ENaC alpha Antibody | StressMarq Biosciences SPC-403 product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

ENaC alpha Antibody

catalog :

SPC-403

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

StressMarq Biosciences product webpage

citations: 47

Reference
Serirukchutarungsee S, Watari I, Narukawa M, Podyma Inoue K, Sangsuriyothai P, Ono T. Two-generation exposure to a high-fat diet induces the change of salty taste preference in rats. Sci Rep. 2023;13:5742 pubmed publisher
Li S, Pei H, Huang Y, Liu D, Yang L, Zhang Q, et al. Experimental study on the effect of chlorhexidine gluconate (CG)-induced atrial fibrillation on renal water and sodium metabolism. Sci Rep. 2023;13:4016 pubmed publisher
Xu P, Sudarikova A, Ilatovskaya D, Gildea J, Akhter M, Carey R, et al. Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure. Biomedicines. 2022;10: pubmed publisher
Hu C, Lakshmipathi J, Stuart D, Kohan D. Profiling renal sodium transporters in mice with nephron Ift88 disruption: Association with sex, cysts, and blood pressure. Physiol Rep. 2022;10:e15206 pubmed publisher
Sudarikova A, Fomin M, Sultanova R, Zhao Y, Perez S, Domondon M, et al. Functional role of histamine receptors in the renal cortical collecting duct cells. Am J Physiol Cell Physiol. 2022;322:C775-C786 pubmed publisher
Artunc F, Bohnert B, Schneider J, Staudner T, Sure F, Ilyaskin A, et al. Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice. Pflugers Arch. 2022;474:217-229 pubmed publisher
Gumbel J, Yang C, Hubscher C. Timeline of Changes in Biomarkers Associated with Spinal Cord Injury-Induced Polyuria. Neurotrauma Rep. 2021;2:462-475 pubmed publisher
Xiao Y, Duan X, Zhang D, Wang W, Lin D. Deletion of renal Nedd4-2 abolishes the effect of high K+ intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule. Am J Physiol Renal Physiol. 2021;321:F1-F11 pubmed publisher
Duan X, Wu P, Zhang D, Gao Z, Xiao Y, Ray E, et al. Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl- cotransporter. Am J Physiol Renal Physiol. 2021;320:F1045-F1058 pubmed publisher
Veiras L, Shen J, Bernstein E, Regis G, Cao D, Okwan Duodu D, et al. Renal Inflammation Induces Salt Sensitivity in Male db/db Mice through Dysregulation of ENaC. J Am Soc Nephrol. 2021;32:1131-1149 pubmed publisher
Ware A, Harris J, Slatter T, Cunliffe H, McDonald F. The epithelial sodium channel has a role in breast cancer cell proliferation. Breast Cancer Res Treat. 2021;187:31-43 pubmed publisher
Walter C, Rafael C, Genna A, Baron S, Crambert G. Increased colonic K+ excretion through inhibition of the H,K-ATPase type 2 helps reduce plasma K+ level in a murine model of nephronic reduction. Sci Rep. 2021;11:1833 pubmed publisher
Grant G, Coca C, Zhao X, Helms M. Oxidized Glutathione Increases Delta-Subunit Expressing Epithelial Sodium Channel Activity in Xenopus laevis Oocytes. Emed Res. 2020;2: pubmed
Song C, Yue Q, Moseley A, Al Khalili O, Wynne B, Ma H, et al. Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells. Am J Physiol Cell Physiol. 2020;319:C589-C604 pubmed publisher
Rein J, Heja S, Flores D, Carrisoza Gaytán R, Lin N, Homan K, et al. Effect of luminal flow on doming of mpkCCD cells in a 3D perfusable kidney cortical collecting duct model. Am J Physiol Cell Physiol. 2020;319:C136-C147 pubmed publisher
Wu P, Su X, Gao Z, Zhang D, Duan X, Xiao Y, et al. Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule. J Am Soc Nephrol. 2020;31:1226-1242 pubmed publisher
Wu P, Gao Z, Zhang D, Duan X, Terker A, Lin D, et al. Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice. J Am Heart Assoc. 2020;9:e014996 pubmed publisher
Wang M, Guo X, Zhao H, Lv J, Wang H, An Y. Adenosine A2B receptor activation stimulates alveolar fluid clearance through alveolar epithelial sodium channel via cAMP pathway in endotoxin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020;318:L787-L800 pubmed publisher
Lee H, Harris A, Romero M, Welling P, Wingo C, Verlander J, et al. NBCe1-A is required for the renal ammonia and K+ response to hypokalemia. Am J Physiol Renal Physiol. 2020;318:F402-F421 pubmed publisher
Wang F, Luo R, Peng K, Liu X, Xu C, Lu X, et al. Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells. Am J Physiol Renal Physiol. 2020;318:F817-F825 pubmed publisher
Manis A, Palygin O, Khedr S, Levchenko V, Hodges M, Staruschenko A. Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels. Clin Sci (Lond). 2019;133:2449-2461 pubmed publisher
Lu X, Rudemiller N, Wen Y, Ren J, Hammer G, Griffiths R, et al. A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. Circ Res. 2019;125:1055-1066 pubmed publisher
