product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
ENaC gamma Antibody
catalog :
SPC-405
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
citations: 53
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 5c
Ferdaus M, Barber K, López Cayuqueo K, Terker A, Argaiz E, Gassaway B, et al. SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. J Physiol. 2016;594:4945-66 pubmed publisher
Vitzthum H, Koch M, Eckermann L, Svendsen S, Berg P, H xfc bner C, et al. The AE4 transporter mediates kidney acid-base sensing. Nat Commun. 2023;14:3051 pubmed publisher
Xu P, Sudarikova A, Ilatovskaya D, Gildea J, Akhter M, Carey R, et al. Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure. Biomedicines. 2022;10: pubmed publisher
Essigke D, Bohnert B, Janessa A, W xf6 rn M, Omage K, Kalbacher H, et al. Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity. Pflugers Arch. 2022;474:613-624 pubmed publisher
Hu C, Lakshmipathi J, Stuart D, Kohan D. Profiling renal sodium transporters in mice with nephron Ift88 disruption: Association with sex, cysts, and blood pressure. Physiol Rep. 2022;10:e15206 pubmed publisher
Tomilin V, Pyrshev K, Stavniichuk A, Hassanzadeh Khayyat N, Ren G, Zaika O, et al. Epac1-/- and Epac2-/- mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation. JCI Insight. 2022;7: pubmed publisher
Shi S, Buck T, Nickerson A, Brodsky J, Kleyman T. Paraoxonase 2 is an ER chaperone that regulates the epithelial Na+ channel. Am J Physiol Cell Physiol. 2022;322:C111-C121 pubmed publisher
Gumbel J, Yang C, Hubscher C. Timeline of Changes in Biomarkers Associated with Spinal Cord Injury-Induced Polyuria. Neurotrauma Rep. 2021;2:462-475 pubmed publisher
Hayakawa T, Fukuhara A, Saiki A, Otsuki M, Shimomura I. γENaC/CD9 in urinary extracellular vesicles as a potential biomarker of MR activity. J Endocrinol. 2021;252:81-90 pubmed publisher
Ray E, Pitzer A, Lam T, Jordahl A, Patel R, Ao M, et al. Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression. Am J Physiol Renal Physiol. 2021;321:F705-F714 pubmed publisher
Sassi A, Wang Y, Chassot A, Roth I, Ramakrishnan S, Olivier V, et al. Expression of claudin-8 is induced by aldosterone in renal collecting duct principal cells. Am J Physiol Renal Physiol. 2021;321:F645-F655 pubmed publisher
Lin M, Chen J, Tian X, Lee C, Yu I, Lo Y, et al. Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency. JCI Insight. 2021;6: pubmed publisher
Ochiai Homma F, Kuribayashi Okuma E, Tsurutani Y, Ishizawa K, Fujii W, Odajima K, et al. Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism. Hypertens Res. 2021;: pubmed publisher
Xiao Y, Duan X, Zhang D, Wang W, Lin D. Deletion of renal Nedd4-2 abolishes the effect of high K+ intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule. Am J Physiol Renal Physiol. 2021;321:F1-F11 pubmed publisher
Duan X, Wu P, Zhang D, Gao Z, Xiao Y, Ray E, et al. Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl- cotransporter. Am J Physiol Renal Physiol. 2021;320:F1045-F1058 pubmed publisher
Joshi H, Ram M, Limbu N, Rai D, Thapa B, LaBar K, et al. Modulation of optical absorption in m-Fe1-xRuxS2 and exploring stability in new m-RuS2. Sci Rep. 2021;11:6601 pubmed publisher
Wörner S, Bohnert B, Wörn M, Xiao M, Janessa A, Birkenfeld A, et al. Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice. Acta Pharmacol Sin. 2021;: pubmed publisher
Niu N, Yang X, Zhang B, Liang C, Zhu D, Wang Q, et al. Endothelial epithelial sodium channel involves in high-fat diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2021;1867:165989 pubmed publisher
Grant G, Coca C, Zhao X, Helms M. Oxidized Glutathione Increases Delta-Subunit Expressing Epithelial Sodium Channel Activity in Xenopus laevis Oocytes. Emed Res. 2020;2: pubmed
Song C, Yue Q, Moseley A, Al Khalili O, Wynne B, Ma H, et al. Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells. Am J Physiol Cell Physiol. 2020;319:C589-C604 pubmed publisher
Boyd Shiwarski C, Weaver C, Beacham R, Shiwarski D, Connolly K, Nkashama L, et al. Effects of extreme potassium stress on blood pressure and renal tubular sodium transport. Am J Physiol Renal Physiol. 2020;318:F1341-F1356 pubmed publisher
Wu P, Gao Z, Zhang D, Duan X, Terker A, Lin D, et al. Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice. J Am Heart Assoc. 2020;9:e014996 pubmed publisher
