep. 2016;6:36631 pubmed publisher
	Nakajima H, Nishitsuji K, Kawashima H, Kuwabara K, Mikawa S, Uchimura K, et al. The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity. Amyloid. 2016;23:17-25 pubmed publisher

product information

Catalog No :

SPC-507D

Product Name :

Amyloid Fibrils (OC) Antibody

Description :

Rabbit Anti-Human Amyloid Fibrils (OC) Polyclonal

Target :

Amyloid

Conjugate :

Unconjugated

2021 List Price :

289.00 USD

Currency :

USD

Research Area(s) :

Neuroscience Cell Signaling Cardiovascular System Blood Neurodegeneration

Alternative Name(s) :

OC Antibody, Fibrils Antibody, Amyloid Oligomer aß Antibody, A11 Antibody, Amyloid beta A4 protein Antibody, ABPP Antibody, APPI Antibody, Alzheimer disease amyloid protein Antibody, Cerebral vascular amyloid peptide Antibody, PreA4 Antibody, Protease nexin-II Antibody, APP Antibody, A4 Antibody, AD Antibody

Size :

100 µl

Category :

Antibodies

Product Type :

Polyclonal

Immunogen :

Fibrils prepared from human amyloid beta 42 peptide

Immunogen Species :

Human

Applications :

WB IHC ICC/IF IP ELISA DB

Host Species :

Rabbit

Species Reactivity Abbreviation :

Species Reactivity Full Name :

Human

Antibody Dilution :

WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

Purification :

Protein A Purified

Storage Buffer :

PBS, 50% glycerol, 0.09% sodium azide

Specificity :

Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on species homology.

Storage Temperature :

-20ºC

Shipping Temperature :

Blue Ice or 4ºC

Cite this Product :

StressMarq Biosciences Cat# SPC-507D, RRID: AB_10960639

Certificate of Analysis :

A 1:1000 dilution of SPC-507 was sufficient for detection of amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Cellular Localization :

Membrane

Scientific Background :

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).

References :

1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

Field of Use :

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Image Filenames :

SPC-507_Amyloid_Antibody_WB_Human_AB42-fibrils-and-prefibrillar-oligomers_1.png SPC-507_Amyloid_Antibody_IHC_Human_Alzheimer's-Disease-brain_1.png SPC-507_Amyloid_Antibody_DB_Human_AB42-fibrils-and-prefibrillar-oligomers_1.png SPC-507_Amyloid_Antibody_DB_Human_Cell-lysates_1.png
SPC-507_Amyloid_Antibody_IHC_Human_Alzh
eimer's-Disease-brain_4Panel.png
SPC-507-Amyloid-Fibrils-OC-Antibody-IHC-Human-Alzheimer's-Disease-brain-1.png

Image Alternative Text :

Rabbit Anti-Amyloid Fibrils (OC) Antibody used in Immunohistochemistry (IHC) on Human Alzheimer's Disease brain (SPC-507) Rabbit Anti-Amyloid Fibrils (OC) Antibody used in Immunohistochemistry (IHC) on Human Alzheimer's Disease brain (SPC-507) Rabbit Anti-Amyloid Fibrils (OC) Antibody used in Western blot (WB) on Human Abeta42 fibrils and prefibrillar oligomers (SPC-507) Rabbit Anti-Amyloid Fibrils (OC) Antibody used in Immunohistochemistry (IHC) on Human Alzheimer's Disease brain (SPC-507) Rabbit Anti-Amyloid Fibrils (OC) Antibody used in Dot blot (DB) on Human Abeta42 fibrils and prefibrillar oligomers (SPC-507) Rabbit Anti-Amyloid Fibrils (OC) Antibody used in Dot blot (DB) on Human Cell lysates (SPC-507)

more info or order :

StressMarq Biosciences product webpage