Gumbel J, Montgomery L, Yang C, Hubscher C. Activity-Based Training Reverses Spinal Cord Injury-Induced Changes in Kidney Receptor Densities and Membrane Proteins. J Neurotrauma. 2019;: pubmed publisher
Wu M, Liang C, Yu X, Song B, Yue Q, Zhai Y, et al. Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels. Br J Pharmacol. 2019;176:3695-3711 pubmed publisher
Khedr S, Palygin O, Pavlov T, Blass G, Levchenko V, Alsheikh A, et al. Increased ENaC activity during kidney preservation in Wisconsin solution. BMC Nephrol. 2019;20:145 pubmed publisher
Blass G, Klemens C, Brands M, Palygin O, Staruschenko A. Postprandial Effects on ENaC-Mediated Sodium Absorption. Sci Rep. 2019;9:4296 pubmed publisher
Chen J, Lo Y, Lin Y, Lin S, Huang C, Cheng C. WNK4 kinase is a physiological intracellular chloride sensor. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Ilatovskaya D, Levchenko V, Pavlov T, Isaeva E, Klemens C, Johnson J, et al. Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). EBioMedicine. 2019;40:663-674 pubmed publisher
Wu P, Gao Z, Su X, Wang M, Wang W, Lin D. Kir4.1/Kir5.1 Activity Is Essential for Dietary Sodium Intake-Induced Modulation of Na-Cl Cotransporter. J Am Soc Nephrol. 2019;30:216-227 pubmed publisher
Fu Z, Hu J, Zhou L, Chen Y, Deng M, Liu X, et al. (Pro)renin receptor contributes to pregnancy-induced sodium-water retention in rats via activation of intrarenal RAAS and α-ENaC. Am J Physiol Renal Physiol. 2019;316:F530-F538 pubmed publisher
Cherezova A, Tomilin V, Buncha V, Zaika O, Ortiz P, Mei F, et al. Urinary concentrating defect in mice lacking Epac1 or Epac2. FASEB J. 2019;33:2156-2170 pubmed publisher
Gao Y, Stuart D, Takahishi T, Kohan D. Nephron-Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion. J Am Heart Assoc. 2018;7: pubmed publisher
Ramkumar N, Stuart D, Mironova E, Abraham N, Gao Y, Wang S, et al. Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion. Am J Physiol Renal Physiol. 2018;315:F607-F617 pubmed publisher
Petrik D, Myoga M, Grade S, Gerkau N, Pusch M, Rose C, et al. Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner. Cell Stem Cell. 2018;22:865-878.e8 pubmed publisher
Yamauchi T, Doi S, Nakashima A, Doi T, Sohara E, Uchida S, et al. Na+-Cl- cotransporter-mediated chloride uptake contributes to hypertension and renal damage in aldosterone-infused rats. Am J Physiol Renal Physiol. 2018;315:F300-F312 pubmed publisher
Hashimoto H, Nomura N, Shoda W, Isobe K, Kikuchi H, Yamamoto K, et al. Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter. Metabolism. 2018;85:23-31 pubmed publisher
Liu M, Zhu Y, Sun Y, Wen Z, Huang S, Ding G, et al. MnTBAP therapy attenuates the downregulation of sodium transporters in obstructive kidney disease. Oncotarget. 2018;9:394-403 pubmed publisher
Zhang C, Wang L, Su X, Zhang J, Lin D, Wang W. ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice. Am J Physiol Renal Physiol. 2017;312:F682-F688 pubmed publisher
Mamenko M, Boukelmoune N, Tomilin V, Zaika O, Jensen V, O Neil R, et al. The renal TRPV4 channel is essential for adaptation to increased dietary potassium. Kidney Int. 2017;91:1398-1409 pubmed publisher
You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, et al. Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC. J Cell Sci. 2017;130:1027-1036 pubmed publisher
Klemens C, Edinger R, Kightlinger L, Liu X, Butterworth M. Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC). J Biol Chem. 2017;292:375-385 pubmed publisher
Zheng W, Li X, Liu H, Wang Z, Hu Q, Li Y, et al. AMP-Activated Protein Kinase Attenuates High Salt-Induced Activation of Epithelial Sodium Channels (ENaC) in Human Umbilical Vein Endothelial Cells. Oxid Med Cell Longev. 2016;2016:1531392 pubmed publisher
Pavlov T, Levchenko V, Ilatovskaya D, Moreno C, Staruschenko A. Renal sodium transport in renin-deficient Dahl salt-sensitive rats. J Renin Angiotensin Aldosterone Syst. 2016;17: pubmed publisher
Xu C, Lu A, Wang H, Fang H, Zhou L, Sun P, et al. (Pro)Renin receptor regulates potassium homeostasis through a local mechanism. Am J Physiol Renal Physiol. 2017;313:F641-F656 pubmed publisher
Ramkumar N, Stuart D, Mironova E, Bugay V, Wang S, Abraham N, et al. Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport. Am J Physiol Renal Physiol. 2016;311:F186-94 pubmed publisher
Patel Chamberlin M, Varasteh Kia M, Xu J, Barone S, Zahedi K, Soleimani M. The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation. PLoS ONE. 2016;11:e0150918 pubmed publisher
Ramkumar N, Stuart D, Calquin M, Wang S, Niimura F, Matsusaka T, et al. Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension. Physiol Rep. 2016;4: pubmed publisher

