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company name :
StressMarq Biosciences
product type :
antibody
product name :
NPAS4 Antibody
catalog :
SMC-495D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S408-79
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-495D
Product Name :
NPAS4 Antibody
Description :
Mouse Anti-Rat NPAS4 Monoclonal IgG1
Target :
NPAS4
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Cell Signaling Epigenetics and Nuclear Signaling Neuroscience
Alternative Name(s) :
Neuronal PAS domain-containing protein 4 Antibody, Neuronal PAS4 Antibody, Class E basic helix-loop-helix protein 79 Antibody, HLH-PAS transcription factor NXF Antibody, PAS domain-containing protein 10 Antibody, Limbic-enhanced PAS protein Antibody, bHLHe79 Antibody, PASD10 Antibody and LE-PAS Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S408-79
Immunogen :
Fusion protein amino acids 597-802 (C-terminus) of rat Npas4.
Immunogen Species :
Rat
Accession Number :
NP_705890.1
Swiss-Prot :
Q8CJH6
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG1
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), ICC/IF(1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~90kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-495D, RRID: AB_2702621
Certificate of Analysis :
A 1:100 dilution of SMC-495 was sufficient for detection of NPAS4 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Cytoplasm Nucleus
Tissue Specificity :
Highly expressed in the brain, with lower expression found in endocrine tissue.
Scientific Background :
NPAS4 belongs to the Per-Arnt-Sim family of neuronal specific transciption factors, all involved in the development and maintenance of learning and memory pathways (1). NPAS4 is a transcription factor that regulates the formation and maintenance of inhibitory synapses, and can activate the CNS midline enhancer element and the expression of the drebrin gene. Deregulation has been to be associated with developmental disorders such as schizophrenia and autism (2).
References :
1. Zhaohui Z., et al. (2014) Exp Ther Med. 7(4): 1045-1049. 2. Coutellier L., et al. (2012) Plos One. 7(9): e46604.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-495_NPAS4_Antibody_S408-79_ICC-IF_Human_Neuroblastoma-cell-line-SK-N-BE_60X_Composite_1.png SMC-495_NPAS4_Antibody_S408-79_WB_Rat_Brain__1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.