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company name :
StressMarq Biosciences
product type :
antibody
product name :
TNF-R1 Antibody
catalog :
SPC-170D
quantity :
100 µg
price :
283.00 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SPC-170D
Product Name :
TNF-R1 Antibody
Description :
Rabbit Anti-Mouse TNF-R1 Polyclonal
Target :
TNFR1
Conjugate :
Unconjugated
2021 List Price :
283.00 USD
Currency :
USD
Research Area(s) :
Cancer Apoptosis Cell Signaling Cardiovascular System Atherosclerosis
Alternative Name(s) :
Tumor necrosis factor receptor 1 Antibody, TNFR-1 Antibody, TNFRSF1A Antibody, TNFAR Antibody, TNFR1 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Polyclonal
Immunogen :
Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
Immunogen Species :
Mouse
Accession Number :
P19438
Swiss-Prot :
P19438
Applications :
WB IHC ICC/IF IP
Host Species :
Rabbit
Species Reactivity Abbreviation :
Hu Ms Rt Bv Mk Dg Rb
Species Reactivity Full Name :
Human Mouse Rat Bovine Monkey Dog Rabbit
Antibody Dilution :
WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Peptide Affinity Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~55kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SPC-170D, RRID: AB_2703803
Certificate of Analysis :
1 µg/ml of SPC-170 was sufficient for detection of TNFR1 in 20 µg of Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Cellular Localization :
Cell Membrane Golgi Apparatus Golgi Apparatus Membrane
Scientific Background :
The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
References :
1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34. 2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20. 3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SPC-170_TNF-R1_Antibody_ICC-IF_Human_HeLa-Cells_100x_Composite.png SPC-170_TNF-R1_Antibody_IHC_Mouse_backskin_1.png SPC-170_TNF-R1_Antibody_WB_Mouse_Liver-cell-lysates_1.png SPC-170_TNF-R1_Antibody_ICC-IF_Human_HaCaT-cells_1.png SPC-170_TNF-R1_Antibody_ICC-IF_Human_HeLa-Cells_20x_Composite.png
Image Alternative Text :
Rabbit Anti-TNF-R1 Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Cervical cancer cell line (HeLa) (SPC-170) Rabbit Anti-TNF-R1 Antibody used in Immunohistochemistry (IHC) on Mouse backskin (SPC-170) Rabbit Anti-TNF-R1 Antibody used in Western blot (WB) on Liver cell lysates (SPC-170) Rabbit Anti-TNF-R1 Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human HaCaT cells (SPC-170) Rabbit Anti-TNF-R1 Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Cervical cancer cell line (HeLa) (SPC-170)
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.