Wang M, Guo X, Zhao H, Lv J, Wang H, An Y. Adenosine A2B receptor activation stimulates alveolar fluid clearance through alveolar epithelial sodium channel via cAMP pathway in endotoxin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020;318:L787-L800 pubmed publisher
Walter C, Rafael C, Lasaad S, Baron S, Salhi A, Crambert G. H,K-ATPase type 2 regulates gestational extracellular compartment expansion and blood pressure in mice. Am J Physiol Regul Integr Comp Physiol. 2020;318:R320-R328 pubmed publisher
Dizin E, Olivier V, Maire C, Komarynets O, Sassi A, Roth I, et al. Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium. FASEB J. 2020;34:2408-2424 pubmed publisher
Lee H, Harris A, Romero M, Welling P, Wingo C, Verlander J, et al. NBCe1-A is required for the renal ammonia and K+ response to hypokalemia. Am J Physiol Renal Physiol. 2020;318:F402-F421 pubmed publisher
Wang F, Luo R, Peng K, Liu X, Xu C, Lu X, et al. Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells. Am J Physiol Renal Physiol. 2020;318:F817-F825 pubmed publisher
Lu X, Rudemiller N, Wen Y, Ren J, Hammer G, Griffiths R, et al. A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. Circ Res. 2019;125:1055-1066 pubmed publisher
Gumbel J, Montgomery L, Yang C, Hubscher C. Activity-Based Training Reverses Spinal Cord Injury-Induced Changes in Kidney Receptor Densities and Membrane Proteins. J Neurotrauma. 2019;: pubmed publisher
Hinrichs G, Weyer K, Friis U, Svenningsen P, Lund I, Nielsen R, et al. Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice. Acta Physiol (Oxf). 2019;227:e13362 pubmed publisher
Wu M, Liang C, Yu X, Song B, Yue Q, Zhai Y, et al. Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels. Br J Pharmacol. 2019;176:3695-3711 pubmed publisher
Zhai Y, Wu M, Linck V, Zou L, Yue Q, Wei S, et al. Intracellular cholesterol stimulates ENaC by interacting with phosphatidylinositol‑4,5‑bisphosphate and mediates cyclosporine A-induced hypertension. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1915-1924 pubmed publisher
Khedr S, Palygin O, Pavlov T, Blass G, Levchenko V, Alsheikh A, et al. Increased ENaC activity during kidney preservation in Wisconsin solution. BMC Nephrol. 2019;20:145 pubmed publisher
Blass G, Klemens C, Brands M, Palygin O, Staruschenko A. Postprandial Effects on ENaC-Mediated Sodium Absorption. Sci Rep. 2019;9:4296 pubmed publisher
Chen J, Lo Y, Lin Y, Lin S, Huang C, Cheng C. WNK4 kinase is a physiological intracellular chloride sensor. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Ilatovskaya D, Levchenko V, Pavlov T, Isaeva E, Klemens C, Johnson J, et al. Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). EBioMedicine. 2019;40:663-674 pubmed publisher
Garcia Caballero A, Gandini M, Huang S, Chen L, Souza I, Dang Y, et al. Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC. Mol Brain. 2019;12:12 pubmed publisher
Wu P, Gao Z, Su X, Wang M, Wang W, Lin D. Kir4.1/Kir5.1 Activity Is Essential for Dietary Sodium Intake-Induced Modulation of Na-Cl Cotransporter. J Am Soc Nephrol. 2019;30:216-227 pubmed publisher
Douma L, Solocinski K, Holzworth M, Crislip G, Masten S, Miller A, et al. Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension. Am J Physiol Regul Integr Comp Physiol. 2019;316:R50-R58 pubmed publisher
Fu Z, Hu J, Zhou L, Chen Y, Deng M, Liu X, et al. (Pro)renin receptor contributes to pregnancy-induced sodium-water retention in rats via activation of intrarenal RAAS and α-ENaC. Am J Physiol Renal Physiol. 2019;316:F530-F538 pubmed publisher
Gao Y, Stuart D, Takahishi T, Kohan D. Nephron-Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion. J Am Heart Assoc. 2018;7: pubmed publisher
Ramkumar N, Stuart D, Mironova E, Abraham N, Gao Y, Wang S, et al. Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion. Am J Physiol Renal Physiol. 2018;315:F607-F617 pubmed publisher
Liu M, Zhu Y, Sun Y, Wen Z, Huang S, Ding G, et al. MnTBAP therapy attenuates the downregulation of sodium transporters in obstructive kidney disease. Oncotarget. 2018;9:394-403 pubmed publisher
Zhang C, Wang L, Su X, Zhang J, Lin D, Wang W. ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice. Am J Physiol Renal Physiol. 2017;312:F682-F688 pubmed publisher