image

image 1 :

Immunohistochemistry analysis using Rabbit Anti-ENaC Polyclonal Antibody (SPC-403). Tissue: kidney tissue. Species: Rat. Fixation: Formalin Fixed Paraffin-Embedded. Primary Antibody: Rabbit Anti-ENaC Polyclonal Antibody (SPC-403) at 1:25 for 1 hour at RT. Secondary Antibody: Goat Anti-Rabbit IgG: Alexa Fluor 488. Counterstain: Actin-binding Phalloidin-Alexa Fluor 633; DAPI (blue) nuclear stain. Magnification: 63X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Alex Fluor 633 F-Actin stain. (C)ENaC Antibody (D) Composite

product information

Catalog No :

SPC-403

Product Name :

ENaC alpha Antibody

Description :

Rabbit Anti-Rat ENaC alpha Polyclonal

Target :

ENaC

Conjugate :

Unconjugated

Size 1 :

100 µg

PMIDs :

35081320 35081320 36899056 37029190 35625718 35274831 34870751 34901942 34029145 33900854 30559144 33731332 33731332 33630195 3346905132656545 32639874 32401606 32295826 32208832 32129084 32129084 31841392 31841393 31799617 31630621 31456470 31222723 3122272331035971 30862903 30765526 30745171 30379098 30252533 28187982 29997131 29790390 29779889 29631358 29510178 29416622 28137758 28137758 28137758 28137758 27895120 28365586 27443990 27440776 27635187 27053687 26963391 26755736 26418861 26207612 26207612 2594134025164814 25122048 24958889 24808538 24707975 23558339 23264685 23171554 26069797 23029554 24145067 24060890 24060890 22814399 22549242

Research Area(s) :

Neuroscience Neurotransmission Ion Channels Sodium Channels Epithelial Sodium Channels (ENaC)

Alternative Name(s) :

SCNN1A Antibody, Epithelial Sodium Channel-α Antibody, Epithelial Sodium Channel alpha Antibody, Alpha ENaC 2 Antibody, Alpha ENaC Antibody, Alpha NaCH Antibody, Alpha-ENaC Antibody, Amiloride sensitive epithelial sodium channel alpha subunit Antibody, Amiloride sensitive sodium channel subunit alpha Antibody, Amiloride-sensitive sodium channel subunit alpha Antibody, ENaCa Antibody, ENaCalpha Antibody, Epithelial Na(+) channel subunit alpha Antibody, Epithelial Na+ channel subunit alpha Antibody, FLJ21883 Antibody, Nonvoltage gated sodium channel 1 subunit alpha Antibody, Nonvoltage-gated sodium channel 1 subunit alpha Antibody, SCNEA Antibody, SCNN 1 Antibody, SCNN1 Antibody, SCNN1A Antibody, SCNNA_HUMAN Antibody, Sodium channel nonvoltage gated 1 alpha Antibody

Category :

Antibodies

Product Type :

Polyclonal

Immunogen :

Produced against a synthetic peptide mapping to the N-terminal of the alpha subunit (amino acids 46-68) of rat Alpha ENaC (antibody designation 3560-2).

Immunogen Species :

Rat

Accession Number :

NP_113736

Swiss-Prot :

Q6IRJ1

Applications :

WB IHC ICC/IF IP

Host Species :

Rabbit

Species Reactivity :

Human Rat Mouse Xenopus

Specificity :

Detects ~85kDa.

Image Filenames :

SPC-403_ENaC_Antibody_IHC_Rat_kidney-tissue_63X_1.png SPC-403_ENaC_Antibody_WB_Rat_kidney-tissue-lysates_1.png SPC-403_ENaC_Antibody_WB_Mouse_kidney-tissue-lysates_1.png

more info or order :

StressMarq Biosciences product webpage