Calcineurin A Antibody | StressMarq Biosciences SPC-175D product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

Calcineurin A Antibody

catalog :

SPC-175D

quantity :

100 µg

price :

278.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

StressMarq Biosciences product webpage

product information

Catalog No :

SPC-175D

Product Name :

Calcineurin A Antibody

Description :

Rabbit Anti-Human Calcineurin A Polyclonal

Target :

Calcineurin A

Conjugate :

Unconjugated

2021 List Price :

278.00 USD

Currency :

USD

Research Area(s) :

Cell Signaling Post-translational Modifications Phosphorylation

Alternative Name(s) :

Alpha isoform formerly PPP2B Antibody, Calcineurin A alpha Antibody, Calcineurin A1 Antibody, CalcineurinA Antibody, Calmodulin dependent calcineurin A subunit alpha isoform Antibody, Calmodulin-dependent calcineurin A subunit alpha isoform Antibody, CALN Antibody, CALNA Antibody, CALNA 1 Antibody, CAM PRP catalytic subunit Antibody, CCN 1 Antibody, Protein phosphatase 2B catalytic subunitProtein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform Antibody, Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA Antibody, Protein phosphatase 3 catalytic subunit alpha isozyme Antibody, Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform Antibody

Size :

100 µg

Category :

Antibodies

Product Type :

Polyclonal

Immunogen :

Human Calcineurin A peptide (AA 264-283)

Immunogen Species :

Human

Accession Number :

Q08209

Swiss-Prot :

Q08209

Applications :

WB IHC ICC/IF IP

Host Species :

Rabbit

Species Reactivity Abbreviation :

Hu Ms Rt Dg Rb

Species Reactivity Full Name :

Human Mouse Rat Dog Rabbit

Antibody Dilution :

WB (1:1000), ICC/IF (1:120), IHC (1:100); optimal dilutions for assays should be determined by the user.

Purification :

Peptide Affinity Purified

Storage Buffer :

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Concentration :

1 mg/ml

Specificity :

Detects ~61kDa.

Storage Temperature :

-20ºC

Shipping Temperature :

Blue Ice or 4ºC

Cite this Product :

StressMarq Biosciences Cat# SPC-175D, RRID: AB_2703856

Certificate of Analysis :

1 µg/ml of SPC-175 was sufficient for detection of Calcineurin A in 20 µg of Heat shock Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Cellular Localization :

Nucleus

Scientific Background :

Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit(1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs(2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 (3).

References :

1. Rusnak F. and Mertz P. (2000) Physiol Rev. 80(4):1483-521. 2. Hemenway C.S. And Heitman J. (1999)Cell Biochem Biophys. 30(1):115-51. 3. Fox D.S. and Heitman J. (2002) Bioessays. 24(10):894-903.

Field of Use :

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Image Filenames :

SPC-175_Calcineurin-A_Antibody_ICC-IF_Human_HeLa-Cells_100x_Composite.png SPC-175_Calcineurin-A_Antibody_IHC_Mouse_backskin_1.png SPC-175_Calcineurin-A_Antibody_WB_Rat_Brain-cell-lysates_1.png SPC-175_Calcineurin-A_Antibody_ICC-IF_Human_HeLa-Cells_20x_Composite.png

Image Alternative Text :

Rabbit Anti-Calcineurin A Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Cervical cancer cell line (HeLa) (SPC-175) Rabbit Anti-Calcineurin A Antibody used in Immunohistochemistry (IHC) on Mouse backskin (SPC-175) Rabbit Anti-Calcineurin A Antibody used in Western blot (WB) on Brain cell lysates (SPC-175) Rabbit Anti-Calcineurin A Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Cervical cancer cell line (HeLa) (SPC-175)

more info or order :

StressMarq Biosciences product webpage