Xu N, Hirohama D, Ishizawa K, Chang W, Shimosawa T, Fujita T, et al. Hypokalemia and Pendrin Induction by Aldosterone. Hypertension. 2017;69:855-862 pubmed publisher
You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, et al. Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC. J Cell Sci. 2017;130:1027-1036 pubmed publisher
Klemens C, Edinger R, Kightlinger L, Liu X, Butterworth M. Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC). J Biol Chem. 2017;292:375-385 pubmed publisher
Pavlov T, Levchenko V, Ilatovskaya D, Moreno C, Staruschenko A. Renal sodium transport in renin-deficient Dahl salt-sensitive rats. J Renin Angiotensin Aldosterone Syst. 2016;17: pubmed publisher
Xu C, Lu A, Wang H, Fang H, Zhou L, Sun P, et al. (Pro)Renin receptor regulates potassium homeostasis through a local mechanism. Am J Physiol Renal Physiol. 2017;313:F641-F656 pubmed publisher
Reed Geaghan E, Wright M, See L, Adelman P, Lee K, Koerber H, et al. Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci. 2016;36:4362-76 pubmed publisher
Ramkumar N, Stuart D, Mironova E, Bugay V, Wang S, Abraham N, et al. Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport. Am J Physiol Renal Physiol. 2016;311:F186-94 pubmed publisher
Patel Chamberlin M, Varasteh Kia M, Xu J, Barone S, Zahedi K, Soleimani M. The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation. PLoS ONE. 2016;11:e0150918 pubmed publisher
Xu W, Huang Y, Li L, Sun Z, Shen Y, Xing J, et al. Hyperuricemia induces hypertension through activation of renal epithelial sodium channel (ENaC). Metabolism. 2016;65:73-83 pubmed publisher
image
image 1 :
StressMarq Biosciences SPC-405 image 1
Western blot analysis of Mouse kidney cortex showing detection of ENaC protein using Rabbit Anti-ENaC Polyclonal Antibody (SPC-405). Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-405) at 1:1000. Low-salt diet (lanes 1-4) compared to a high-salt diet (lanes 5-7). 70kDa degradation band observed in low-salt.
product information
Catalog No :
SPC-405
Product Name :
ENaC gamma Antibody
Description :
Rabbit Anti-Rat ENaC gamma Polyclonal
Target :
ENaC
Conjugate :
Unconjugated
Size 1 :
100 µg
PMIDs :
35743186 37236964 34755678 34605273 34852210 34632813 35312839 35625718 35274831 34914636 34901942 34499620 34326480 34029145 33900854 30559144 33758357 3375835831913688 33065235 32656545 32639874 32281415 32208832 32129084 32129084 31908015 31841392 31841393 31630621 31456470 31423748 31222723 31222723 31035971 30745171 30862903 30765526 30745171 30736831 30427705 30379098 31109455 31109455 29997131 297903902941662228289181 28137758 28137758 27895120 28365586 27443990 27440776 27076431 27068441 27053687 26963391 26892518 26418861 2620761225225551 25209858 25164814 25122048 24808538 24707975 23558339 23264685 23029554 22847418 21536685 21536685 24429824 24145067 22814399 22549242
Research Area(s) :
Neuroscience Neurotransmission Ion Channels Sodium Channels Epithelial Sodium Channels (ENaC)
Alternative Name(s) :
SCNN1G Antibody, Epithelial Sodium Channel gamma Antibody, Amiloride sensitive epithelial sodium channel gamma subunit Antibody, Amiloride sensitive sodium channel subunit gamma Antibody, Amiloride-sensitive sodium channel subunit gamma Antibody, BESC3 Antibody, ENaC gamma subunit Antibody, ENaCG Antibody, ENaCgamma Antibody, Epithelial Na(+) channel subunit gamma Antibody, Epithelial Na+ channel subunit gamma Antibody, Gamma ENaC Antibody, Gamma NaCH Antibody, Gamma-ENaC Antibody, Gamma-NaCH Antibody, Nonvoltage gated sodium channel 1 subunit gamma Antibody, Nonvoltage-gated sodium channel 1 subunit gamma Antibody, PHA 1 Antibody, PHA1 Antibody, SCNEG Antibody, SCNN 1G Antibody, SCNN1G Antibody, SCNNG_HUMAN Antibody, Sodium channel non voltage gated 1 gamma subunit Antibody, Sodium channel nonvoltage gated 1 gamma Antibody
Category :
Antibodies
Product Type :
Polyclonal
Immunogen :
Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
Immunogen Species :
Rat
Accession Number :
NP_058742
Swiss-Prot :
P37091
Applications :
WB IHC ICC/IF
Host Species :
Rabbit
Species Reactivity :
Rat Mouse Xenopus Hamster Human
Specificity :
Detects ~83kDa.
Image Filenames :
SPC-405_ENaC_Antibody_IHC_Rat_kidney-tissue_1.png SPC-405_ENaC_Antibody_WB_Rat_kidney-tissue-lysates_1.png SPC-405_ENaC_Antibody_WB_Mouse_kidney-cortex_1.png
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.