product summary
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company name :
StressMarq Biosciences
product type :
antibody
product name :
Nav beta2 Antibody
catalog :
SMC-485D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S395-68
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
product information
Catalog No :
SMC-485D
Product Name :
Nav beta2 Antibody
Description :
Mouse Anti-Mouse Nav beta2 Monoclonal IgG2B
Target :
Nav beta2
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Ion Channels Sodium Channels Voltage-Gated Sodium Channels
Alternative Name(s) :
Sodium channel subunit beta-2 Antibody, Scn2b Antibody, UNQ326/PRO386 Antibody, Gm183 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S395-68
Immunogen :
Fusion protein amino acids 1-215 (full-length) of mouse Nav beta2
Immunogen Species :
Mouse
Accession Number :
NP_001014761.1
Swiss-Prot :
Q56A07
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG2B
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~40kDa. Does not cross-reat with NavBeta1, Navbeta3, or Navbeta4.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-485D, RRID: AB_2702441
Certificate of Analysis :
A 1:100 dilution of SMC-485 was sufficient for detection of Nav beta2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Membrane
Scientific Background :
NavBeta2 or Scn2B, plays a crucial role in the assembly, expression and functional modulation of the heterotrimeric complex of the sodium channel. The subunit, beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. It also interacts with TNR, playing a crucial role in clustering and regulation of activity of sodium channels at the nodes of Ranvier (1, 2). Mutations in this gene have been linked to Brugada syndrome and atrial fibrillation (3).
References :
1. Genes and mapped phenotypes. (n.d.). Retrieved March 16, 2015, from http://www.ncbi.nlm.nih.gov/gene/6327
2. Eubanks J., Srinivasan J., Dinulos M.B., Disteche C.M., Catterall W.A. (1997) Neuroreport. 8(12): 2775-2779.
3. Riuro H., et al. (2013) Hum Mutat. 34(7): 961-966.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-485-Nav-beta-2-Antibody-S395-68-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-485_Nav-Beta-2_Antibody_S395-68_WB_Rat_Brain__1.png
more info or order :
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.