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company name :
StressMarq Biosciences
product type :
antibody
product name :
Trak2 Antibody
catalog :
SMC-483D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S390-43
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-483D
Product Name :
Trak2 Antibody
Description :
Mouse Anti-Human Trak2 Monoclonal IgG2A
Target :
TRAK2
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Neurodegeneration Alzheimer's Disease
Alternative Name(s) :
Trafficking kinesin-binding protein 2 Antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein Antibody, GABA-A receptor-interacting factor 1 Antibody, O-GlcNAc transferase-interacting protein of 98 kDa Antibody, EMBL AAH60681.1 Antibody, Ensembl ENSMUSP00000027186 MGI 1918077 Antibody, Als2cr3 Antibody, Grif1 Antibody, Oip98 Antibody, KIAA0549 Antibody, TRAK2_Human Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S390-43
Immunogen :
Fusion protein amino acids 757-914 (C-terminus) of human TRAK2
Immunogen Species :
Human
Accession Number :
NP_055864.2
Swiss-Prot :
O60296
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG2A
Species Reactivity Abbreviation :
Hu Rt
Species Reactivity Full Name :
Human Rat
Antibody Dilution :
WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~100kDa. Does not cross-react with TRAK1.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-483D, RRID: AB_2702405
Certificate of Analysis :
A 1:100 dilution of SMC-483 was sufficient for detection of Trak2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Cytoplasm Mitochondrion Early Endosome
Scientific Background :
TRAK2, a member of the TRAK family of adaptor proteins, links mitochondria to microtubule based motors. Localized in dendrites, it is specifically required for dendritic development as it reacts with dynein and dynactin. TRAK2 interferes with kinesin-1 binding and axonal transport (1). It has been shown to interact with Kir2.1 and GABA-R Beta2 (2, 3).
References :
1. van Spronsen M. et al. (2013) Neuron. 77(3): 48-502. 2. Grishin A., Li H., Levitan E.S., Zaks E. (2006) J Biol Chem. 281(4): 30104-30111. 3. Beck M., et al. (2002) J Biol Chem. 277(33): 30079-30090.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-483-Trak2-Antibody-S390-43-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-483_TRAK2_Antibody_S390-43_WB_Rat_Brain-Membrane__1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.