CDC37 Antibody | StressMarq Biosciences SPC-142D product information

product summary

company name :

StressMarq Biosciences

product type :

antibody

product name :

CDC37 Antibody

catalog :

SPC-142D

quantity :

100 µg

price :

234.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry

more info or order :

StressMarq Biosciences product webpage

image

image 1 :

Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-CDC37 Polyclonal Antibody (SPC-142). Tissue: Heat Shocked Cervical cancer cell line (HeLa). Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody (SPC-142) at 1:200 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 20x. (A) DAPI (blue) nuclear stain. (B) Anti-CDC37 Antibody. (C) Composite. Heat Shocked at 42°C for 30 min.

product information

Catalog No :

SPC-142D

Product Name :

CDC37 Antibody

Description :

Rabbit Anti-Human CDC37 Polyclonal

Target :

CDC37

Conjugate :

Unconjugated

2021 List Price :

234.00 USD

Currency :

USD

Research Area(s) :

Cancer Heat Shock Cell Signaling Epigenetics and Nuclear Signaling

Alternative Name(s) :

Hsp90 co chaperone Cdc37 antibody, CDC 37 antibody, Cdc37 antibody, CDC37 cell division cycle 37 homolog antibody, CDC37 cell division cycle 37 S cerevisiae homolog antibody, CDC37 cell division cycle 37 S cerevisiae homolog of antibody, Cdc37 homolog antibody, CDC37 protein antibody, CDC37_HUMAN antibody, CDC37A antibody, cell division cycle 37 antibody, Cell division cycle 37 homolog antibody, Hsp90 chaperone protein kinase targeting subunit antibody, Hsp90 chaperone protein kinase targeting subunit p50Cdc37 antibody, Hsp90 chaperone protein kinase-targeting subunit antibody, Hsp90 co-chaperone Cdc37 antibody, p50 antibody, p50Cdc37 antibody, S cerevisiae hypothetical protein CDC37 antibody

Size :

100 µg

Category :

Antibodies

Product Type :

Polyclonal

Immunogen :

Native human Cdc37, full length

Immunogen Species :

Human

Accession Number :

NP_008996.1

Swiss-Prot :

Q16543

Applications :

WB ICC/IF

Host Species :

Rabbit

Species Reactivity Abbreviation :

Species Reactivity Full Name :

Human

Antibody Dilution :

WB (1:2000), ICC/IF (1:200); optimal dilutions for assays should be determined by the user.

Purification :

Protein A Purified

Storage Buffer :

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Concentration :

1.68 mg/ml

Specificity :

Detects ~44.5kDa.

Storage Temperature :

-20ºC

Shipping Temperature :

Blue Ice or 4ºC

Cite this Product :

StressMarq Biosciences Cat# SPC-142D, RRID: AB_11232608

Certificate of Analysis :

A 1:2000 dilution of SPC-142 was sufficient for detection of cdc37 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.

Cellular Localization :

Cytoplasm

Scientific Background :

HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).

References :

1. Dai K, Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034. 2. Stepanova L, Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502. 3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775-1185. 4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491-495.

Field of Use :

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Image Filenames :

SPC-142_CDC37_Antibody_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png SPC-142_CDC37_Antibody_WB_Human_HeLa-cell-lysates_1.png SPC-142_CDC37_Antibody_ICC-IF_Human_Heat-Shocked-HeLa-Cells_20x_Composite.png

Image Alternative Text :

Rabbit Anti-CDC37 Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Heat Shocked Cervical cancer cell line (HeLa) (SPC-142) Rabbit Anti-CDC37 Antibody used in Western blot (WB) on Human Cervical cancer cell line (HeLa) lysate (SPC-142) Rabbit Anti-CDC37 Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Heat Shocked Cervical cancer cell line (HeLa) (SPC-142)

more info or order :

StressMarq Biosciences product webpage