Amyloid Oligomers (A11) Antibody | StressMarq Biosciences SPC-506D product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

Amyloid Oligomers (A11) Antibody

catalog :

SPC-506D

quantity :

100 µl

price :

289.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

StressMarq Biosciences product webpage

image

image 1 :

Dot blot analysis using Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody (SPC-506). Tissue: Abeta42 fibrils and prefibrillar oligomers. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody (SPC-506) at 1:1000. Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486–489. doi: 10.1126/science.1079469.

product information

Catalog No :

SPC-506D

Product Name :

Amyloid Oligomers (A11) Antibody

Description :

Rabbit Anti-Human Amyloid Oligomers (A11) Polyclonal

Target :

Amyloid

Conjugate :

Unconjugated

2021 List Price :

289.00 USD

Currency :

USD

Research Area(s) :

Neuroscience Cell Signaling Cardiovascular System Blood Neurodegeneration

Alternative Name(s) :

Amyloid Oligomer alpha beta Antibody, A11 Antibody, Amyloid Oligomer AlphaBeta Antibody, APP Antibody

Size :

100 µl

Category :

Antibodies

Product Type :

Polyclonal

Immunogen :

Synthetic molecular mimic of soluble oligomers

Immunogen Species :

Human

Accession Number :

NM_000484.2

Swiss-Prot :

P05067

Applications :

WB IHC ICC/IF IP ELISA

Host Species :

Rabbit

Species Reactivity Abbreviation :

Hu Ms Rt Eu

Species Reactivity Full Name :

Human Mouse Rat Eukaryote

Antibody Dilution :

The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100; optimal dilutions for assays should be determined by the user.

Purification :

Protein A Purified

Storage Buffer :

PBS, 50% glycerol, 0.09% sodium azide

Specificity :

Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Storage Temperature :

-20ºC

Shipping Temperature :

Blue Ice or 4ºC

Cite this Product :

StressMarq Biosciences Cat# SPC-506D, RRID: AB_10962958

Certificate of Analysis :

A 1:200 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 µg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Cellular Localization :

Membrane

Scientific Background :

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).

References :

1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

Field of Use :

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Image Filenames :

SPC-506-Amyloid-Oligomers-A11-Antibody-IHC-Human-Alzheimer's-Disease-brain-1.png SPC-506_Amyloid_Antibody_WB_Human_AB42-fibrils-and-prefibrillar-oligomers_1.png SPC-506_Amyloid_Antibody_DB_Human_AB42-fibrils-and-prefibrillar-oligomers_1.png

Image Alternative Text :

Rabbit Anti-Amyloid Oligomers (A11) Antibody used in Immunohistochemistry (IHC) on Human Alzheimer's Disease brain (SPC-506) Rabbit Anti-Amyloid Oligomers (A11) Antibody used in Western blot (WB) on Human Abeta42 fibrils and prefibrillar oligomers (SPC-506) Rabbit Anti-Amyloid Oligomers (A11) Antibody used in Dot blot (DB) on Human Abeta42 fibrils and prefibrillar oligomers (SPC-506)

more info or order :

StressMarq Biosciences product webpage