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company name :
StressMarq Biosciences
product type :
antibody
product name :
Ankyrin R Antibody
catalog :
SMC-487D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S388A-10
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-487D
Product Name :
Ankyrin R Antibody
Description :
Mouse Anti-Human Ankyrin R Monoclonal IgG2B
Target :
Ankyrin R
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Cell Markers Neuron Markers Membrane Markers Cell Signaling Scaffold Proteins Cardiovascular System Blood
Alternative Name(s) :
Ankyrin-R Antibody, Ankyrin-1 Antibody, Erythrocyte Ankyrin Antibody, ANK-1 Antibody, ANK Antibody, rCG_43073 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S388A-10
Immunogen :
Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
Immunogen Species :
Human
Accession Number :
NP_000028.3
Swiss-Prot :
P16157
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG2B
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~200kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-487D, RRID: AB_2702477
Certificate of Analysis :
A 1:100 dilution of SMC-487 was sufficient for detection of Ankyrin R in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Cytoplasm Cytoskeleton Myofibril Sarcomere M line
Scientific Background :
Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).
References :
1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92. 2. Genes and mapped phenotypes. (n.d.). Retrieved April 21, 2015, from http://www.ncbi.nlm.nih.gov/gene/286
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-487-Ankyrin-R-Antibody-S388A-10-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-487_Ankyrin-R_Antibody_S388A-10_WB_Rat_Brain__1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.