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company name :
StressMarq Biosciences
product type :
antibody
product name :
REEP1 Antibody
catalog :
SMC-480D
quantity :
100 µg
price :
300.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S345-51
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
StressMarq Biosciences product webpage
product information
Catalog No :
SMC-480D
Product Name :
REEP1 Antibody
Description :
Mouse Anti-Mouse REEP1 Monoclonal IgG2B
Target :
REEP1
Conjugate :
Unconjugated
2021 List Price :
300.00 USD
Currency :
USD
Research Area(s) :
Neuroscience Neurodegeneration Spastic Paraplegia Cell Markers Neuron Markers Membrane Markers
Alternative Name(s) :
Receptor expression-enhancing protein 1 Antibody, C2orf23 Antibody, D6Ertd253e Antibody, rcG_56072 Antibody, Reep1 Antibody, SPG31 Antibody
Size :
100 µg
Category :
Antibodies
Product Type :
Monoclonal
Clone Number :
S345-51
Immunogen :
Fusion protein amino acids 111-201 of mouse REEP1
Immunogen Species :
Mouse
Accession Number :
NP_848723.1
Swiss-Prot :
Q8BGH4
Applications :
WB IHC ICC/IF
Host Species :
Mouse
Isotype :
IgG2B
Species Reactivity Abbreviation :
Hu Ms Rt
Species Reactivity Full Name :
Human Mouse Rat
Antibody Dilution :
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification :
Protein G Purified
Storage Buffer :
PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration :
1 mg/ml
Specificity :
Detects ~22kDa.
Storage Temperature :
-20ºC
Shipping Temperature :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-480D, RRID: AB_2702351
Certificate of Analysis :
A 1:100 dilution of SMC-480 was sufficient for detection of REEP1 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Mitochondrion Mitochondrion Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane
Scientific Background :
REEP1 (receptor expression-enhancing protein 1), is a 201 amino acid multi-pass mitochondrion membrane protein that belongs to the DP1 family. REEP1 interacts with odorant receptor proteins and may enhance the cell surface expression of odorant receptors (1, 2). It is also required for endoplasmic-reticulum network formation shaping and remodeling by linking ER tubules to the cytoskeleton (2). Mutations in the REEP1 gene are a common cause of hereditary spastic paraplegia (HSP). Mutations in the REEP1 gene also cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder (3).
References :
1. Genes and mapped phenotypes. (n.d.). Retrieved March 11, 2015, from http://www.ncbi.nlm.nih.gov/gene/65055 2. Park S.H., Zhu P.P., Parker R.L. Blackstone C. (2010) J Clin Invest. 120(4): 1097-1110. 3. REEP1 - Receptor expression-enhancing protein 1 - Homo sapiens (Human). (n.d.). Retrieved March 11, 2015, from http://www.uniprot.org/uniprot/Q9H902
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-480-REEP1-Antibody-S345-51-ICC-IF-Human-Neuroblastoma-cell-line-SK-N-BE-60X-Composite-1.png SMC-480_REEP1_Antibody_S345-51_WB_Rat_Brain__1.png
more info or order :
StressMarq Biosciences product webpage
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.